Search Results - "Holst, Stephanie"

Glycosylation Characteristics of Colorectal Cancer by Holst, Stephanie, Wuhrer, Manfred, Rombouts, Yoann

“…Glycans on proteins and lipids are known to alter with malignant transformation. The study of these may contribute to the discovery of biomarkers and treatment…”
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Protein Mannosylation as a Diagnostic and Prognostic Biomarker of Lupus Nephritis: An Unusual Glycan Neoepitope in Systemic Lupus Erythematosus by Alves, Inês, Santos‐Pereira, Beatriz, Dalebout, Hans, Santos, Sofia, Vicente, Manuel M., Campar, Ana, Thepaut, Michel, Fieschi, Franck, Strahl, Sabine, Boyaval, Fanny, Vizcaíno, Ramon, Silva, Roberto, Holst‐Bernal, Stephanie, Vasconcelos, Carlos, Santos, Lélita, Wuhrer, Manfred, Marinho, António, Heijs, Bram, Pinho, Salomé S.

“…Objective Changes in protein glycosylation are a hallmark of immune‐mediated diseases. Glycans are master regulators of the inflammatory response and are…”
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The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses by Jongsma, Marlieke L.M., de Waard, Antonius A., Raaben, Matthijs, Zhang, Tao, Cabukusta, Birol, Platzer, René, Blomen, Vincent A., Xagara, Anastasia, Verkerk, Tamara, Bliss, Sophie, Kong, Xiangrui, Gerke, Carolin, Janssen, Lennert, Stickel, Elmer, Holst, Stephanie, Plomp, Rosina, Mulder, Arend, Ferrone, Soldano, Claas, Frans H.J., Heemskerk, Mirjam H.M., Griffioen, Marieke, Halenius, Anne, Overkleeft, Hermen, Huppa, Johannes B., Wuhrer, Manfred, Brummelkamp, Thijn R., Neefjes, Jacques, Spaapen, Robbert M.

“…HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens…”
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Linkage-Specific in Situ Sialic Acid Derivatization for N‑Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues by Holst, Stephanie, Heijs, Bram, de Haan, Noortje, van Zeijl, René J. M, Briaire-de Bruijn, Inge H, van Pelt, Gabi W, Mehta, Anand S, Angel, Peggy M, Mesker, Wilma E, Tollenaar, Rob A, Drake, Richard R, Bovée, Judith V. M. G, McDonnell, Liam A, Wuhrer, Manfred

“…Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging is a rapidly evolving field in which mass spectrometry techniques are applied…”
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Multimodal Mass Spectrometry Imaging of N‑Glycans and Proteins from the Same Tissue Section by Heijs, Bram, Holst, Stephanie, Briaire-de Bruijn, Inge H., van Pelt, Gabi W., de Ru, Arnoud H., van Veelen, Peter A., Drake, Richard R., Mehta, Anand S., Mesker, Wilma E., Tollenaar, Rob A., Bovée, Judith V. M. G., Wuhrer, Manfred, McDonnell, Liam A.

“…On-tissue digestion matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can be used to record spatially correlated molecular…”
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Use of the Revised Second Victim Experience and Support Tool to Examine Second Victim Experiences of Respiratory Therapists by Allender, Erica A, Bottema, Sophia M, Bosley, Christopher L, Holst, Stephanie J, Clark, William J, Weaver, Amy L, Rivera-Chiauzzi, Enid Y, Finney, Robyn E

“…Respiratory therapists (RTs) work alongside allied health staff, nurses, and physicians during stressful and traumatic events that can be associated with…”
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Two-Dimensional N-Glycan Distribution Mapping of Hepatocellular Carcinoma Tissues by MALDI-Imaging Mass Spectrometry by Powers, Thomas W, Holst, Stephanie, Wuhrer, Manfred, Mehta, Anand S, Drake, Richard R

“…A new mass spectrometry imaging approach to simultaneously map the two-dimensional distribution of N-glycans in tissues has been recently developed. The method…”
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Investigations on Aberrant Glycosylation of Glycosphingolipids in Colorectal Cancer Tissues Using Liquid Chromatography and Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) by Holst, Stephanie, Stavenhagen, Kathrin, Balog, Crina I.A., Koeleman, Carolien A.M., McDonnell, Liam M., Mayboroda, Oleg A., Verhoeven, Aswin, Mesker, Wilma E., Tollenaar, Rob A.E.M., Deelder, André M., Wuhrer, Manfred

