Search Results - "Holsapple, M."

A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins by Thomas, K., Aalbers, M., Bannon, G.A., Bartels, M., Dearman, R.J., Esdaile, D.J., Fu, T.J., Glatt, C.M., Hadfield, N., Hatzos, C., Hefle, S.L., Heylings, J.R., Goodman, R.E., Henry, B., Herouet, C., Holsapple, M., Ladics, G.S., Landry, T.D., MacIntosh, S.C., Rice, E.A., Privalle, L.S., Steiner, H.Y., Teshima, R., van Ree, R., Woolhiser, M., Zawodny, J.

“…Rationale. Evaluation of the potential allergenicity of proteins derived from genetically modified foods has involved a weight of evidence approach that…”
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Developmental immunotoxicity testing: a review by Holsapple, Michael P

“…There are currently no validated or widely accepted methods for evaluating the effects of a chemical on the developing immune system. Nonetheless because of…”
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Oral Bioaccessibility of Dioxins/Furans at Low Concentrations (50−350 ppt Toxicity Equivalent) in Soil by Ruby, M. V, Fehling, K. A, Paustenbach, D. J, Landenberger, B. D, Holsapple, M. P

“…Animal studies have indicated that the oral bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in environmentally contaminated soil could range from…”
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Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway by Sulentic, C E, Holsapple, M P, Kaminski, N E

“…The B-cell, a major cellular component of humoral immunity, has been identified as a sensitive target of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). The…”
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The Effects of Feed Restriction during in Utero and Postnatal Development in Rats by Carney, E. W., Zablotny, C. L., Marty, M. S., Crissman, J. W., Anderson, P., Woolhiser, M., Holsapple, M.

“…This study determined the effects of feed restriction (FR) during in utero and postnatal life on standard reproductive toxicity and developmental…”
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Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization by Plitnick, L.M., Loveless, S.E., Ladics, G.S., Holsapple, M.P., Smialowicz, R.J., Woolhiser, M.R., Anderson, P.K., Smith, C., Selgrade, M.J.K.

“…Isocyanates are low-molecular-weight chemicals implicated in allergic asthmatic-type reactions. Identification of chemicals likely to cause asthma is difficult…”
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Cytokine Profiling for Chemical Sensitizers: Application of the Ribonuclease Protection Assay and Effect of Dose by Plitnick, L.M., Loveless, S.E., Ladics, G.S., Holsapple, M.P., Selgrade, M.J., Sailstad, D.M., Smialowicz, R.J.

“…Exposure to chemicals in domestic and occupational settings may contribute to increases in asthma and allergy. Airway hypersensitivity (AHS) is T helper-2…”
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A Proposed Testing Framework for Developmental Immunotoxicology (DIT) by Holsapple, Michael P., Burns-Naas, Leigh Ann, Hastings, Kenneth L., Ladics, Gregory S., Lavin, Amy L., Makris, Susan L., Yang, Yung, Luster, Michael I.

“…A group of thirty immunotoxicology experts from the U.S. and E.U. representing government, industry, and academia met in May 2003, in Washington, D.C., to…”
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Influence of p53 zygosity on select sperm parameters of the mouse by Marty, M S, Singh, N P, Holsapple, M P, Gollapudi, B B

“…The influence of p53 gene zygosity on select parameters of mouse sperm was investigated by employing knock-out animal models. The background incidence of sperm…”
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Relevance and follow-up of positive results in in vitro genetic toxicity assays: An ILSI-HESI initiative by Thybaud, Véronique, Aardema, Marilyn, Casciano, Daniel, Dellarco, Vicki, Embry, Michelle R., Gollapudi, B. Bhaskar, Hayashi, Makoto, Holsapple, Michael P., Jacobson-Kram, David, Kasper, Peter, MacGregor, James T., Rees, Robert

“…In vitro genotoxicity assays are often used to screen and predict whether chemicals might represent mutagenic and carcinogenic risks for humans. Recent…”
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Symposium summary: Children's Health Risk—What's So Special about the Developing Immune System? by Holsapple, Michael P, Paustenbach, Dennis J, Charnley, Gail, West, Lori J, Luster, Michael I, Dietert, Rodney R, Burns-Naas, Leigh Ann

“…In recent years, there has been increasing regulatory pressure to protect the health of children, with the basic tenet being that children differ significantly…”
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A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update by Holsapple, M P, Snyder, N K, Wood, S C, Morris, D L

“…2,3,7,8-tetrachlorodibenzo-p-dioxin, more popularly called dioxin or TCDD and referred to in this review as 2,3,7,8-TCDD, is considered the prototype of the…”
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Developmental immunotoxicology and risk assessment: a workshop summary by Holsapple, M P

“…A workshop entitled 'Developmental Immunotoxicology and Risk Assessment' was held on 12-13 June 2001, in Washington, DC. The workshop was organized jointly by…”
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DEVELOPMENTAL IMMUNOTOXICOLOGY ASSESSMENT IN THE RAT: AGE, GENDER, AND STRAIN COMPARISONS AFTER EXPOSURE TO LEAD by Bunn, Terry L, Dietert, Rodney R., Ladics, Gregory S., Holsapple, Michael P.

“…A delayed-type hypersensitivity response (DTH) measured against keyhole limpet hemocyanin (KLH) and an enzyme-linked immunosorbant assay (ELISA) for anti-KLH…”
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Aryl hydrocarbon receptor-dependent suppression by 2,3,7, 8-tetrachlorodibenzo-p-dioxin of IgM secretion in activated B cells by Sulentic, C E, Holsapple, M P, Kaminski, N E

“…The immune system has been identified as a sensitive target for the toxic effects produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Furthermore, the B…”
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Molecular mechanisms of toxicant-induced immunosuppression: role of second messengers by Holsapple, M P, Karras, J G, Ledbetter, J A, Schieven, G L, Burchiel, S W, Davila, D R, Schatz, A R, Kaminski, N E

“…Changes in immunocompetence following chemical exposure have been established for a wide variety of unrelated agents. For the vast majority of immunotoxic…”
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Direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human tonsillar lymphocytes by Wood, S C, Jeong, H G, Morris, D L, Holsapple, M P

“…Murine lymphocyte function is quite sensitive to TCDD. However, in contrast to the murine model, the corresponding functional studies have not been undertaken…”
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Role of metabolism by esterase and cytochrome P-450 in cocaine-induced suppression of the antibody response by Jeong, T C, Jordan, S D, Matulka, R A, Stanulis, E D, Kaminski, E J, Holsapple, M P

“…To investigate the role of metabolism in cocaine-induced immunosuppression, diazinon and beta-ionone were administered as an esterase inhibitor and a…”
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CHARACTERIZATION OF AN APPROACH TO DEVELOPMENTAL IMMUNOTOXICOLOGY ASSESSMENT IN THE RAT USING SRBC AS THE ANTIGEN by Ladics, Gregory S., Smith, Charlene, Bunn, Terry L, Dietert, Rodney R., Anderson, Phyllis K., Wiescinski, Connie M., Holsapple, Michael P.

“…Although developmental immunotoxicology is an area of emerging importance, few data exist that compare profiles of activity in neonatal and adult rodents. One…”
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Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes by Williams, Courtney E., Crawford, Robert B., Holsapple, Michael P., Kaminski, Norbert E.

“…The objective of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and…”
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