Search Results - "Holovati, Jelena L."

Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality by Almizraq, Ruqayyah, Tchir, Jayme D.R., Holovati, Jelena L., Acker, Jason P.

“…Background During storage detrimental biochemical and biomechanical changes occur within a red blood cell (RBC). RBC microparticles (RMPs) produced during…”
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Optimizing Access to Unrelated Donors in Canada: Re-Examining the Importance of Donor Factors on Outcomes Following Hematopoietic Cell Transplantation by Parmar, Gaganvir, Seftel, Matthew D, Ganz, Kathy, Blake, John, Holovati, Jelena L, Allan, David S

“…HLA-matched allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for many patients. Unrelated HLA-matched donors are the most frequently…”
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Synergistic effects of liposomes, trehalose, and hydroxyethyl starch for cryopreservation of human erythrocytes by Stoll, Christoph, Holovati, Jelena L., Acker, Jason P., Wolkers, Willem F.

“…Red blood cells (RBCs) can be cryopreserved using glycerol as a cryoprotective agent, but one of the main disadvantages is the time‐consuming deglycerolization…”
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Liposomes alter thermal phase behavior and composition of red blood cell membranes by Stoll, Christoph, Stadnick, Hart, Kollas, Oliver, Holovati, Jelena L., Glasmacher, Birgit, Acker, Jason P., Wolkers, Willem F.

“…Unilamellar liposomes composed of natural phospholipids provide a new promising class of protective agents for hypothermic storage, cryopreservation, or…”
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Cryopreserved amniotic membrane as transplant allograft: viability and post-transplant outcome by Perepelkin, Natasha M. J., Hayward, Kirsten, Mokoena, Tumelo, Bentley, Michael J., Ross-Rodriguez, Lisa U., Marquez-Curtis, Leah, McGann, Locksley E., Holovati, Jelena L., Elliott, Janet A. W.

“…Amniotic membrane (AM) transplantation is increasingly used in ophthalmological and dermatological surgeries to promote re-epithelialization and wound healing…”
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The effects of cryopreservation on red blood cell microvesiculation, phosphatidylserine externalization, and CD47 expression by Holovati, Jelena L., Wong, Kenneth A., Webster, Jarret M., Acker, Jason P.

“…BACKGROUND: Since the 1950s, cryopreservation has been used in transfusion medicine for long‐term storage of phenotypically rare red blood cells (RBCs). Recent…”
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Liposomes composed of unsaturated lipids for membrane modification of human erythrocytes by Stoll, Christoph, Holovati, Jelena L, Acker, Jason P, Wolkers, Willem F

“…Previous studies have shown that certain saturated lipids protect red blood cells (RBCs) during hypothermic storage but provide little protection during…”
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Automated closed volume reduction process for apheresis stem cell grafts: From development to clinical implementation by Howell, Anita, Letcher, Brenda, Murphy, Kelly, Elmoazzen, Heidi, Petraszko, Tanya, Acker, Jason P., Pineault, Nicolas, Holovati, Jelena L.

“…Background Collection of HPC by apheresis (HPC‐A) can sometimes result in higher collection volumes, increasing the dimethyl sulfoxide (DMSO) volume infused…”
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Phospholipidomics reveals differences in glycerophosphoserine profiles of hypothermically stored red blood cells and microvesicles by Bicalho, Beatriz, Holovati, Jelena L., Acker, Jason P.

“…During their normal in vivo life cycle erythrocytes (red blood cells, RBCs) undergo biochemical changes leading to membrane microvesiculation and shedding. RBC…”
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Characteristics of Extracellular Vesicles in Red Blood Concentrates Change with Storage Time and Blood Manufacturing Method by Almizraq, Ruqayyah J., Holovati, Jelena L., Acker, Jason P.

