Search Results - "Holt, PG"

Parasites, atopy, and the hygiene hypothesis: resolution of a paradox? by Holt, Patrick G

“…The hygiene hypothesis arose from attempts to explain differences in allergy prevalence related to socioeconomic and geographical factors. Its major focus has…”
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A potential vaccine strategy for asthma and allied atopic diseases during early childhood by Holt, P G

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Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood by Holt, P G

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Association between antenatal cytokine production and the development of atopy and asthma at age 6 years by Macaubas, C, de Klerk, NH, Holt, BJ, Wee, C, Kendall, G, Firth, M, Sly, PD, Holt, PG

“…Various lines of evidence suggest that antenatal factors are important in determining susceptibility to atopy and asthma. One possible mechanism is cytokines,…”
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Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages by Tarique, Abdullah A, Logan, Jayden, Thomas, Emma, Holt, Patrick G, Sly, Peter D, Fantino, Emmanuelle

“…Macrophages are dynamic cells that mature under the influence of signals from the local microenvironment into either classically (M1) or alternatively (M2)…”
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Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence by Holt, P G, Clough, J B, Holt, B J, Baron-Hay, M J, Rose, A H, Robinson, B W, Thomas, W R

“…Recent in vitro studies suggest that IgE production in adults is co-ordinately regulated by negative signals from gamma IFN-producing CD4+ T-helper-1 (TH-1)…”
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Meta-analysis identifies seven susceptibility loci involved in the atopic march by Marenholz, Ingo, Esparza-Gordillo, Jorge, Rüschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjörg, Margaritte-Jeannin, Patricia, Sääf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Söderhäll, Cilla, Pershagen, Göran, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrländer, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven, Nöthen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias, Hübner, Norbert, Holt, Patrick G., Lau, Susanne, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melén, Erik, Dizier, Marie- Hélène, Henderson, A John, Lee, Young Ae

“…Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of…”
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Distinguishing benign from pathologic TH2 immunity in atopic children by Holt, Patrick G., Strickland, Deborah, Bosco, Anthony, Belgrave, Danielle, Hales, Belinda, Simpson, Angela, Hollams, Elysia, Holt, Barbara, Kusel, Merci, Ahlstedt, Staffan, Sly, Peter D., Custovic, Adnan

“…Although most children with asthma and rhinitis are sensitized to aeroallergens, only a minority of sensitized children are symptomatic, implying the…”
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Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4 by Grosche, Sarah, Marenholz, Ingo, Esparza-Gordillo, Jorge, Arnau-Soler, Aleix, Pairo-Castineira, Erola, Rüschendorf, Franz, Ahluwalia, Tarunveer S., Almqvist, Catarina, Arnold, Andreas, Baurecht, Hansjörg, Bisgaard, Hans, Bønnelykke, Klaus, Brown, Sara J., Bustamante, Mariona, Curtin, John A., Custovic, Adnan, Dharmage, Shyamali C., Esplugues, Ana, Falchi, Mario, Fernandez-Orth, Dietmar, Ferreira, Manuel A. R., Franke, Andre, Gerdes, Sascha, Gieger, Christian, Hakonarson, Hakon, Holt, Patrick G., Homuth, Georg, Hubner, Norbert, Hysi, Pirro G., Jarvelin, Marjo-Riitta, Karlsson, Robert, Koppelman, Gerard H., Lau, Susanne, Lutz, Manuel, Magnusson, Patrik K. E., Marks, Guy B., Müller-Nurasyid, Martina, Nöthen, Markus M., Paternoster, Lavinia, Pennell, Craig E., Peters, Annette, Rawlik, Konrad, Robertson, Colin F., Rodriguez, Elke, Sebert, Sylvain, Simpson, Angela, Sleiman, Patrick M. A., Standl, Marie, Stölzl, Dora, Strauch, Konstantin, Szwajda, Agnieszka, Tenesa, Albert, Thompson, Philip J., Ullemar, Vilhelmina, Visconti, Alessia, Vonk, Judith M., Wang, Carol A., Weidinger, Stephan, Wielscher, Matthias, Worth, Catherine L., Xu, Chen-Jian, Lee, Young-Ae

“…Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we…”
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Early identification of atopy in the prediction of persistent asthma in children by Sly, Peter D, Prof, Boner, Attilio L, Prof, Björksten, Bengt, Prof, Bush, Andy, Prof, Custovic, Adnan, Prof, Eigenmann, Philippe A, Prof, Gern, James E, Prof, Gerritsen, Jorrit, Prof, Hamelmann, Eckard, Prof, Helms, Peter J, Prof, Lemanske, Robert F, Prof, Martinez, Fernando, Prof, Pedersen, Soren, Prof, Renz, Harald, Prof, Sampson, Hugh, Prof, von Mutius, Erika, Prof, Wahn, Ulrich, Prof, Holt, Patrick G, Prof