“…Cancer is a leading cause of death and alterations of glycosylation are characteristic features of malignant cells. Colorectal cancer is one of the most common…”
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N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines by Holst, Stephanie, Wilding, Jennifer L, Koprowska, Kamila, Rombouts, Yoann, Wuhrer, Manfred

“…The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut…”
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Serum sialylation changes in cancer by Zhang, Zejian, Wuhrer, Manfred, Holst, Stephanie

“…Cancer is a major cause of death in both developing and developed countries. Early detection and efficient therapy can greatly enhance survival. Aberrant…”
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Publications Are Not the Finish Line: Focusing on Societal Rather Than Publication Impact by Kools, Farah R W, Mirali, Sara, Holst-Bernal, Stephanie, Nijhof, Sanne L, Cavalli, Giulio, Grandner, Michael A

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Funders need to credit open science by de Jonge, Hans, Cruz, Maria, Holst, Stephanie

“…Letter to the Editor…”
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Serum protein N-glycosylation changes in multiple myeloma by Zhang, Zejian, Westhrin, Marita, Bondt, Albert, Wuhrer, Manfred, Standal, Therese, Holst, Stephanie

“…Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation…”
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Profiling of different pancreatic cancer cells used as models for metastatic behaviour shows large variation in their N-glycosylation by Holst, Stephanie, Belo, Ana I., Giovannetti, Elisa, van Die, Irma, Wuhrer, Manfred

“…To characterise pancreatic cancer cells from different sources which are used as model systems to study the metastatic behaviour in pancreatic ductal…”
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N-Glycomic Signature of Stage II Colorectal Cancer and Its Association With the Tumor Microenvironment by Boyaval, Fanny, van Zeijl, René, Dalebout, Hans, Holst, Stephanie, van Pelt, Gabi, Fariña-Sarasqueta, Arantza, Mesker, Wilma, Tollenaar, Rob, Morreau, Hans, Wuhrer, Manfred, Heijs, Bram

“…The choice for adjuvant chemotherapy in stage II colorectal cancer is controversial as many patients are cured by surgery alone and it is difficult to identify…”
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Presidents of Royal Society live long lives by Wilson, Oscar S., Huppert, Herbert E.

“…Letter to the Editor…”
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Transforming growth factor-β challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells by Zhang, Jing, Zhang, Zejian, Holst, Stephanie, Blöchl, Constantin, Madunic, Katarina, Wuhrer, Manfred, ten Dijke, Peter, Zhang, Tao

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and high mortality. Transforming growth factor-β (TGF-β) plays a key role in PDAC…”
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Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype by Madunić, Katarina, Zhang, Tao, Mayboroda, Oleg A., Holst, Stephanie, Stavenhagen, Kathrin, Jin, Chunsheng, Karlsson, Niclas G., Lageveen-Kammeijer, Guinevere S. M., Wuhrer, Manfred

“…Alterations in protein glycosylation in colorectal cancer (CRC) have been extensively studied using cell lines as models. However, little is known about their…”
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High-resolution crystal structures of two prototypical β- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity by Muller, Yves A., Häge, Sigrun, Alkhashrom, Sewar, Höllriegl, Tobias, Weigert, Sebastian, Dolles, Simon, Hof, Kerstin, Walzer, Sascha A., Egerer-Sieber, Claudia, Conrad, Marcus, Holst, Stephanie, Lösing, Josephine, Sonntag, Eric, Sticht, Heinrich, Eichler, Jutta, Marschall, Manfred

“…Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric basic structure of the nuclear egress complex (core…”
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Monoclonal immunoglobulins promote bone loss in multiple myeloma by Westhrin, Marita, Kovcic, Vlado, Zhang, Zejian, Moen, Siv H., Nedal, Tonje Marie Vikene, Bondt, Albert, Holst, Stephanie, Misund, Kristine, Buene, Glenn, Sundan, Anders, Waage, Anders, Slørdahl, Tobias S., Wuhrer, Manfred, Standal, Therese

“…Most patients with multiple myeloma develop a severe osteolytic bone disease. The myeloma cells secrete immunoglobulins, and the presence of monoclonal…”
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