“…Background: Extracellular vesicles (EVs) in blood products are potential effectors of inflammation and coagulation after transfusion. The aim of this study was…”
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Extracellular Vesicle Characteristics in Stored Red Blood Cell Concentrates Are Influenced by the Method of Detection by Almizraq, Ruqayyah J, Seghatchian, Jerard, Holovati, Jelena L, Acker, Jason P

“…Abstract Extracellular vesicles (EVs), including microvesicles and exosomes, are small phospholipid vesicles (≤1 μm in diameter) that are present in blood…”
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Multicenter evaluation of the IL‐3‐pSTAT5 assay to assess the potency of cryopreserved stem cells from cord blood units: The BEST Collaborative study by Trépanier, Patrick, Fournier, Diane, Simard, Carl, Fontaine, Magali J., Stroncek, David, Takanashi, Minoko, McKenna, David, Schwartz, Joseph, Tanhehco, Yvette C., Reems, Jo‐Anna, Torrents, Silvia, Kogler, Gesine, Liedtke, Stefanie, Giroux, Martin, Holovati, Jelena L., Louis, Isabelle, Prasath, Arun, Pineault, Nicolas, Bazin, Renée

“…Background The IL‐3‐pSTAT5 assay, a new, rapid, and standardized flow‐cytometry‐based assay may compensate for several limitations of the colony‐forming unit…”
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Cord blood clinical processing, cryopreservation, and storage by Elmoazzen, Heidi, Holovati, Jelena L

“…Allogeneic umbilical cord blood (UCB) hematopoietic stem cell transplantation has become a crucial advancement in the treatment for a variety of diseases…”
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Differences in Rat and Human Erythrocytes Following Blood Component Manufacturing: The Effect of Additive Solutions by da SilveiraCavalcante, Luciana, Acker, Jason P., Holovati, Jelena L.

“…Background: Small animal models have been previously used in transfusion medicine studies to evaluate the safety of blood transfusion products. Although there…”
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Evaluation of the functional properties of cryopreserved buffy coat–derived monocytes for monocyte monolayer assay by Kipkeu, Betty J., Shyian, Melissa L., da Silveira Cavalcante, Luciana, Duong, Trang T., Yeung, Rae S.M., Binnington, Beth, Branch, Donald R., Acker, Jason P., Holovati, Jelena L.

“…BACKGROUND Monocyte monolayer assay (MMA) is a compatibility testing method for evaluating the clinical significance of red blood cell (RBC) alloantibodies…”
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Rejuvenation of ATP during storage does not reverse effects of the hypothermic storage lesion by Tchir, Jayme D.R., Acker, Jason P., Holovati, Jelena L.

“…Background Hypothermic storage (HS) of red blood cells (RBCs) leads to a progressive deterioration of cell quality. Mitigating these deleterious changes could…”
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Effect of liposome-treated red blood cells in an anemic rat model by da Silveira Cavalcante, Luciana, Feng, Qingping, Chin-Yee, Ian, Acker, Jason P., Holovati, Jelena L.

“…Context: Liposomes have been shown to improve human red blood cell (RBC) in vitro quality by minimizing membrane damage occurring during 42-d hypothermic…”
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The effects of rejuvenation during hypothermic storage on red blood cell membrane remodeling by Kurach, Jayme D.R., Almizraq, Ruqayyah, Bicalho, Beatriz, Acker, Jason P., Holovati, Jelena L.

“…Background Our previous studies showed that hypothermic storage (HS) induces red blood cell (RBC) microparticle (RMP) generation and changes in…”
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112 Membrane changes in liposome-treated rat red blood cells upon hypothermic storage by Silveira Cavalcante, Luciana da, Acker, Jason P., Holovati, Jelena L.

“…Liposomes, which are microscopic synthetic lipid vesicles, have been shown to improve red blood cell (RBC) in vitro quality by minimizing membrane damage…”
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The immune-stimulation capacity of liposome-treated red blood cells by da Silveira Cavalcante, Luciana, Branch, Donald R., Duong, Trang T., Yeung, Rae S.M., Acker, Jason P., Holovati, Jelena L.

“…Our in vivo studies on a rat model established safety of transfusing liposome-treated red blood cells (RBCs) but identified the potential for immune modulation…”
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