Search Results - "Holt, William F"

Ocular Hypotensive Response in Nonhuman Primates of (8R)‑1-[(2S)‑2-Aminopropyl]-8,9-dihydro‑7H‑pyrano[2,3‑g]indazol-8-ol a Selective 5‑HT2 Receptor Agonist by May, Jesse A, Sharif, Najam A, McLaughlin, Marsha A, Chen, Hwang-Hsing, Severns, Bryon S, Kelly, Curtis R, Holt, William F, Young, Richard, Glennon, Richard A, Hellberg, Mark R, Dean, Thomas R

“…Recently, it has been reported that 5-HT2 receptor agonists effectively reduce intraocular pressure (IOP) in a nonhuman primate model of glaucoma. Although…”
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Neural Losses Correlated with Visual Losses in Clinical Perimetry by Harwerth, Ronald S, Carter-Dawson, Louvenia, Smith, Earl L., III, Barnes, George, Holt, William F, Crawford, Morris L. J

“…The validity of clinical perimetry for evaluation of the pathology of glaucoma is based on correlated losses in retinal ganglion cells and visual sensitivity,…”
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Safety of Moxifloxacin as Shown in Animal and In Vitro Studies by McGee, David H., Holt, William F., Kastner, Philip R., Rice, Rebecca L.

“…Topical treatment of ocular bacterial infection is practiced widely, and the choice of the antibacterial agent depends on the nature of the infection,…”
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Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers by Padmanabhan, Seetharamaiyer, Lavin, Ruth C, Thakker, Paresh M, Guo, Jinqing, Zhang, Lu, Moore, Deke, Perlman, Michael E, Kirk, Cassandra, Daly, Deborah, Burke-Howie, Kathy J, Wolcott, Teresa, Chari, Suchitra, Berlove, David, Fischer, James B, Holt, William F, Durant, Graham J, McBurney, Robert N

“…Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are…”
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Ocular Hypotensive Response in Nonhuman Primates of (8 R )-1-[(2 S )-2-Aminopropyl]-8,9-dihydro-7 H -pyrano[2,3- g ]indazol-8-ol a Selective 5-HT 2 Receptor Agonist by May, Jesse A., Sharif, Najam A., McLaughlin, Marsha A., Chen, Hwang-Hsing, Severns, Bryon S., Kelly, Curtis R., Holt, William F., Young, Richard, Glennon, Richard A., Hellberg, Mark R., Dean, Thomas R.

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Comparison of angiotensin converting enzyme and renin inhibition in rats following myocardial infarction by Mento, P F, Maita, M E, Murphy, W R, Holt, W F, Wilkes, B M

“…Renal and systemic hemodynamics were studied in rats 1 month after induction of myocardial infarction by ligation of the left coronary artery. The mean…”
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Combined Renin and Converting Enzyme Inhibition in Rats by Mento, Peter F, Holt, William F, Murphy, William R, Wilkes, Barry M

“…The effects of combined renin inhibition and converting enzyme inhibition on mean arterial pressure and the plasma renin-angiotensin system were studied in…”
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Antiulcer agents. 4-Substituted 2-guanidinothiazoles: reversible, competitive, and selective inhibitors of gastric H+,K+-ATPase by LaMattina, John L, McCarthy, Peter A, Reiter, Lawrence A, Holt, William F, Yeh, Li An

“…A series of 4-substituted 2-guanidinothiazoles has been found to inhibit the gastric proton-pump enzyme H+,K(+)-ATPase. In general, these compounds were…”
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SDS purification of porcine H,K-ATPase from gastric mucosa by Yeh, L A, Cosgrove, P, Holt, W F

“…A highly purified membrane fraction of H,K-ATPase was isolated from hog gastric mucosa by using differential centrifugation, sodium dodecyl sulfate…”
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Safety of moxifloxacin as shown in animal and in vitro studies: The potency, ocular penetration, and safety of moxifloxacin (as VIGAMOX® solution), a topical ophthalmic fourth-generation fluoroquinolone by MCGEE, David H, HOLT, William F, KASTNER, Philip R, RICE, Rebecca L

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Central DuP 753 does not lower blood pressure in spontaneously hypertensive rats by DEPASQUALE, M. J, FOSSA, A. A, HOLT, W. F, MANGIAPANE, M. L

“…Oral administration of the angiotensin II receptor subtype 1 (AT1) antagonist DuP 753 causes long-lasting lowering of mean arterial pressure in spontaneously…”
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Discovery of inhibitors of human renin with high oral bioavailability by Hoover, D J, Lefker, B A, Rosati, R L, Wester, R T, Kleinman, E F, Bindra, J S, Holt, W F, Murphy, W R, Mangiapane, M L, Hockel, G M

“…Knowledge of the sequence of a bioactive protein (angiotensinogen) and the availability of a natural product inhibitor lead (pepstatin) were the starting point…”
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CP-66,948 : an antisecretory histamine H2-receptor antagonist with mucosal protective properties by HAKKINEN, J. P, HOLT, W. F, GODDARD, C. J, OATES, P. J, MURPHY, W. R, MACIEJKO, J. J, REITER, L. A

“…CP-66,948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties. The affinity of CP-66,948 for the guinea…”
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