Search Results - "Holmes, V"

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation by Richardson, Tom G, Leyden, Genevieve M, Wang, Qin, Bell, Joshua A, Elsworth, Benjamin, Davey Smith, George, Holmes, Michael V

“…Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets…”
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Mendelian randomization in cardiometabolic disease: challenges in evaluating causality by Holmes, Michael V., Ala-Korpela, Mika, Smith, George Davey

“…Key Points Mendelian randomization (MR) is a powerful tool that utilizes genetic information to inform about the likely causal relevance of an exposure to an…”
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Obesity and risk of female reproductive conditions: A Mendelian randomisation study by Venkatesh, Samvida S, Ferreira, Teresa, Benonisdottir, Stefania, Rahmioglu, Nilufer, Becker, Christian M, Granne, Ingrid, Zondervan, Krina T, Holmes, Michael V, Lindgren, Cecilia M, Wittemans, Laura B L

“…Obesity is observationally associated with altered risk of many female reproductive conditions. These include polycystic ovary syndrome (PCOS), abnormal…”
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Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation by Wang, Qin, Holmes, Michael V, Davey Smith, George, Ala-Korpela, Mika

“…Insulin resistance has deleterious effects on cardiometabolic disease. We used Mendelian randomization analyses to clarify the causal relationships of insulin…”
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Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation by Qian, Zhaohui, Dominguez, Samuel R, Holmes, Kathryn V

“…Little is known about the biology of the emerging human group c betacoronavirus, Middle East Respiratory Syndrome coronavirus (MERS-CoV). Because coronavirus…”
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Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis by Richardson, Tom G, Sanderson, Eleanor, Palmer, Tom M, Ala-Korpela, Mika, Ference, Brian A, Davey Smith, George, Holmes, Michael V

“…Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for…”
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Mendel’s laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues by Davey Smith, George, Holmes, Michael V., Davies, Neil M., Ebrahim, Shah

“…We respond to criticisms of Mendelian randomization (MR) by Mukamal, Stampfer and Rimm (MSR). MSR consider that MR is receiving too much attention and should…”
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GWAS identifies 14 loci for device-measured physical activity and sleep duration by Doherty, Aiden, Smith-Byrne, Karl, Ferreira, Teresa, Holmes, Michael V., Holmes, Chris, Pulit, Sara L., Lindgren, Cecilia M.

“…Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on…”
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Causal relationships between obesity and the leading causes of death in women and men by Censin, Jenny C, Peters, Sanne A E, Bovijn, Jonas, Ferreira, Teresa, Pulit, Sara L, Mägi, Reedik, Mahajan, Anubha, Holmes, Michael V, Lindgren, Cecilia M

“…Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains unclear whether there are similar causal effects of obesity traits on…”
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The impact of body mass index on maternal and neonatal outcomes: a retrospective study in a UK obstetric population, 2004–2011 by Scott‐Pillai, R, Spence, D, Cardwell, CR, Hunter, A, Holmes, VA

“…Objective To assess the prevalence of overweight and obesity, and the impact of body mass index (BMI) on maternal and neonatal outcomes, in a UK obstetric…”
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Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China by Bragg, Fiona, Holmes, Michael V, Iona, Andri, Guo, Yu, Du, Huaidong, Chen, Yiping, Bian, Zheng, Yang, Ling, Herrington, William, Bennett, Derrick, Turnbull, Iain, Liu, Yongmei, Feng, Shixian, Chen, Junshi, Clarke, Robert, Collins, Rory, Peto, Richard, Li, Liming, Chen, Zhengming

“…IMPORTANCE: In China, diabetes prevalence has increased substantially in recent decades, but there are no reliable estimates of the excess mortality currently…”
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Guidelines for performing Mendelian randomization investigations by Burgess, Stephen, Davey Smith, George, Davies, Neil M., Dudbridge, Frank, Gill, Dipender, Glymour, M. Maria, Hartwig, Fernando P., Holmes, Michael V., Minelli, Cosetta, Relton, Caroline L., Theodoratou, Evropi

“…This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up…”
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Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke by Holmes, Michael V., Millwood, Iona Y., Kartsonaki, Christiana, Hill, Michael R., Bennett, Derrick A., Boxall, Ruth, Guo, Yu, Xu, Xin, Bian, Zheng, Hu, Ruying, Walters, Robin G., Chen, Junshi, Ala-Korpela, Mika, Parish, Sarah, Clarke, Robert J., Peto, Richard, Collins, Rory, Li, Liming, Chen, Zhengming

“…Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and…”
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The Innate Immune Response of Eusocial Hymenopterans to Viral Pathogen Challenge by Holmes, V. Renee, Johnston, J. Spencer

“…In recent years, insect immunology has expanded rapidly in research interest, and available literature has expanded in kind. Insects combat pathogens through a…”
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Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants by Borges, Maria Carolina, Haycock, Philip C, Zheng, Jie, Hemani, Gibran, Holmes, Michael V, Davey Smith, George, Hingorani, Aroon D, Lawlor, Deborah A

“…Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence…”
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The Genomic Basis of Evolutionary Novelties in a Leafhopper by Li, Zheng, Li, Yiyuan, Xue, Allen Z, Dang, Vy, Holmes, V Renee, Johnston, J Spencer, Barrick, Jeffrey E, Moran, Nancy A

“…Abstract Evolutionary innovations generate phenotypic and species diversity. Elucidating the genomic processes underlying such innovations is central to…”
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Selecting instruments for Mendelian randomization in the wake of genome-wide association studies by Swerdlow, Daniel I, Kuchenbaecker, Karoline B, Shah, Sonia, Sofat, Reecha, Holmes, Michael V, White, Jon, Mindell, Jennifer S, Kivimaki, Mika, Brunner, Eric J, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D

“…Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental exposures or disease biomarkers, using genetic variants that…”
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Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance by Stringham, Nicole T., Holmes, Philip V., Stringham, James M.

“…Oxidative and inflammatory processes play a major role in stress-induced neural atrophy. There is a wide body of literature linking oxidative and inflammatory…”
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Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms by SCIOLINO, Natale R, HOLMES, Philip V

“…Although physical activity reduces anxiety in humans, the neural basis for this response is unclear. Rodent models are essential to understand the mechanisms…”
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Bats: Important Reservoir Hosts of Emerging Viruses by CALISHER, Charles H, CHILDS, James E, FIELD, Hume E, HOLMES, Kathryn V, SCHOUNTZ, Tony

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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