Search Results - "Holmstrøm, Morten"

Differential Dynamics of CALR Mutant Allele Burden in Myeloproliferative Neoplasms during Interferon Alfa Treatment by Kjær, Lasse, Cordua, Sabrina, Holmström, Morten O, Thomassen, Mads, Kruse, Torben A, Pallisgaard, Niels, Larsen, Thomas S, de Stricker, Karin, Skov, Vibe, Hasselbalch, Hans C

“…Discovery of somatic mutations in the calreticulin gene (CALR) has identified a subgroup of Philadelphia-negative chronic myeloproliferative neoplasms (MPN)…”
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A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma by Kjeldsen, Julie Westerlin, Lorentzen, Cathrine Lund, Martinenaite, Evelina, Ellebaek, Eva, Donia, Marco, Holmstroem, Rikke Boedker, Klausen, Tobias Wirenfeldt, Madsen, Cecilie Oelvang, Ahmed, Shamaila Munir, Weis-Banke, Stine Emilie, Holmström, Morten Orebo, Hendel, Helle Westergren, Ehrnrooth, Eva, Zocca, Mai-Britt, Pedersen, Ayako Wakatsuki, Andersen, Mads Hald, Svane, Inge Marie

“…Anti-programmed death (PD)-1 (aPD1) therapy is an effective treatment for metastatic melanoma (MM); however, over 50% of patients progress due to resistance…”
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Cancer immune therapy for myeloid malignancies: present and future by Holmström, Morten Orebo, Hasselbalch, Hans Carl

“…The myelodysplastic syndromes, the chronic myeloproliferative neoplasms, and the acute myeloid leukemia are malignancies of the myeloid hematopoietic stem…”
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The Danish National Multiple Myeloma Registry by Gimsing, Peter, Holmström, Morten O, Klausen, Tobias Wirenfelt, Andersen, Niels Frost, Gregersen, Henrik, Pedersen, Robert Schou, Plesner, Torben, Pedersen, Per Trøllund, Frederiksen, Mikael, Frølund, Ulf, Helleberg, Carsten, Vangsted, Annette, de Nully Brown, Peter, Abildgaard, Niels

“…The Danish National Multiple Myeloma Registry (DMMR) is a population-based clinical quality database established in January 2005. The primary aim of the…”
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Cancer Immune Therapy for Philadelphia Chromosome-Negative Chronic Myeloproliferative Neoplasms by Holmström, Morten Orebo, Hasselbalch, Hans Carl, Andersen, Mads Hald

“…Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPN) are neoplastic diseases of the hematopoietic stem cells in the bone marrow. MPN are…”
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Causes of early death in multiple myeloma patients who are ineligible for high‐dose therapy with hematopoietic stem cell support: A study based on the nationwide Danish Myeloma Database by Holmström, Morten O., Gimsing, Peter, Abildgaard, Niels, Andersen, Niels F., Helleberg, Carsten, Clausen, Niels Aage T., Klausen, Tobias W., Frederiksen, Mikael, Kristensen, Dan L., Larsen, Herdis, Pedersen, Per T., Andersen, Kristian Thidemann, Pedersen, Robert Schou, Jensen, Bo Amdi, Gregersen, Henrik, Vangsted, Annette J.

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Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine by Gigoux, Mathieu, Holmström, Morten O, Zappasodi, Roberta, Park, Joseph J, Pourpe, Stephane, Bozkus, Cansu Cimen, Mangarin, Levi M B, Redmond, David, Verma, Svena, Schad, Sara, George, Mariam M, Venkatesh, Divya, Ghosh, Arnab, Hoyos, David, Molvi, Zaki, Kamaz, Baransel, Marneth, Anna E, Duke, William, Leventhal, Matthew J, Jan, Max, Ho, Vincent T, Hobbs, Gabriela S, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Lindsley, R Coleman, Hasselbalch, Hans, Grauslund, Jacob H, Lisle, Thomas L, Met, Özcan, Wilkinson, Patrick, Greenbaum, Benjamin, Sepulveda, Manuel A, Chan, Timothy, Rampal, Raajit, Andersen, Mads H, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd D, Mullally, Ann, Merghoub, Taha

