Search Results - "Holt, Jonathon"

Acceptability and preferences for vaginal dosage forms intended for prevention of HIV or HIV and pregnancy by Woodsong, Cynthia, Holt, Jonathon D.S.

“…This paper reviews key issues found to affect acceptability and preferences for vaginal products to prevent HIV infection or HIV and pregnancy. We focus on the…”
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The sheep as a model of preclinical safety and pharmacokinetic evaluations of candidate microbicides by Holt, Jonathon D S, Cameron, David, Dias, Nicola, Holding, Jeremy, Muntendam, Alex, Oostebring, Freddy, Dreier, Peter, Rohan, Lisa, Nuttall, Jeremy

“…When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical…”
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A case of multifocal stroke—the first presentation of underlying ovarian malignancy by Holt, Jonathon N

“…Abstract Ischaemic stroke is a rare manifestation of hypercoagulability induced by underlying malignancy. It is proposed that paraneoplastic non-bacterial…”
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Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device by Murphy, Diarmaid J., Boyd, Peter, McCoy, Clare F., Kumar, Sandeep, Holt, Jonathon D.S., Blanda, Wendy, Brimer, Andrew N., Malcolm, R. Karl

“…Despite a long history of incorporating steroids into silicone elastomers for drug delivery applications, little is presently known about the propensity for…”
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A case of splenic artery pseudoaneurysm rupture presenting as rectal bleeding in a regional hospital by Holt, Jonathon N, Schwalb, Heinrich E

“…Abstract Splenic artery pseudoaneurysm is a rare phenomenon most associated with chronic pancreatitis or previous trauma. Complications can include erosion and…”
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Preclinical safety evaluation by Holt, Jonathon D S, Nuttall, Jeremy P

“…Before pharmaceutical products are evaluated in humans, it is essential that they undergo a rigorous safety assessment using in vitro models and studies in…”
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Weight loss and complications of the banded Roux-en-Y gastric bypass: lessons learned from a prospective case control study by Skidmore, Adam, Holt, Jonathon

“…Objective Obesity is a growing global health burden which is particularly challenging to manage. Bariatric surgery is considered the most effective means of…”
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Spontaneous haemorrhage of chronic varicose ulceration causing ischaemic colitis by Holt, Jonathon

“…Abstract Venous ulcers are common and account for the majority of lower limb chronic wounds. Complications may be serious in nature and although haemorrhage is…”
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ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic acid], a novel nonpeptide delta receptor agonist, reduces myocardial infarct size without central effects by Watson, Michael J, Holt, Jonathon D S, O'Neill, Scott J, Wei, Ke, Pendergast, William, Gross, Garrett J, Gengo, Peter J, Chang, Kwen-Jen

“…A novel delta-receptor selective compound, ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,…”
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DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats by Holt, Jonathon D S, Watson, Michael J, Chang, Jane P, O'Neill, Scott J, Wei, Ke, Pendergast, William, Gengo, Peter J, Chang, Kwen-Jen

“…There is a wealth of information from animal models and clinical opioid-analgesic use that indicates a significant role for opioid receptors in the modulation…”
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Risk factors for recurrence in colorectal cancer: a retrospective analysis in a regional Australian hospital by Holt, Jonathon, Schwalb, Heinrich, Elbourne, Hugh, te Marvelde, Luc, Reid, Caitlin

“…Background Colorectal cancer is the third most commonly diagnosed malignancy in Australia. Up to a third of patients who have undergone surgery with curative…”
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Studies on a model of long term alcohol drinking by Holt, Jonathon D.S, Watson, William P, Little, Hilary J

“…This study investigated the effects of a dihydropyridine calcium channel antagonist in a free drinking model [7] previously reported to show increased and…”
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Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel by Boyd, Peter, Fetherston, Susan M., McCoy, Clare F., Major, Ian, Murphy, Diarmaid J., Kumar, Sandeep, Holt, Jonathon, Brimer, Andrew, Blanda, Wendy, Devlin, Brid, Malcolm, R. Karl

