Search Results - "Holte, Kimberly"

Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation by Beneduce, Christopher, Nguyen, Stephanie, Washburn, Nathaniel, Schaeck, John, Meccariello, Robin, Holte, Kimberly, Ortiz, Daniel, Manning, Anthony M., Bosques, Carlos J., Kurtagic, Elma

“…Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the…”
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Novel Method of Reducing Ketones Using Sodium Hydroxide in Isopropanol by Zuidema, Daniel R., Wert, Katherine J., Williams, Sarah L., Chill, Samuel T., Holte, Kimberly L., Kokes, Nathanael K., Mebane, Robert C.

“…Ketones are readily reduced to secondary alcohols with sodium hydroxide in refluxing isopropanol…”
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Characterization of Endogenous Human FcγRIII by Mass Spectrometry Reveals Site, Allele and Sequence Specific Glycosylation[S] by Washburn, Nathaniel, Meccariello, Robin, Duffner, Jay, Getchell, Kristen, Holte, Kimberly, Prod'homme, Thomas, Srinivasan, Karunya, Prenovitz, Robert, Lansing, Jonathan, Capila, Ishan, Kaundinya, Ganesh, Manning, Anthony M., Bosques, Carlos J.

“…Characterization of endogenous FcγRIII glycosylation from healthy donors with different FcγRIIIb genotypes reveals site specific, and allele specific…”
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Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors by Ortiz, Daniel F, Lansing, Jonathan C, Rutitzky, Laura, Kurtagic, Elma, Prod'homme, Thomas, Choudhury, Amit, Washburn, Nathaniel, Bhatnagar, Naveen, Beneduce, Christopher, Holte, Kimberly, Prenovitz, Robert, Child, Matthew, Killough, Jason, Tyler, Steven, Brown, Julia, Nguyen, Stephanie, Schwab, Inessa, Hains, Maurice, Meccariello, Robin, Markowitz, Lynn, Wang, Jing, Zouaoui, Radouane, Simpson, Allison, Schultes, Birgit, Capila, Ishan, Ling, Leona, Nimmerjahn, Falk, Manning, Anthony M, Bosques, Carlos J

“…Autoantibody immune complex (IC) activation of Fcγ receptors (FcγRs) is a common pathogenic hallmark of multiple autoimmune diseases. Given that the IC…”
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Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies by Roy, Sucharita, El Hadri, Ahmed, Richard, Sebastien, Denis, Fanny, Holte, Kimberly, Duffner, Jay, Yu, Fei, Galcheva-Gargova, Zoya, Capila, Ishan, Schultes, Birgit, Petitou, Maurice, Kaundinya, Ganesh V

“…To date, the structure–activity relationship studies of heparin/heparan sulfate with their diverse binding partners such as growth factors, cytokines,…”
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Characterization of heparin–protein interaction by saturation transfer difference (STD) NMR by Yu, Fei, Roy, Sucharita, Arevalo, Enrique, Schaeck, John, Wang, Jason, Holte, Kimberly, Duffner, Jay, Gunay, Nur Sibel, Capila, Ishan, Kaundinya, Ganesh V.

“…The binding affinity and specificity of heparin to proteins is widely recognized to be sulfation-pattern dependent. However, for the majority of…”
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Abstract 3244: Improved Fc-mediated effector functions by an anti-CTLA-4 multivalent Fc agent by Rutitzky, Laura, Ortiz, Daniel F., Lansing, Jonathan C., Brown, Julia, Paquette, Joseph, Garofalo, Kevin, D'Alessandro, Josephine, Bhatnagar, Naveen, Hains, Maurice, Gupta, Abhinav, Lee, Stan, Zouaoui, Radouane, Wang, Jason, Schaeck, John, Marchese, Salvatore, Meccariello, Robin, Washburn, Nathaniel, Holte, Kimberly, Bosques, Carlos J., Manning, Anthony M.

“…Numerous therapeutic monoclonal antibodies (mAbs) rely on antibody-dependent cell cytotoxicity (ADCC), antibody-dependent cell phagocytosis (ADCP) and…”
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Role of M402, a novel heparan sulfate mimetic, in pancreatic cancer cell invasion and metastasis: Inhibition of the Sonic Hedgehog pathway and heparanase activity by Galcheva-Gargova, Zoya, Chu, Chia Lin, Long, Alison, Duffner, Jay, Holte, Kimberly, Schultes, Birgit Corinna

“…Abstract only 25 Background: M402 is a novel heparin sulfate mimetic that binds to multiples growth factors, adhesion molecules, and cytokines to inhibit tumor…”
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Characterization of Endogenous Human FcγRIII by Mass Spectrometry Reveals Site, Allele and Sequence Specific Glycosylation by Washburn, Nathaniel, Meccariello, Robin, Duffner, Jay, Getchell, Kristen, Holte, Kimberly, Prod'homme, Thomas, Srinivasan, Karunya, Prenovitz, Robert, Lansing, Jonathan, Capila, Ishan, Kaundinya, Ganesh, Manning, Anthony M, Bosques, Carlos J

“…The importance of IgG glycosylation, Fc-gamma receptor (FcγR) single nucleotide polymorphisms and FcγR copy number variations in fine tuning the immune…”
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Transfer Hydrogenation of Ketones with 2-Propanol and Raney® Nickel by Mebane, Robert C., Holte, Kimberly L., Gross, Benjamin H.

“…Raney nickel in refluxing 2-propanol containing a trace of HCl is an effective catalytic system for the reduction of ketones to secondary alcohols…”
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An SPR‐based fragment mapping study on interleukin 2 (IL‐2) towards the development of small molecule inhibitors of protein‐protein interactions (PPIs) by Holte, Kimberly, Brenke, Ryan, Ochiana, Stefan, Karver, Caitlin, Kozakov, Dima, Vajda, Sandor, Allen, Karen, Pollastri, Michael, Whitty, Adrian

“…To better understand how to inhibit PPI targets with small molecules, we have developed a fragment‐based method for probing the IL‐2/IL‐2 receptor alpha…”
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