Search Results - "Holopainen, Irma E."

Seizures in the developing brain: Cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization by Holopainen, Irma E.

“…Epilepsy is a common neurological disorder that occurs more frequently in children than in adults. The extent that prolonged seizure activity, i.e. status…”
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Organotypic hippocampal slice cultures: a model system to study basic cellular and molecular mechanisms of neuronal cell death, neuroprotection, and synaptic plasticity by Holopainen, Irma E

“…The hippocampus has become one of the most extensively studied areas of the mammalian brain, and its proper function is of utmost importance, particularly for…”
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Transcriptome analysis of the hippocampal CA1 pyramidal cell region after kainic acid-induced status epilepticus in juvenile rats by Laurén, Hanna B, Lopez-Picon, Francisco R, Brandt, Annika M, Rios-Rojas, Clarissa J, Holopainen, Irma E

“…Molecular mechanisms involved in epileptogenesis in the developing brain remain poorly understood. The gene array approach could reveal some of the factors…”
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Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus by Järvelä, Juha T, Lopez-Picon, Francisco R, Plysjuk, Anna, Ruohonen, Saku, Holopainen, Irma E

“…Status epilepticus (SE) is proposed to lead to an age-dependent acute activation of a repertoire of inflammatory processes, which may contribute to neuronal…”
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Changes in microtubule‐associated protein‐2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus by Jalava, Niina S., Lopez‐Picon, Francisco R., Kukko‐Lukjanov, Tiina‐Kaisa, Holopainen, Irma E.

“…In this study, we analyzed the spatiotemporal expression patterns of the high‐molecular weight (MAP2a and b) and low‐molecular weight (MAP2c and d)…”
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Resistance of neurofilaments to degradation, and lack of neuronal death and mossy fiber sprouting after kainic acid-induced status epilepticus in the developing rat hippocampus by Lopez-Picon, Francisco, Puustinen, Niina, Kukko-Lukjanov, Tiina-Kaisa, Holopainen, Irma E.

“…Neurofilament (NF) proteins, the major constituent of intermediate filaments in neurons, have an important role in cellular stability and plasticity. We have…”
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Quantitative 1HMRS and MRI Volumetry Indicate Neuronal Damage in the Hippocampus of Children with Focal Epilepsy and Infrequent Seizures by Varho, Tarja, Komu, Markku, Sonninen, Pirkko, Lähdetie, Jaana, Holopainen, Irma E.

“…Purpose: Seizures induce progressive morphologic and functional changes in particular in the hippocampus, but whether and at what stage the hippocampus is…”
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Glutamate signaling in the pathophysiology and therapy of prenatal insults by Holopainen, Irma E., Laurén, Hanna B.

“…Birth asphyxia and hypoxia-ischemia (HI) are important factors affecting the normal development and maturation of the central nervous system (CNS). Depending…”
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Maturation of cultured hippocampal slices results in increased excitability in granule cells by Lindroos, Markus M., Soini, Sanna L., Kukko‐Lukjanov, Tiina‐Kaisa, Korpi, Esa R., Lovinger, David, Holopainen, Irma E.

“…The preparation of hippocampal slices results in loss of input neurons to dentate granule cells, which leads to the reorganization of their axons, the mossy…”
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Histamine 1 receptor knock out mice show age-dependent susceptibility to status epilepticus and consequent neuronal damage by Kukko-Lukjanov, Tiina-Kaisa, Grönman, Maria, Lintunen, Minnamaija, Laurén, Hanna B, Michelsen, Kimmo A, Panula, Pertti, Holopainen, Irma E

“…Summary The central histaminergic neuron system is an important regulator of activity stages such as arousal and sleep. In several epilepsy models, histamine…”
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Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death by Järvelä, Juha T., Ruohonen, Saku, Kukko-Lukjanov, Tiina-Kaisa, Plysjuk, Anna, Lopez-Picon, Francisco R., Holopainen, Irma E.

