Search Results - "Holmes, Jennifer C."

The persistence of memory: the fate of ancient sedimentary organic carbon in a modern sedimentary system by Blair, Neal E, Leithold, Elana L, Ford, Shawn T, Peeler, Kelly A, Holmes, Jennifer C, Perkey, David W

“…The cycle of organic carbon burial and exhumation moderates atmospheric chemistry and global climate over geologic timescales. The burial of organic carbon…”
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Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K by Holmes, Jennifer C., Holmer, Savannah G., Ross, Peter, Buntzman, Adam S., Frelinger, Jeffrey A., Hess, Paul R.

“…Cytotoxic CD8+ T-cell immunosurveillance for intracellular pathogens, such as viruses, is controlled by classical major histocompatibility complex (MHC) class…”
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Dog leukocyte antigen‐88034:01 presents nonamer peptides from canine distemper virus hemagglutinin, large polymerase, and matrix proteins by Nemec, Paige S., Holmes, Jennifer C., Hess, Paul R.

“…Canine spontaneous cancers may offer greater fidelity than rodent models in advancing clinical immunotherapies. Boxers in particular are distinguished as study…”
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High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing by Holmes, Jennifer C., Scholl, Elizabeth H., Dickey, Allison N., Hess, Paul R.

“…Of the 12 full-length feline leukocyte antigen class I (FLAI) loci, 3 are presumed to be classical: FLAI-E , FLAI-H , and FLAI-K . As diversity is a class Ia…”
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The prevalent Boxer MHC class Ia allotype dog leukocyte antigen (DLA)‐88034:01 preferentially binds nonamer peptides with a defined motif by Nemec, Paige S., Kapatos, Alexander, Holmes, Jennifer C., Hess, Paul R.

“…Development of effective immunotherapy for chemoresistant malignancies can be advanced by studies in spontaneous cancer models, such as the dog. A crucial…”
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Cancer‐testis antigens in canine histiocytic sarcoma and other malignancies by Nemec, Paige S., Kapatos, Alexander, Holmes, Jennifer C., Stowe, Devorah M., Hess, Paul R.

“…Cancer‐testis antigens (CTAs) are a category of self proteins aberrantly expressed in diverse malignancies, mostly solid tumours, due to epigenetic…”
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The canine MHC class Ia allele DLA-88508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif by Ross, Peter, Nemec, Paige S., Kapatos, Alexander, Miller, Keith R., Holmes, Jennifer C., Suter, Steven E., Buntzman, Adam S., Soderblom, Erik J., Collins, Edward J., Hess, Paul R.

“…•DLA-88*508:01 binds peptides 9–12 amino acids in length, preferring 9- and 11-mers.•Hydrophobic residues at positions 2, 3, and K, R or F at the C-terminus…”
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A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88 by Ross, Peter, Holmes, Jennifer C., Gojanovich, Gregory S., Hess, Paul R.

“…Identifying immunodominant CTL epitopes is essential for studying CD8+ T-cell responses in populations, but remains difficult, as peptides within antigens…”
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Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris) by Gojanovich, Gregory S., Ross, Peter, Holmer, Savannah G., Holmes, Jennifer C., Hess, Paul R.

“…•Genes for peptide exporter subunits TAP1 & TAP2 were sequenced from cDNA of dogs.•Canine TAP genes display limited polymorphisms across divergent breed…”
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Decoding the Feline Leukocyte Antigen MHC class I system via SMRT sequencing by Hess, Paul R., Holmes, Jennifer C., Dickey, Allison N., Scholl, Elizabeth H., Thorne, Jeffrey L.

“…Abstract CD8+ T-cell cytotoxicity is an important component of anti-viral immune responses and is restricted by MHC class I peptide presentation. Investigating…”
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The prevalent Boxer MHC class Ia allele Dog Leukocyte Antigen (DLA)-88034:01 presents 9-mer peptides with a defined binding motif by Hess, Paul R., Nemec, Paige S., Kapatos, Alexander, Holmes, Jennifer C.

“…Abstract Adoptive cell transfer (ACT) for chemoresistant malignancies can induce dramatic remissions and prolong life, but factors that determine T-cell…”
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Polymorphisms and Tissue Expression of the Feline Leukocyte Antigen Class I Loci FLAI-E, -H and -K by Holmes, Jennifer C., Holmer, Savannah G., Ross, Peter, Buntzman, Adam S., Frelinger, Jeffrey A., Hess, Paul R.

“…Cytotoxic CD8+ T-cell immunosurveillance for intracellular pathogens, such as viruses, is controlled by classical major histocompatibility complex (MHC) class…”
Get full text