Search Results - "Holt, JA"

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis by Holt, Jason A, Luo, Guizhen, Billin, Andrew N, Bisi, John, McNeill, Y Yvette, Kozarsky, Karen F, Donahee, Mary, Wang, Da Yuan, Mansfield, Traci A, Kliewer, Steven A, Goodwin, Bryan, Jones, Stacey A

“…The nuclear bile acid receptor FXR has been proposed to play a central role in the feedback repression of the gene encoding cholesterol 7 alpha-hydroxylase…”
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Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors by Oakley, Robert H., Laporte, Stéphane A., Holt, Jason A., Caron, Marc G., Barak, Larry S.

“…Visual arrestin, βarrestin1, and βarrestin2 comprise a family of intracellular proteins that desensitize G protein-coupled receptors (GPCRs). In addition,…”
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Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis by Oakley, Robert H., Laporte, Stéphane A., Holt, Jason A., Barak, Larry S., Caron, Marc G.

“…β-Arrestins bind agonist-activated G protein-coupled receptors (GPCRs) and mediate their desensitization and internalization. Although β-arrestins dissociate…”
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Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization by Oakley, Robert H., Laporte, Stéphane A., Holt, Jason A., Barak, Larry S., Caron, Marc G.

“…Resensitization of G protein-coupled receptors (GPCRs) following agonist-mediated desensitization is a necessary step for maintaining physiological…”
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A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor[boxs] by Bledsoe, Randy K., Madauss, Kevin P., Holt, Jason A., Apolito, Christopher J., Lambert, Millard H., Pearce, Kenneth H., Stanley, Thomas B., Stewart, Eugene L., Trump, Ryan P., Willson, Timothy M., Williams, Shawn P.

“…Ligand binding is the first step in hormone regulation of mineralocorticoid receptor (MR) activity. Here, we report multiple crystal structures of MR (NR3C2)…”
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Steroidogenic Factor 1-Dependent Promoter Activity of the Human Steroidogenic Acute Regulatory Protein (StAR) Gene by Sugawara, Teruo, Holt, John A, Kiriakidou, Marianthi, Strauss, Jerome F

“…Steroidogenic acute regulatory protein (StAR) is required for efficient adrenal cortical and gonadal but not trophoblast steroid hormone synthesis. StAR gene…”
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Steroidogenic Acute Regulatory Protein (StAR) Retains Activity in the Absence of Its Mitochondrial Import Sequence: Implications for the Mechanism of StAR Action by Arakane, Futoshi, Sugawara, Teruo, Nishino, Hideaki, Liu, Zhiming, Holt, John A., Pain, Debkumar, Stocco, Douglas M., Miller, Walter L., Strauss, Jerome F.

“…Steroidogenic acute regulatory protein (StAR) plays a critical role in steroid hormone biosynthesis, presumably by facilitating the delivery of cholesterol to…”
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Grazing pressure and soil carbon, microbial biomass and enzyme activities in semi-arid northeastern Australia by Holt, J.A.

“…The effects of cattle grazing pressure on total carbon, microbial biomass carbon levels and selected enzyme activities of the soils at several sites in…”
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Quantification of the effects of rotation breaks on soil biological properties and their impact on yield decline in sugarcane by Pankhurst, C.E., Stirling, G.R., Magarey, R.C., Blair, B.L., Holt, J.A., Bell, M.J., Garside, A.L.

“…Three contrasting rotation breaks (sown pasture, alternate crops and bare fallow) were established at five sites in Queensland, Australia, on land that had…”
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Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13 by T Sugawara, J A Holt, D Driscoll, J F Strauss, 3rd, D Lin, W L Miller, D Patterson, K P Clancy, I M Hart, B J Clark

“…Steroidogenic acute regulatory protein (StAR) appears to mediate the rapid increase in pregnenolone synthesis stimulated by tropic hormones. cDNAs encoding…”
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Ionospheric plasma temperatures during 1976–2001 over Millstone Hill by Zhang, Shun-Rong, Holt, John M.

“…Incoherent scatter measurements have been made since the 1960s over Millstone Hill. Zenith antenna data since 1976 and steerable antenna data since 1980 are…”
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Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity by Sugawara, T, Lin, D, Holt, J A, Martin, K O, Javitt, N B, Miller, W L, Strauss, 3rd, J F

“…Steroidogenic acute regulatory protein (StAR) plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. We…”
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Studies of the HER-2/neu Proto-Oncogene in Human Breast and Ovarian Cancer by Slamon, Dennis J., Godolphin, William, Jones, Lovell A., Holt, John A., Wong, Steven G., Keith, Duane E., Levin, Wendy J., Stuart, Susan G., Udove, Judy, Ullrich, Axel, Michael F. Press

“…Carcinoma of the breast and ovary account for one-third of all cancers occurring in women and together are responsible for approximately one-quarter of…”
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Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity by Stanley, Thomas B, Leesnitzer, Lisa M, Montana, Valerie G, Galardi, Cristin M, Lambert, Millard H, Holt, Jason A, Xu, H. Eric, Moore, Linda B, Blanchard, Steven G, Stimmel, Julie B

“…Natural ligands for nuclear receptors are believed to activate gene transcription by causing dissociation of corepressors and promoting the association of…”
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Grazing impacts on the spatial distribution of soil microbial biomass around tussock grasses in a tropical grassland by Northup, B.K., Brown, J.R., Holt, J.A.

“…The role of grass tussocks in supporting soil microbial biomass (SMB) in grazed ecosystems is not fully understood, nor is the spatial distribution of SMB in…”
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Microbial activity in the mounds of some Australian termites by Holt, J.A

“…In this study I have measured the microbial biomass of soil and stored food material in the mounds of six northeastern Australian termite species using a…”
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T-->A transversion 11 bp from a splice acceptor site in the human gene for steroidogenic acute regulatory protein causes congenital lipoid adrenal hyperplasia by Tee, M K, Lin, D, Sugawara, T, Holt, J A, Guiguen, Y, Buckingham, B, Strauss, 3rd, J F, Miller, W L

“…Congenial lipoid adrenal hyperplasia (lipoid CAH) is the most severe form of CAH. Affected individuals can make no adrenal or gonadal steroids. All affected…”
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Transmembrane Protein Insertion Orientation in Yeast Depends on the Charge Difference across Transmembrane Segments, Their Total Hydrophobicity, and Its Distribution by Harley, Carol A., Holt, Jonathan A., Turner, Rhiannon, Tipper, Donald J.

“…The determinants of transmembrane protein insertion orientation at the endoplasmic reticulum have been investigated in Saccharomyces cerevisiae using variants…”
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The InDeVal insertion/deletion evaluation tool: a program for finding target regions in DNA sequences and for aiding in sequence comparison by Stoneberg Holt, Sierra D, Holt, Jason A

“…The program InDeVal was originally developed to help researchers find known regions of insertion/deletion activity (with the exception of isolated single-base…”
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Addition of casein or whey protein to colostrum or a colostrum supplement product on absorption of IgG in neonatal calves by Davenport, D F, Quigley, 3rd, J D, Martin, J E, Holt, J A, Arthington, J D

“…The effects of the addition of nonimmunoglobulin protein on absorption of immunoglobulin G (IgG) from colostrum or colostrum supplement products were…”
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