“…In the postnatal rodent hippocampus status epilepticus (SE) leads to age- and region-specific excitotoxic neuronal damage, the precise mechanisms of which are…”
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Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice by Kukko-Lukjanov, Tiina-Kaisa, Lintunen, Minnamaija, Jalava, Niina, Laurén, Hanna B, Lopez-Picon, Francisco R, Michelsen, Kimmo A, Panula, Pertti, Holopainen, Irma E

“…Summary The central histaminergic neuronal system is a powerful modulator of brain activity, and its functional disturbance is related to e.g. epilepsy. We…”
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Histaminergic Neurons Protect the Developing Hippocampus from Kainic Acid-Induced Neuronal Damage in an Organotypic Coculture System by Kukko-Lukjanov, Tiina-Kaisa, Soini, Sanna, Taira, Tomi, Michelsen, Kimmo A, Panula, Pertti, Holopainen, Irma E

“…The central histaminergic neuron system inhibits epileptic seizures, which is suggested to occur mainly through histamine 1 (H1) and histamine 3 (H3)…”
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Age‐dependent cyclooxygenase‐2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus by Järvelä, Juha T., Lopez‐Picon, Francisco R., Holopainen, Irma E.

“…Summary Purpose: Epileptic seizures lead to age‐dependent neuronal damage in the developing brain, particularly in the hippocampus, but the mechanisms involved…”
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Quantitative HMRS and MRI volumetry indicate neuronal damage in the hippocampus of children with focal epilepsy and infrequent seizures by Varho, Tarja, Komu, Markku, Sonninen, Pirkko, Lähdetie, Jaana, Holopainen, Irma E

“…Seizures induce progressive morphologic and functional changes in particular in the hippocampus, but whether and at what stage the hippocampus is affected in…”
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Brain oscillatory EEG event-related desynchronization (ERD) and -sychronization (ERS) responses during an auditory memory task are altered in children with epilepsy by Krause, Christina M, Boman, Petra-Ann, Sillanmäki, Lauri, Varho, Tarja, Holopainen, Irma E

“…Summary Purpose Children with epilepsy are in risk for cognitive impairment, but reliable methods, other than neuropsychological testing, to verify such a…”
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Auditory event related potentials as tools to reveal cognitive late effects in childhood cancer patients by Järvelä, Liisa S, Hurme, Saija, Holopainen, Irma E, Leino, Maria, Hatanpää, Anne-Mari, Mikola, Hannu, Kärki, Tarmo, Salmi, Toivo T, Lähteenmäki, Päivi M

“…Abstract Objective The purpose of this study was to analyze event related potentials mismatch negativity (MMN) and P3a in childhood cancer patients at the time…”
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The calpain inhibitor MDL-28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid-treated hippocampal slice cultures by Lopez-Picon, Francisco R., Kukko-Lukjanov, Tiina-Kaisa, Holopainen, Irma E.

“…The cytoskeleton controls the architecture and survival of the central nervous system neurons by maintaining the stability of axons, dendrites and cellular…”
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AMPA/kainate receptor-mediated up-regulation of GABAA receptor δ subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation by SALONEN, Virpi, KALLINEN, Sampsa, LOPEZ-PICON, Francisco R, KORPI, Esa R, HOLOPAINEN, Irma E, UUSI-OUKARI, Mikko

“…We have studied the effects of AMPA/kainate receptor agonists on GABA(A) receptor subunit mRNA expression in vitro in cultured rat cerebellar granule cells…”
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Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets by Aaltonen, Minna, Soukka, Hanna, Halkola, Lauri, Jalonen, Jarmo, Kalimo, Hannu, Holopainen, Irma E, Kääpä, Pekka O

“…Abstract Background Meconium aspiration-induced hypertensive lung injury is frequently associated with neuronal damage. Inhaled nitric oxide (iNO) is widely…”
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