Search Results - "Holthof, Lisa"

Challenges for Immunotherapy in Multiple Myeloma: Bone Marrow Microenvironment-Mediated Immune Suppression and Immune Resistance by Holthof, Lisa C, Mutis, Tuna

“…The power of immunotherapy in the battle of Multiple Myeloma (MM) started with allogeneic stem cell transplantation, and was rediscovered with immunomodulatory…”
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STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes by Andersen, Morten Nørgaard, Etzerodt, Anders, Graversen, Jonas H., Holthof, Lisa C., Moestrup, Søren K., Hokland, Marianne, Møller, Holger J.

“…Tumor-associated macrophages (TAMs) are of major importance in cancer-related immune suppression, and tumor infiltration by CD163 pos TAMs is associated with…”
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Preclinical Activity of JNJ-7957, a Novel BCMA×CD3 Bispecific Antibody for the Treatment of Multiple Myeloma, Is Potentiated by Daratumumab by Frerichs, Kristine A, Broekmans, Marloes E C, Marin Soto, Jhon A, van Kessel, Berris, Heymans, Martijn W, Holthof, Lisa C, Verkleij, Christie P M, Boominathan, Rengasamy, Vaidya, Bhavesh, Sendecki, Jocelyn, Axel, Amy, Gaudet, Francois, Pillarisetti, Kodandaram, Zweegman, Sonja, Adams, 3rd, Homer C, Mutis, Tuna, van de Donk, Niels W C J

“…Multiple myeloma (MM) patients with disease refractory to all available drugs have a poor outcome, indicating the need for new agents with novel mechanisms of…”
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Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis by Holthof, Lisa C, van der Schans, Jort J, Katsarou, Afroditi, Poels, Renée, Gelderloos, Anne T, Drent, Esther, van Hal-van Veen, Susan E, Li, Fengzhi, Zweegman, Sonja, van de Donk, Niels W C J, Themeli, Maria, Groen, Richard W J, Mutis, Tuna

“…The microenvironment of multiple myeloma (MM) can critically impair therapy outcome, including immunotherapies. In this context, we have earlier demonstrated…”
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Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma by Holthof, Lisa C, van der Horst, Hilma J, van Hal-van Veen, Susan E, Ruiter, Ruud W J, Li, Fengzhi, Buijze, Marijke, Andersen, Morten N, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Lokhorst, Henk M, Zweegman, Sonja, Groen, Richard W J, Mutis, Tuna

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Bone Marrow Mesenchymal Stromal Cell‐mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38‐CAR or TRAIL‐variant by Holthof, Lisa C., Stikvoort, Arwen, Horst, Hilma J., Gelderloos, Anne T., Poels, Renée, Li, Fengzhi, Groen, Richard W. J., Zweegman, Sonja, Donk, Niels W. C. J., O'Dwyer, Michael, Mutis, Tuna

“…We have recently shown the strong negative impact of multiple myeloma (MM)‐bone marrow mesenchymal stromal cell (BMMSC) interactions to several…”
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Sepantronium bromide (YM155) improves daratumumab-mediated cellular lysis of multiple myeloma cells by abrogation of bone marrow stromal cell-induced resistance by de Haart, Sanne J, Holthof, Lisa, Noort, Willy A, Minnema, Monique C, Emmelot, Maarten E, Aarts-Riemens, Tineke, Doshi, Parul, Sasser, Kate, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C M, van de Donk, Niels W C J, Lokhorst, Henk M, Groen, Richard W J, Mutis, Tuna

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The Impact and Modulation of Microenvironment-Induced Immune Resistance Against CAR T Cell and Antibody Treatments in Multiple Myeloma by Holthof, Lisa C., Van Der Horst, Hilma J., Poels, Renée, van der Schans, Jort T., Gelderloos, Anne T., Li, Fengzhi, Lokhorst, Henk, Zweegman, Sonja, Themeli, Maria, Van De Donk, Niels W. C.J., Groen, Richard W.J., Mutis, Tuna

“…The tumor microenvironment of multiple myeloma (MM) is known to play a critical role in disease pathogenesis, MM cell survival, and drug resistance. In…”
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