“…Summary The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from…”
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Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop by Bousquet, Jean, MD, Gern, James E., MD, Martinez, Fernando D., MD, Anto, Josep M., MD, PhD, Johnson, Christine C., PhD, MPH, Holt, Patrick G., ScD, Lemanske, Robert F., MD, Le Souëf, Peter N., MD, Tepper, Robert S., MD, PhD, von Mutius, Erika R.M., MD, MSc, Arshad, S. Hasan, DM, Bacharier, Leonard B., MD, Becker, Allan, MD, Belanger, Kathleen, PhD, Bergström, Anna, PhD, Bernstein, David I., MD, Cabana, Michael D., MD, MPH, Carroll, Kecia N., MD, MPH, Castro, Mario, MD, MPH, Cooper, Philip J., PhD, Gillman, Matthew W., MD, SM, Gold, Diane R., MD, MPH, Henderson, John, MD, Heinrich, Joachim, PhD, MSc, Hong, Soo-Jong, MD, PhD, Jackson, Daniel J., MD, Keil, Thomas, MD, MSc, Kozyrskyj, Anita L., PhD, Lødrup Carlsen, Karin C., MD, PhD, Miller, Rachel L., MD, Momas, Isabelle, PhD, Morgan, Wayne J., MD, CM, Noel, Patricia, PhD, Ownby, Dennis R., MD, Pinart, Mariona, PhD, Ryan, Patrick H., PhD, Schwaninger, Julie M., MS, Sears, Malcolm R., MB, ChB, Simpson, Angela, MD, PhD, Smit, Henriette A., PhD, Stern, Debra A., MS, Subbarao, Padmaja, MD, MSc, Valenta, Rudolf, MD, Wang, Xiaobin, MD, MPH, ScD, Weiss, Scott T., MD, MS, Wood, Robert, MD, Wright, Anne L., PhD, Wright, Rosalind J., MD, MPH, Togias, Alkis, MD, Gergen, Peter J., MD, MPH

“…Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases. More than…”
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Contemporaneous maturation of immunologic and respiratory functions during early childhood: Implications for development of asthma prevention strategies by Holt, Patrick G., Upham, John W., Sly, Peter D.

“…The term asthma refers to a spectrum of wheezing syndromes resulting from airways inflammation triggered by a range of environmental stimuli, the most…”
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Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: A randomized, controlled trial by Dunstan, Janet A, Mori, Trevor A, Barden, Anne, Beilin, Lawrence J, Taylor, Angie L, Holt, Patrick G, Prescott, Susan L

“…There is growing interest in the potential role of anti-inflammatory n-3 polyunsaturated fatty acids (n-3 PUFAs) in the prevention of allergic disease. We…”
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Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells by White, Gregory P, Watt, Paul M, Holt, Barbara J, Holt, Patrick G

“…IFN-gamma is a potent pleiotropic Th1 cytokine, the production of which is tightly regulated during fetal development. Negative control of fetal/neonatal…”
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Anatomical Location Determines the Distribution and Function of Dendritic Cells and Other APCs in the Respiratory Tract by von Garnier, Christophe, Filgueira, Luis, Wikstrom, Matthew, Smith, Miranda, Thomas, Jennifer A, Strickland, Deborah H, Holt, Patrick G, Stumbles, Philip A

“…APCs, including dendritic cells (DC), are central to Ag surveillance in the respiratory tract (RT). Research in this area is dominated by mouse studies on…”
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Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study by Holt, Patrick G., FAA, Rowe, Julie, PhD, Kusel, Merci, MBBS, Parsons, Faith, BSc, Hollams, Elysia M., PhD, Bosco, Anthony, PhD, McKenna, Kathy, PhD, Subrata, Lily, PhD, de Klerk, Nicholas, PhD, Serralha, Michael, BSc(Hons), Holt, Barbara J., BSc, Zhang, Guicheng, PhD, Loh, Richard, FRACP, Ahlstedt, Staffan, PhD, Sly, Peter D., FRACP

“…Background Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk…”
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Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis by Thyssen, Jacob P., Ahluwalia, Tarunveer S., Paternoster, Lavinia, Ballardini, Natalia, Bergström, Anna, Melén, Erik, Chawes, Bo L., Stokholm, Jakob, Hourihane, Jonathan O'B, O'Sullivan, Donnchadh M., Bager, Peter, Melbye, Mads, Bustamante, Mariona, Torrent, Maties, Esplugues, Ana, Duijts, Liesbeth, Hu, Chen, Elbert, Niels J., Pasmans, Suzanne G. M. A., Nijsten, Tamar E. C., Berg, Andrea, Standl, Marie, Schikowski, Tamara, Herberth, Gunda, Heinrich, Joachim, Lee, Young‐Ae, Marenholz, Ingo, Lau, Susanne, Curtin, John A., Simpson, Angela, Custovic, Adnan, Pennell, Craig E., Wang, Carol A., Holt, Patrick G., Bisgaard, Hans, Bønnelykke, Klaus

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Distinguishing benign from pathologic T H 2 immunity in atopic children by Holt, PG, Strickland, D, Bosco, A, Belgrave, D, Hales, B, Simpson, A, Hollams, E, Holt, B, Kusel, M, Ahlstedt, S

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Maternal smoking in pregnancy alters neonatal cytokine responses by Noakes, P. S., Holt, P. G., Prescott, S. L.

“…Background: Maternal cigarette smoking in pregnancy is an important, common and avoidable exposure that has been linked with elevated cord blood (CB)…”
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The development of the immune system during pregnancy and early life by Holt, P. G., Jones, C. A.

“…It is a common misconception that the newborn is immunologically naive. However, neonatal human T cells proliferate in response to an array of antigens,…”
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