“…[Display omitted] A matrix-type silicone elastomer vaginal ring providing 28-day continuous release of dapivirine (DPV) ⿿ a lead candidate human…”
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Pharmacokinetic/Pharmacodynamic Analysis of Amantadine for Levodopa-Induced Dyskinesia: Correlation of Therapeutic Plasma Concentrations from Multiple Species with Humans (S45.006) by Brigham, Elizabeth, Johnston, Tom, Brown, Carl, Holt, Jonathon, Fox, Susan, Howson, Patrick, Brotchie, Jonathan, Nguyen, Jack

“…Abstract only…”
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Extended-release (ER) formulations of aminoadamantanes as NMDA-receptor antagonists: pharmacokinetic (PK) determinants of improved tolerability (P5.064) by Nguyen, Jack, Fultz, Timothy, Davis, Charles, Patni, Rajiv, Brigham, Elizabeth, Holt, Jonathon, Went, Gregory

“…Abstract only…”
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Pre-existing hiatal mesh increases morbidity during and after revisional antireflux surgery: A retrospective multicenter study by Liu, David S, Allan, Zexi, Wong, Darren J, Goh, Su Kah, Stevens, Sean, Aly, Ahmad, Bright, Tim, Watson, David I

“…Revisional antireflux surgery, including hiatus hernia repair, is increasingly common. Mesh-augmented hiatal closure at the time of index operation is…”
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Current Status of Multipurpose Prevention Technology (MPT) Development by Woodsong, Cynthia, Holt, Jonathon, Devlin, Brid, Rosenberg, Zeda

“…Multipurpose prevention technologies (MPTs) are pharmaceutical products being developed for multiple indications, primarily prevention of HIV, pregnancy,…”
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Effect of timing of perioperative chemical thromboprophylaxis on thromboembolic, bleeding, and other complications during and after antireflux surgery: multicentre cohort study by Liu, David S, Wong, Darren J, Goh, Su Kah, Watson, David I, Wong, Enoch, Fong, Jonathan, Stevens, Sean, Aly, Ahmad, Muralidharan, Vijayaragavan, Kalogeropoulos, George, Liew, Chon Hann, Kariyawasam, Sanjeeva, Cashin, Paul, Mori, Krinal, Read, Matthew, Bright, Tim, Cichowitz, Adam, Yeung, Justin, Cox, Daniel, Holt, Jonathon, Jinnaah, Sara Mohammed, Crowe, Amy, Vu, Anh N, Idrees, Marwan, Ooi, Geraldine, Lee, Sharon, Chong, Lynn, Downie, Emma, Lauritz, Brianne, Ashraf, Hamza, Maung, Hein, Alukaidey, Lobna, Wong, Samantha, Gill, Sonia, Jamel, Wael, Reid, Caitlin, Elbourne, Hugh, Hughes, Jed, Doole, Emily, Lirios, Gabriel, Anandan, Manoj, Sankpal, Shipra, Zhang, Zoe, Larner, Brett, Fitt, Emily, Paynter, Jessica, Chen, Nevin, Nasser, Ra, Ibrahim, Joe, Hilder, Amie, Aksakal, Gamze, Cheung, King Tung, Joglekar, Shantanu, Leathersich, Amy, Lee, Deanna, Lu, Thuc Nhi, Qian, Wanyang, Palanisamy, Vigneshkumar, Rajagopalan, Ashray, Menzie, Jack, Singh, Jasprit, Lim, Sean, Su, Sandy, Choong, Emma, Gray, James, Cherry, Tiffany, Nadaraja, Roshini, May, James, McCafferty, Jonathan, Lee, Jordan, Wilkinson, Sally, Choi, Cheuk Shan, Ho, Felicia Ching Siew, Qiao, Jing, Sasanelli, Francesca, Bennett, Kyle, Fairweather, Luke, Zaman, Tazvir, Santucci, Walter, Jayapadman, Vivek

“…Abstract Background Although guidelines recommend the use of perioperative chemical thromboprophylaxis for antireflux surgery, the optimal timing for its…”
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Spontaneous haemorrhage of chronic varicose ulceration causing ischaemic colitis by Holt, Jonathon

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A case of multifocal stroke-the first presentation of underlying ovarian malignancy by Holt, Jonathon N

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