Search Results - "Holmquist, Christopher R"

Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: An agonist probe for the α7 nicotinic acetylcholine receptor by Ravert, Hayden T., Dorff, Peter, Foss, Catherine A., Mease, Ronnie C., Fan, Hong, Holmquist, Christopher R., Phillips, Eifion, McCarthy, Dennis J., Heys, J. Richard, Holt, Daniel P., Wang, Yuchuan, Endres, Christopher J., Dannals, Robert F., Pomper, Martin G.

“…The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is key in brain communication and has been implicated in the pathophysiology of diseases of the central…”
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Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1 by Varnes, Jeffrey G., Xiong, Hui, Forst, Janet M., Holmquist, Christopher R., Ernst, Glen E., Frietze, William, Dembofsky, Bruce, Andisik, Don W., Palmer, William E., Hinkley, Lindsay, Steelman, Gary B., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Potts, William M., Wang, Xia, Brugel, Todd A., Alhambra, Cristóbal, Wood, Michael W., Veale, Chris A., Albert, Jeffrey S.

“…A series of isoquinuclidines and bicyclic analogs were investigated as inhibitors of glycine uptake for the treatment of schizophrenia. Dimethylbenzamide 9…”
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Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors by Varnes, Jeffrey G., Geschwindner, Stefan, Holmquist, Christopher R., Forst, Janet, Wang, Xia, Dekker, Niek, Scott, Clay W., Tian, Gaochao, Wood, Michael W., Albert, Jeffrey S.

“…[Display omitted] Fragment-based drug design (FBDD) relies on direct elaboration of fragment hits and typically requires high resolution structural information…”
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Radiochemical synthesis and in vivo evaluation of [ super(18)F]AZ11637326: An agonist probe for the alpha 7 nicotinic acetylcholine receptor by Ravert, H T, Dorff, P, Foss, CA, Mease, R C, Fan, H, Holmquist, C R, Phillips, E, McCarthy, D J, Heys, J R, Holt, D P, Wang, Y, Endres, C J, Dannals, R F, Pomper, M G

“…Introduction: The alpha-7 nicotinic acetylcholine receptor ( alpha 7 nAChR) is key in brain communication and has been implicated in the pathophysiology of…”
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Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1 by Varnes, Jeffrey G., Forst, Janet M., Hoerter, Tiffany N., Holmquist, Christopher R., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Wang, Xia, Potts, William M., Wood, Michael W., Alhambra, Cristóbal, Brugel, Todd A., Albert, Jeffrey S.

“…A series of novel GlyT1 inhibitors is described. A novel series of glycine transporter 1 (GlyT1) inhibitors is described. Scoping of the heterocycle moiety of…”
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Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-lipoxin A4 by Phillips, Eifion D, Chang, Hui-Fang, Holmquist, Christopher R, McCauley, John P

“…We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, a compound…”
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A selective method for the direct conversion of aldehydes into .beta.-keto esters with ethyl diazoacetate catalyzed by tin(II) chloride by Holmquist, Christopher R, Roskamp, Eric J

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3α-(4-Substituted phenyl)nortropane-2β-carboxylic acid methyl esters show selective binding at the norepinephrine transporter by Blough, Bruce E, Holmquist, Christopher R, Abraham, Philip, Kuhar, Michael J, Carroll, F.Ivy

“…A series of 3α-(4-substituted)nortropane-2β-carboxylic acid methyl esters was synthesized and evaluated for the ability to inhibit radioligand binding at the…”
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3α-(4‘-Substituted phenyl)tropane- 2β-carboxylic Acid Methyl Esters:  Novel Ligands with High Affinity and Selectivity at the Dopamine Transporter by Holmquist, Christopher R, Keverline-Frantz, Kathryn I, Abraham, Philip, Boja, John W, Kuhar, Michael J, Carroll, F. Ivy

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Rhodium-Catalyzed Alkyne Cyclotrimerization Strategies for C-Aryl Glycoside Synthesis by McDonald, Frank E, Zhu, Hugh Y. H, Holmquist, Christopher R

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β[beta]-keto esters from tin(II) chloride catalyzed reactions of aldehydes with ethyl diazoacetate: An undergraduate laboratory experiment drawn from the current literature by Brockwell, Joyce C, Holmquist, Christopher R

“…This is an experimental procedure for producing longer-chain keto esters from unconjugated aldehydes on reaction with ethyl diazoacetate catalyzed by Lewis…”
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Radiochemical synthesis and in vivo e valuation of [18 F]AZ11637326: An agonist probe for the α7 nicotinic acetylcholine receptor by Ravert, Hayden T, Dorff, Peter, Foss, Catherine A, Mease, Ronnie C, Fan, Hong, Holmquist, Christopher R, Phillips, Eifion, McCarthy, Dennis J, Heys, J. Richard, Holt, Daniel P, Wang, Yuchuan, Endres, Christopher J, Dannals, Robert F, Pomper, Martin G

“…Abstract Introduction The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is key in brain communication and has been implicated in the pathophysiology of…”
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Synthesis of methyl (5S, 6R, 7E, 9E, 11Z, 13E, 15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexad ecatetraenoate, an analogue of 15R-lipoxin A4 by PHILLIPS, Eifion D, CHANG, Hui-Fang, HOLMQUIST, Christopher R, MCCAULEY, John P

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Synthesis of methyl (5 S,6 R,7 E,9 E,11 Z,13 E,15 S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15 R-Lipoxin A 4 by Phillips, Eifion D, Chang, Hui-Fang, Holmquist, Christopher R, McCauley, John P

“…We describe a method for the synthesis of methyl (5 S,6 R,7 E,9 E,11 Z,13 E,15 S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, a…”
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(Beta)-Keto Esters from Tin(II) Chloride Catalyzed Reactions of Aldehydes with Ethyl Diazoacetate by Brockwell, Joyce C, Holmquist, Christopher R

“…An experiment demonstrating that beta-keto ester structure is a useful substrate for synthesis is presented. The experiment is easily carried out within two…”
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RTI-352: A 3? analogue of RTI-55 as an in vivo dopamine transporter binding ligand by Zhan, Yougen, Saindane, Amit M., Scheffel, Ursula, Carroll, F. Ivy, Holmquist, Christopher R., Kepler, John A., Taylor, George F., Kuhar, Michael J.

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RTI-352: A 3α analogue of RTI-55 as an in vivo dopamine transporter binding ligand by Zhan, Yougen, Saindane, Amit M., Scheffel, Ursula, Carroll, F. Ivy, Holmquist, Christopher R., Kepler, John A., Taylor, George F., Kuhar, Michael J.

“…The 3 beta (substituted phenyl)tropane-2 beta -carboxylic acid esters are effective in vivo binding ligands for dopamine transporters (DATs). We have recently…”
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