“…The majority of JAK2 -negative myeloproliferative neoplasms (MPNs) have disease-initiating frameshift mutations in calreticulin ( ), resulting in a common…”
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Characterization of TGFβ-specific CD4+T cells through the modulation of TGFβ expression in malignant myeloid cells by Mortensen, Rasmus Erik Johansson, Holmström, Morten Orebo, Andersen, Mads Hald

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The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets by Holmström, Morten Orebo, Ruders, Josephine Hallundbæk, Riley, Caroline Hasselbalch, Larsen, Morten Kranker, Grauslund, Jacob Handlos, Kjær, Lasse, Skov, Vibe, Ellervik, Christina, Guo, Belinda B, Linden, Matthew, Hasselbalch, Hans Carl, Andersen, Mads Hald

“…Recently, an antibody which inhibits the glycoprotein A repetitions predominant (GARP)-mediated release of active transforming growth factor beta (TGFβ) from…”
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Healthy Donors Harbor Memory T Cell Responses to RAS Neo-Antigens by Holmström, Morten Orebo, Andersen, Mads Hald

“…The RAS mutations are the most frequently occurring somatic mutations in humans, and several studies have established that T cells from patients with…”
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Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes by Kjaer, Lasse, Holmström, Morten O., Cordua, Sabrina, Andersen, Mads Hald, Svane, Inge Marie, Thomassen, Mads, Kruse, Torben A, Pallisgaard, Niels, Skov, Vibe, Hasselbalch, Hans C.

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Production and Characterization of Peptide Antibodies to the C-Terminal of Frameshifted Calreticulin Associated with Myeloproliferative Diseases by Mughal, Farah Perveen, Bergmann, Ann Christina, Huynh, Ha Uyen Buu, Jørgensen, Sarah Hyllekvist, Mansha, Inaam, Kesmez, Meliha, Schürch, Patrick Mark, Theocharides, Alexandre Pierre André, Hansen, Paul Robert, Friis, Tina, Holmström, Morten Orebo, Ciplys, Evaldas, Slibinskas, Rimantas, Højrup, Peter, Houen, Gunnar, Trier, Nicole Hartwig

“…Myeloproliferative Neoplasms (MPNs) constitute a group of rare blood cancers that are characterized by mutations in bone marrow stem cells leading to the…”
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Impact of peptide:HLA complex stability for the identification of SARS-CoV-2-specific CD8 + T cells by Lie-Andersen, Olivia, Hübbe, Mie Linder, Subramaniam, Krishanthi, Steen-Jensen, Daniel, Bergmann, Ann Christina, Justesen, Daniel, Holmström, Morten Orebo, Turtle, Lance, Justesen, Sune, Lança, Telma, Hansen, Morten

“…Induction of a lasting protective immune response is dependent on presentation of epitopes to patrolling T cells through the HLA complex. While peptide:HLA…”
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JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation by Czech, Julia, Cordua, Sabrina, Weinbergerova, Barbora, Baumeister, Julian, Crepcia, Assja, Han, Lijuan, Maié, Tiago, Costa, Ivan G., Denecke, Bernd, Maurer, Angela, Schubert, Claudia, Feldberg, Kristina, Gezer, Deniz, Brümmendorf, Tim H., Müller-Newen, Gerhard, Mayer, Jiri, Racil, Zdenek, Kubesova, Blanka, Knudsen, Trine, Sørensen, Anders L., Holmström, Morten, Kjær, Lasse, Skov, Vibe, Larsen, Thomas Stauffer, Hasselbalch, Hans C., Chatain, Nicolas, Koschmieder, Steffen

