Search Results - "Holroyd, Ailsa"

The role of mTOR-mediated signaling in the regulation of cellular migration by Holroyd, Ailsa K., Michie, Alison M.

“…•mTOR integrates mitogen and nutrient signals to regulate survival, proliferation and migration, processes commonly deregulated in cancer.•We summarize the…”
Get full text

AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival by Cosimo, Emilio, Tarafdar, Anuradha, Moles, Michael W, Holroyd, Ailsa K, Malik, Natasha, Catherwood, Mark A, Hay, Jodie, Dunn, Karen M, Macdonald, Alan M, Guichard, Sylvie M, O'Rourke, Declan, Leach, Michael T, Sansom, Owen J, Cosulich, Sabina C, McCaig, Alison M, Michie, Alison M

“…To determine whether inhibition of mTOR kinase-mediated signaling represents a valid therapeutic approach for chronic lymphocytic leukemia (CLL)…”
Get full text

PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling by Hay, Jodie, Tarafdar, Anuradha, Holroyd, Ailsa K, Moka, Hothri A, Dunn, Karen M, Alshayeb, Alzahra, Lloyd, Bryony H, Cassels, Jennifer, Malik, Natasha, Khan, Ashfia F, Sou, IengFong, Lees, Jamie, Almuhanna, Hassan N B, Kalakonda, Nagesh, Slupsky, Joseph R, Michie, Alison M

“…B cell antigen receptor (BCR) signalling competence is critical for the pathogenesis of chronic lymphocytic leukaemia (CLL). Defining key proteins that…”
Get full text

Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes by Nakagawa, Rinako, Vukovic, Milica, Tarafdar, Anuradha, Cosimo, Emilio, Dunn, Karen, McCaig, Alison M, Holroyd, Ailsa, McClanahan, Fabienne, Ramsay, Alan G, Gribben, John G, Michie, Alison M

“…Overwhelming evidence identifies the microenvironment as a critical factor in the development and progression of chronic lymphocytic leukemia, underlining the…”
Get full text

Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity by Hay, Jodie, Gilroy, Kathryn, Huser, Camille, Kilbey, Anna, Mcdonald, Alma, MacCallum, Amanda, Holroyd, Ailsa, Cameron, Ewan, Neil, James C.

“…MYC and RUNX oncogenes each trigger p53‐mediated failsafe responses when overexpressed in vitro and collaborate with p53 deficiency in vivo. However, together…”
Get full text

Elucidating the Role of mTor Kinase in Chronic Lymphocytic Leukaemia Cell Migration by Holroyd, Ailsa

“…Chronic lymphocytic leukaemia is a mature B cell neoplasm which, despite recent focused research attention, remains incurable. It is the commonest leukaemia in…”
Get full text

The ATP-Competitive mTOR Inhibitor AZD8055 Reduces Cell Proliferation and Tumour Load in Chronic Lymphocytic Leukaemia by Cosimo, Emilio, Tarafdar, Anuradha, Holroyd, Ailsa, Dunn, Karen, Catherwood, Mark, Michie, Alison M.

“…Chronic lymphocytic leukaemia (CLL), often diagnosed in the elderly, is incurable with current therapeutic regimes. Recent studies demonstrate that the…”
Get full text

Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning by Townsend, William M., Holroyd, Ailsa, Pearce, Rachel, Mackinnon, Stephen, Naik, Prakesh, Goldstone, Anthony H., Linch, David C., Peggs, Karl S., Thomson, Kirsty J., Singer, Mervyn, Howell, David C. J., Morris, Emma C.

“…Summary The use of allogeneic haematopoietic stem cell transplantation (Allo‐HSCT) is a standard treatment option for many patients with haematological…”
Get full text

A Simple Prognostic Score to Predict Short and Long-Term Survival Following ICU Admission in Critically Ill Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients: Improved Survival Following Reduced Intensity Conditioning by Townsend, William, Holroyd, Ailsa, Pearce, Rachel M, Mackinnon, Stephen, Goldstone, Anthony H., Linch, David C, Peggs, Karl S, Thomson, Kirsty, Singer, Mervyn, Naik, Prakesh, Howell, David, Morris, Emma

“…Abstract 146▪▪This icon denotes a clinically relevant abstract Transplant-related complications necessitate intensive care unit (ICU) admission in a…”
Get full text

The two faces of myeloproliferative neoplasms: Molecular events underlying lymphoid transformation by Holroyd, Ailsa, Cross, Nicholas C.P, Macdonald, Donald H

“…Abstract Multipotent haematopoietic stem cells pass through stages of differentiation with the progressive loss of developmental options leading to the…”
Get full text

Response to Tyrosine Kinase Inhibitor Therapy In Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation for Advanced Phase Chronic Myeloid Leukemia by Holroyd, Ailsa, Phillips, Elizabeth, Szydlo, Richard, Marin, David, Foroni, Letizia, Khorashad, Jamshid, Milojkovic, Dragana, Kanfer, Edward J., Dazzi, Francesco, MacDonald, Donald H., Rahemtulla, Amin, McLornan, Donal, Gabriel, Ian H, Pavlu, Jiri, Sargent, Jeremy, Goldman, John M., Apperley, Jane F., Rezvani, Katayoun

“…Abstract 3515 With the advent of tyrosine kinase inhibitors (TKI), allogeneic stem cell transplantation (allo-SCT) is largely reserved for patients with CML…”
Get full text