Search Results - "Holskin, Beverly"

Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells by Wan, Weihua, Albom, Mark S., Lu, Lihui, Quail, Matthew R., Becknell, Nadine C., Weinberg, Linda R., Reddy, Dandu R., Holskin, Beverly P., Angeles, Thelma S., Underiner, Ted L., Meyer, Sheryl L., Hudkins, Robert L., Dorsey, Bruce D., Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng

“…The roles of aberrant expression of constitutively active ALK chimeric proteins in the pathogenesis of anaplastic large-cell lymphoma (ALCL) have been well…”
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ALK Mutants in the Kinase Domain Exhibit Altered Kinase Activity and Differential Sensitivity to Small Molecule ALK Inhibitors by Lu, Lihui, Ghose, Arup K, Quail, Matthew R, Albom, Mark S, Durkin, John T, Holskin, Beverly P, Angeles, Thelma S, Meyer, Sheryl L, Ruggeri, Bruce A, Cheng, Mangeng

“…Abnormal expression of constitutively active anaplastic lymphoma kinase (ALK) chimeric proteins in the pathogenesis of anaplastic large-cell lymphoma (ALCL) is…”
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Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models by Hudkins, Robert L, Diebold, James L, Tao, Ming, Josef, Kurt A, Park, Chung Ho, Angeles, Thelma S, Aimone, Lisa D, Husten, Jean, Ator, Mark A, Meyer, Sheryl L, Holskin, Beverly P, Durkin, John T, Fedorov, Alexander A, Fedorov, Elena V, Almo, Steven C, Mathiasen, Joanne R, Bozyczko-Coyne, Donna, Saporito, Michael S, Scott, Richard W, Mallamo, John P

“…The optimization of the dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-one R2 and R12 positions led to the identification of the first MLK1 and MLK3…”
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Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test by Tripathy, Rabindranath, McHugh, Robert J., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Huang, Zeck, Mathiasen, Joanne R., DiCamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Qian, Jie, Angeles, Thelma S., Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Duzic, Emir, Schaffhauser, Hervé, Rossé, Gerard C.

“…Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine6 (5-HT6) receptor…”
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Improvement of inhibitor identification for heat shock protein 90α by utilizing a red-shifted fluorescence polarization probe by Qian, Jie, Holskin, Beverly P, Theroff, Jay, Underiner, Ted, Meyer, Sheryl L, Angeles, Thelma S

“…Heat shock protein-90 (HSP90) is an ATP-dependent molecular chaperone with intrinsic ATPase activity. HSP90 is required for the stability and function of…”
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Comparison of two homogeneous cell-based kinase assays for JAK2 V617F: SureFire pSTAT5 and GeneBLAzer fluorescence resonance energy transfer assays by Qian, Jie, Mason, Jennifer L, Holskin, Beverly P, Murray, Kristen A, Meyer, Sheryl L, Ator, Mark A, Angeles, Thelma S

“…The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays an important role in cellular responses to cytokines and…”
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Modification of CellSensor irf1-bla TF-1 and irf1-bla HEL assays for direct comparison of wild-type JAK2 and JAK2 V617F inhibition by Mason, Jennifer L, Holskin, Beverly P, Murray, Kristen A, Meyer, Sheryl L, Wells-Knecht, Kevin J, Ator, Mark A, Angeles, Thelma S

“…The Janus kinase (JAK)-signal transducer and activator of transcription pathway is an important therapeutic target because of its role in the regulation of…”
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Inhibition of mixed lineage kinase 3 attenuates MPP +-induced neurotoxicity in SH-SY5Y cells by Mathiasen, Joanne R., McKenna, Beth Ann W., Saporito, Michael S., Ghadge, Ghanashyam D., Roos, Raymond P., Holskin, Beverly P., Wu, Zhi-Liang, Trusko, Stephen P., Connors, Thomas C., Maroney, Anna C., Thomas, Beth Ann, Thomas, Jeffrey C., Bozyczko-Coyne, Donna

“…The neuropathology of Parkinson's Disease has been modeled in experimental animals following MPTP treatment and in dopaminergic cells in culture treated with…”
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Phosphoregulation of Mixed-Lineage Kinase 1 Activity by Multiple Phosphorylation in the Activation Loop by Durkin, John T, Holskin, Beverly P, Kopec, Karla K, Reed, Matt S, Spais, Chrysanthe M, Steffy, Brian M, Gessner, George, Angeles, Thelma S, Pohl, Jan, Ator, Mark A, Meyer, Sheryl L

“…Mixed-lineage kinase 1 (MLK1) is a mitogen-activated protein kinase kinase kinase capable of activating the c-Jun NH2-terminal kinase (JNK) pathway…”
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Aequorin functional assay for characterization of G-protein-coupled receptors: Implementation with cryopreserved transiently transfected cells by Jones, Bruce, Holskin, Beverly, Meyer, Sheryl, Ung, Thao, Dupriez, Vincent, Flores, Sandra Y., Burgeon, Emmanuel, Ator, Mark, Duzic, Emir

“…Assay technologies that measure intracellular Ca 2+ release are among the predominant methods for evaluation of GPCR function. These measurements have…”
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Comparison of two homogeneous cell‐based kinase assays for JAK2 V617F: SureFire™ pSTAT5 and GeneBLAzer® FRET assays by Qian, Jie, Mason, Jennifer L., Holskin, Beverly P., Murray, Kristen A., Meyer, Sheryl L., Ator, Mark A., Angeles, Thelma S.

“…Abstract only The Janus kinase (JAK)/Signal Transducers and Activators of Transcription (STAT) signaling pathway plays an important role in cellular responses…”
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Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists by Sundar, Babu G., Bailey, Thomas R., Dunn, Derek D., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Zeqi, Huang, Mathiasen, Joanne R., Dicamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Brown, Rebecca, Qian, Jie, Angeles, Thelma, Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Galinis, Deborah, Duzic, Emir, Schaffhauser, Herve, Rosse, Gerard C.

“…h5-HT6R Ki=4.4nM; h5-HT6R cAMP IC50=9.8nM; estimated rat % F=36; brain/plasma: 2. 7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel…”
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Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF by Chen, Mann-Jy, Holskin, Beverly, Strickler, James, Gorniak, Joselina, Clark, Mike A, Johnson, Paul J, Mitcho, Michelle, Shalloway, David

“…Tumour necrosis factor alpha (ref. 1), synthesized primarily by monocytes in response to various invasive agents, induces a wide variety of biological effects…”
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