Search Results - "Holmes, Roxanne"
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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Published in Nature (London) (30-08-2012)“…Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation…”
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The OP9-DL1 system: generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro
Published in Cold Spring Harbor protocols (01-02-2009)Get more information
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Adapting in vitro embryonic stem cell differentiation to the study of locus control regions
Published in Journal of immunological methods (01-05-2014)“…Numerous locus control region (LCR) activities have been discovered in gene loci important to immune cell development and function. LCRs are a distinct class…”
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Complete TCR-α gene locus control region activity in T cells derived in vitro from embryonic stem cells
Published in The Journal of immunology (1950) (01-07-2013)“…Locus control regions (LCRs) are cis-acting gene regulatory elements with the unique, integration site-independent ability to transfer the characteristics of…”
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Derivation of T Cells In Vitro from Mouse Embryonic Stem Cells
Published in Journal of visualized experiments (14-10-2014)Get full text
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Derivation of T cells in vitro from mouse embryonic stem cells
Published in Journal of visualized experiments (14-10-2014)“…The OP9/OP9-DL1 co-culture system has become a well-established method for deriving differentiated blood cell types from embryonic and hematopoietic…”
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Directed differentiation of embryonic stem cells to the T-lymphocyte lineage
Published in Methods in molecular biology (Clifton, N.J.) (2013)“…Hematopoiesis is the highly regulated and complex process by which blood cells are formed. Hematopoiesis can be achieved in vitro by the differentiation of…”
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