Search Results - "Holmes, O."

mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations by Holmes, Alexandra O. M, Goldman, Adrian, Kalli, Antreas C

“…Membrane-integral pyrophosphatases (mPPases) are membrane-bound enzymes responsible for hydrolysing inorganic pyrophosphate and translocating a cation across…”
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Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers by Nones, K., Johnson, J., Newell, F., Patch, A.M., Thorne, H., Kazakoff, S.H., de Luca, X.M., Parsons, M.T., Ferguson, K., Reid, L.E., McCart Reed, A.E., Srihari, S., Lakis, V., Davidson, A.L., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., Beesley, J., Harris, J.M., Barnes, D., Degasperi, A., Ragan, M.A., Spurdle, A.B., Khanna, K.K., Lakhani, S.R., Pearson, J.V., Nik-Zainal, S., Chenevix-Trench, G., Waddell, N., Simpson, P.T.

“…Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated…”
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Carrier-controlled ferromagnetism in transparent oxide semiconductors by Philip, J, Moodera, J. S, Punnoose, A, Kim, B. I, Reddy, K. M, Layne, S, Holmes, J. O, Satpati, B, LeClair, P. R, Santos, T. S

“…The search for an ideal magnetic semiconductor with tunable ferromagnetic behaviour over a wide range of doping or by electrical gating is being actively…”
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Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC2 155 Reveals Sodium-Driven GABA Transport by Pavić, Ana, Ji, Yurui, Serafini, Agnese, Garza-Garcia, Acely, McPhillie, Martin J, Holmes, Alexandra O. M, de Carvalho, Luiz Pedro Sório, Wang, Yingying, Bartlam, Mark, Goldman, Adrian, Postis, Vincent L. G

“…Characterizing the mycobacterial transporters involved in the uptake and/or catabolism of host-derived nutrients required by mycobacteria may identify novel…”
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The Function of Membrane Integral Pyrophosphatases From Whole Organism to Single Molecule by Holmes, Alexandra O M, Kalli, Antreas C, Goldman, Adrian

“…Membrane integral pyrophosphatases (mPPases) are responsible for the hydrolysis of pyrophosphate. This enzymatic mechanism is coupled to the pumping of H or Na…”
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Hidradenitis suppurativa: haploinsufficiency of gamma-secretase components does not affect gamma-secretase enzyme activity in vitro by Pink, A.E., Dafou, D., Desai, N., Holmes, O., Hobbs, C., Smith, C.H., Mortimer, P., Simpson, M.A, Trembath, R.C., Barker, J.N.

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PO-0690: Patient weight loss predicts worse overall survival for stage I lung cancer treated with SABR by Cook, G, Xu, Y, Cross, P, Holmes, O, Macrae, R, Pantarotto, J

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Insights into the Structure/Function of Hepatocyte Growth Factor/Scatter Factor from Studies with Individual Domains by Holmes, O., Pillozzi, S., Deakin, J.A., Carafoli, F., Kemp, L., Butler, P.J.G., Lyon, M., Gherardi, E.

“…Hepatocyte growth factor/scatter factor (HGF/SF), the ligand for the receptor tyrosine kinase encoded by the c-Met proto-oncogene, is a multidomain protein…”
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Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels by Ramarao-Milne, P., Kondrashova, O., Patch, A.-M., Nones, K., Koufariotis, L.T., Newell, F., Addala, V., Lakis, V., Holmes, O., Leonard, C., Wood, S., Xu, Q., Mukhopadhyay, P., Naeini, M.M., Steinfort, D., Williamson, J.P., Bint, M., Pahoff, C., Nguyen, P.T., Twaddell, S., Arnold, D., Grainge, C., Basirzadeh, F., Fielding, D., Dalley, A.J., Chittoory, H., Simpson, P.T., Aoude, L.G., Bonazzi, V.F., Patel, K., Barbour, A.P., Fennell, D.A., Robinson, B.W., Creaney, J., Hollway, G., Pearson, J.V., Waddell, N.

“…Next-generation sequencing is used in cancer research to identify somatic and germline mutations, which can predict sensitivity or resistance to therapies, and…”
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Vasospasm and stroke attributable to ephedra-free xenadrine: case report by Holmes, Jr, Robert O, Tavee, Jinny

“…Following the 2004 ban of ephedra, which was linked to several cases of stroke and myocardial infarction, manufacturers have marketed "ephedra-free" weight…”
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Sci‐Fri AM: YIS‐04: Scatter correction of cone beam optical computed tomography for polymer gel dosimetry by Holmes, O, Olding, T, Schreiner, LJ

“…Optical computed tomography (OptCT) may become the preferred scanning method for gel dosimetry dose validations, due to its high sensitivity and relatively low…”
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Glutamate transporters: a broad review of the most recent archaeal and human structures by Pavić, Ana, Holmes, Alexandra O M, Postis, Vincent L G, Goldman, Adrian

“…Glutamate transporters play important roles in bacteria, archaea and eukaryotes. Their function in the mammalian central nervous system is essential for…”
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Poster — Thurs Eve‐42: A revision of the γ‐evaluation: Initial interpretation of dose disagreements on γ‐vector fields by Holmes, O, Darko, J, Dhanesar, S, Olding, T, Schreiner, LJ

“…Gamma evaluations are a common clinical tool used as a quantitative comparison between dose‐distributions, combining both dose difference and distance to…”
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Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC 2 155 Reveals Sodium-Driven GABA Transport by Pavić, Ana, Ji, Yurui, Serafini, Agnese, Garza-Garcia, Acely, McPhillie, Martin J, Holmes, Alexandra O M, de Carvalho, Luiz Pedro Sório, Wang, Yingying, Bartlam, Mark, Goldman, Adrian, Postis, Vincent L G

“…Characterizing the mycobacterial transporters involved in the uptake and/or catabolism of host-derived nutrients required by mycobacteria may identify novel…”
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The Effects of Emotional Expression on Vibrato by Dromey, Christopher, Holmes, Sharee O, Hopkin, J. Arden, Tanner, Kristine

“…Summary Objectives/Hypothesis The purpose of this study was to investigate the effect of emotional expression on several acoustic measures of vibrato,…”
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NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma by Grauzam, Stéphane, Brock, Amanda M, Holmes, Casey O, Tiedeken, Jessica A, Boniface, Samantha G, Pierson, Bailey N, Patterson, Daniel G, Coaxum, Sonya D, Neskey, David M, Rosenzweig, Steven A

“…Neural precursor cell expressed developmentally downregulated 9 (NEDD9) is a component of the metastatic signatures of melanoma, breast cancer, glioblastoma,…”
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Dual High Titer Antineutrophil Cytoplasmic Autoantibodies in Association With Systemic Q Fever by Holmes, Robert O, Hartzell, Joshua D, Tofferi, Jeanne K, Roebuck, Jonathan D, Kelly, William F

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P184 An evaluation of virtual Cystic Fibrosis-Related Diabetes (CFRD) clinics in the adult service during the COVID-19 pandemic in Northern Ireland (NI) by Molloy, E., Holmes, O., O’Neill, D., Rendall, J., Nugent, A.

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Hypofractionated versus conventionally fractionated radiotherapy for localized prostate cancer: Systematic review and meta-analysis of the randomized trials in the dose-escalation era by Morgan, S, Holmes, O, Malone, S

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The intracortical neuronal connectivity subserving focal epileptiform activity in rat neocortex by Holmes, O

“…In the anaesthetized rat, regions of the somatosensory cortex have been subpially isolated, leaving intact the cortical blood supply and the connectivity via…”
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