“…Pegylated interferon-α (peg-IFNa) treatment induces molecular responses (MR) in patients with myeloproliferative neoplasms (MPNs), including partial MR (PMR)…”
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Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow by Holmström, Morten Orebo, Andersen, Morten, Traynor, Sofie, Ahmad, Shamaila Munir, Lisle, Thomas Landkildehus, Handlos Grauslund, Jacob, Skov, Vibe, Kjær, Lasse, Ottesen, Johnny T., Gjerstorff, Morten Frier, Hasselbalch, Hans Carl, Andersen, Mads Hald

“…BackgroundTherapeutic cancer vaccination against mutant calreticulin (CALR) in patients with CALR-mutant (CALRmut) myeloproliferative neoplasms (MPN) induces…”
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Evidence of immune elimination, immuno-editing and immune escape in patients with hematological cancer by Holmström, Morten Orebo, Cordua, Sabrina, Skov, Vibe, Kjær, Lasse, Pallisgaard, Niels, Ellervik, Christina, Hasselbalch, Hans Carl, Andersen, Mads Hald

“…There is mounting evidence that the immune system can spontaneously clear malignant lesions before they manifest as overt cancer, albeit this activity has been…”
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Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR -Mutant Chronic Myeloproliferative Neoplasms by Handlos Grauslund, Jacob, Holmström, Morten Orebo, Jørgensen, Nicolai Grønne, Klausen, Uffe, Weis-Banke, Stine Emilie, El Fassi, Daniel, Schöllkopf, Claudia, Clausen, Mette Borg, Gjerdrum, Lise Mette Rahbek, Breinholt, Marie Fredslund, Kjeldsen, Julie Westerlin, Hansen, Morten, Koschmieder, Steffen, Chatain, Nicolas, Novotny, Guy Wayne, Petersen, Jesper, Kjær, Lasse, Skov, Vibe, Met, Özcan, Svane, Inge Marie, Hasselbalch, Hans Carl, Andersen, Mads Hald

“…The calreticulin ( ) exon 9 mutations that are identified in 20% of patients with Philadelphia chromosome negative chronic myeloproliferative neoplasms (MPN)…”
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An arginase1- and PD-L1-derived peptide-based vaccine for myeloproliferative neoplasms: A first-in-man clinical trial by Grauslund, Jacob Handlos, Holmström, Morten Orebo, Martinenaite, Evelina, Lisle, Thomas Landkildehus, Glöckner, Hannah Jorinde, El Fassi, Daniel, Klausen, Uffe, Mortensen, Rasmus E J, Jørgensen, Nicolai, Kjær, Lasse, Skov, Vibe, Svane, Inge Marie, Hasselbalch, Hans Carl, Andersen, Mads Hald

“…Arginase-1 (ARG1) and Programed death ligand-1 (PD-L1) play a vital role in immunosuppression in myeloproliferative neoplasms (MPNs) and directly inhibit…”
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The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy by Ahmad, Shamaila Munir, Martinenaite, Evelina, Holmström, Morten, Jørgensen, Mia Aaboe, Met, Özcan, Nastasi, Claudia, Klausen, Uffe, Donia, Marco, Pedersen, Lars Møller, Munksgaard, Lars, Ødum, Niels, Woetmann, Anders, Svane, Inge Marie, Andersen, Mads Hald

“…Cell surface molecules of the B7/CD28 family play an important role in T-cell activation and tolerance. The relevance of the PD-1/PD-L1 pathway in cancer has…”
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Case Report: First longitudinal study of a patient with CALR positive clonal hematopoiesis of indeterminate potential developing into pre-fibrotic myelofibrosis by Kjær, Lasse, Skov, Vibe, Larsen, Morten Kranker, Boklund, Tobias Idor, Andersen, Morten, Kefala, Maria, Knudsen, Trine A, Schjellerup Eickhardt-Dalbøge, Christina, Stiehl, Thomas, Gudmand-Høyer, Johanne, Snyder, Jordan, Holmström, Morten, Andersen, Mads H, Ottesen, Johnny T, Ellervik, Christina, Hasselbalch, Hans C

“…Initial diagnosis of overt myeloproliferative neoplasms (MPNs) represents the juncture during clonal evolution when symptoms or complications prompt an…”
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