Search Results - "Holst, L. B."

Red blood cell transfusion during septic shock in the ICU by PERNER, A., SMITH, S. H., CARLSEN, S., HOLST, L. B.

“…Background Transfusion of red blood cells (RBCs) remains controversial in patients with septic shock, but current practice is unknown. Our aim was to evaluate…”
Get full text

Association between fluid balance and mortality in patients with septic shock: a post hoc analysis of the TRISS trial by Cronhjort, M., Hjortrup, P. B., Holst, L. B., Joelsson-Alm, E., Mårtensson, J., Svensen, C., Perner, A.

“…Background Several studies have shown an association between a positive fluid balance and increased mortality in patients with septic shock. This may have led…”
Get full text

Development and internal validation of the Simplified Mortality Score for the Intensive Care Unit (SMS‐ICU) by Granholm, A., Perner, A., Krag, M., Hjortrup, P. B., Haase, N., Holst, L. B., Marker, S., Collet, M. O., Jensen, A. K. G., Møller, M. H.

“…Background Intensive care unit (ICU) mortality prediction scores deteriorate over time, and their complexity decreases clinical applicability and commonly…”
Get full text

Higher vs. lower haemoglobin threshold for transfusion in septic shock: subgroup analyses of the TRISS trial by Rygård, S. L., Holst, L. B., Wetterslev, J., Johansson, P. I., Perner, A.

“…Background Using a restrictive transfusion strategy appears to be safe in sepsis, but there may be subgroups of patients who benefit from transfusion at a…”
Get full text

Effects of simulated sample sizes on mortality estimates—Protocol for a study in 3 randomised ICU trials by Kofoed, A., Perner, A., Marker, S., Haase, N., Holst, L. B., Møller, M. H.

“…Background An increasing number of trials are stopped earlier than originally planned. It has been suggested that trials stopped pre‐maturely overestimate the…”
Get full text

Variability in targeted arterial oxygenation levels in patients with severe sepsis or septic shock by Dahl, R. M., Grønlykke, L., Haase, N., Holst, L. B., Perner, A., Wetterslev, J., Rasmussen, B. S., Meyhoff, C. S.

“…Background Supplemental oxygen therapy is used for intensive care (ICU) patients with severe sepsis, but with no general guidelines and few safety data. The…”
Get full text

Effects of red blood cell storage time on transfused patients in the ICU—protocol for a systematic review by Rygård, S. L., Jonsson, A. B., Madsen, M. B., Perner, A., Holst, L. B., Johansson, P. I., Wetterslev, J.

“…Background Patients in the intensive care unit (ICU) are often anaemic due to blood loss, impaired red blood cell (RBC) production and increased RBC…”
Get full text

Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis by Holst, Lars B, Petersen, Marie W, Haase, Nicolai, Perner, Anders, Wetterslev, Jørn

“…Objective To compare the benefit and harm of restrictive versus liberal transfusion strategies to guide red blood cell transfusions.Design Systematic review…”
Get full text

Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock by Holst, Lars B, Haase, Nicolai, Wetterslev, Jørn, Wernerman, Jan, Guttormsen, Anne B, Karlsson, Sari, Johansson, Pär I, Åneman, Anders, Vang, Marianne L, Winding, Robert, Nebrich, Lars, Nibro, Helle L, Rasmussen, Bodil S, Lauridsen, Johnny R.M, Nielsen, Jane S, Oldner, Anders, Pettilä, Ville, Cronhjort, Maria B, Andersen, Lasse H, Pedersen, Ulf G, Reiter, Nanna, Wiis, Jørgen, White, Jonathan O, Russell, Lene, Thornberg, Klaus J, Hjortrup, Peter B, Müller, Rasmus G, Møller, Morten H, Steensen, Morten, Tjäder, Inga, Kilsand, Kristina, Odeberg-Wernerman, Suzanne, Sjøbø, Brit, Bundgaard, Helle, Thyø, Maria A, Lodahl, David, Mærkedahl, Rikke, Albeck, Carsten, Illum, Dorte, Kruse, Mary, Winkel, Per, Perner, Anders

“…A large Scandinavian randomized trial showed no important outcome differences between hemoglobin levels of 7 g per deciliter and 9 g per deciliter as…”
Get full text

Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold: the TRISS randomised, multicentre clinical trial by Rygård, Sofie L., Holst, Lars B., Wetterslev, Jørn, Winkel, Per, Johansson, Pär I., Wernerman, Jan, Guttormsen, Anne B., Karlsson, Sari, Perner, Anders

“…Purpose We assessed the predefined long-term outcomes in patients randomised in the Transfusion Requirements in Septic Shock (TRISS) trial. Methods In 32…”
Get full text