Search Results - "Holt, Vance"

The enigmatic role of HLA-B27 in spondyloarthritis pathogenesis by Navid, Fatemeh, Holt, Vance, Colbert, Robert A.

“…Establishing a clear role for HLA-B*27 in the pathogenesis of spondyloarthritis continues to be challenging. Aberrant properties of the heavy chain as well as…”
Get full text

The Janus kinases (Jaks) by Yamaoka, Kunihiro, Saharinen, Pipsa, Pesu, Marko, Holt, 3rd, Vance E T, Silvennoinen, Olli, O'Shea, John J

“…The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3…”
Get full text

Identification of a subpopulation of marrow MSC-derived medullary adipocytes that express osteoclast-regulating molecules: marrow adipocytes express osteoclast mediators by Holt, Vance, Caplan, Arnold I, Haynesworth, Stephen E

“…Increased marrow medullary adipogenesis and an associated decrease in bone mineral density, usually observed in elderly individuals, is a common characteristic…”
Get full text

IL-22 Effects on Osteoblast Mineralization and Metabolic Profile by Holt, Vance E, Luo, Yongquan, Colbert, Robert A

“…Abstract Ankylosing spondylitis (AS) is an immune-mediated inflammatory disease characterized by persistent entheseal inflammation and aberrant bone formation…”
Get full text

Acute cytokine treatment stimulates glucose uptake and glycolysis in human keratinocytes by Holt, Vance, Morén, Björn, Fryklund, Claes, Colbert, Robert A., Stenkula, Karin G

“…During inflammation, cellular glucose uptake and glycolysis are upregulated to meet an increased energy demand. For example, keratinocyte glycolysis is…”
Get full text

Paradoxical Effects of Endoplasmic Reticulum Aminopeptidase 1 Deficiency on HLA–B27 and Its Role as an Epistatic Modifier in Experimental Spondyloarthritis by Tran, Tri M., Gill, Tejpal, Bennett, Joshua, Hong, Sohee, Holt, Vance, Lindstedt, Anders J., Bakshi, Sufia, Sikora, Keith, Taurog, Joel D., Breban, Maxime, Navid, Fatemeh, Colbert, Robert A.

“…Objective We undertook this study to examine the functional basis for epistasis between endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA–B27 in…”
Get full text

ERAP1 deficiency mitigates HLA-B27 misfolding and ER stress, and protects HLA-B27 transgenic rats from arthritis and orchitis by Tran, Tri M, Gill, Tejpal, Bennett, Joshua, Holt, Vance, Hong, Sohee, Taurog, Joel D, Colbert, Robert A

“…Abstract Endoplasmic reticulum aminopeptidase 1 (ERAP1) is associated with ankylosing spondylitis (AS) in HLA-B27-positive individuals. ERAP1 optimizes peptide…”
Get full text