Search Results - "Holmes, Jane L"

Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy by McCoull, William, Bailey, Andrew, Barton, Peter, Birch, Alan M, Brown, Alastair J H, Butler, Hayley S, Boyd, Scott, Butlin, Roger J, Chappell, Ben, Clarkson, Paul, Collins, Shelley, Davies, Robert M D, Ertan, Anne, Hammond, Clare D, Holmes, Jane L, Lenaghan, Carol, Midha, Anita, Morentin-Gutierrez, Pablo, Moore, Jane E, Raubo, Piotr, Robb, Graeme

“…GPR120 agonists have therapeutic potential for the treatment of diabetes, but few selective agonists have been reported. We identified an…”
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Selective palladium-catalysed amination of 4-chloropyridines with benzylamines using the Josiphos ligand by Hawkins, Janet L., Gregson, Clare L., Hassall, Lorraine A., Holmes, Jane L.

“…[Display omitted] A synthetic strategy for the synthesis of a library of 4-N-benzylamino-2-N-phenyl-pyridines is herein described. The approach involves a…”
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Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists by McCoull, William, Barton, Peter, Brown, Alastair J. H, Bowker, Suzanne S, Cameron, Jennifer, Clarke, David S, Davies, Robert D. M, Dossetter, Alexander G, Ertan, Anne, Fenwick, Mark, Green, Clive, Holmes, Jane L, Martin, Nathaniel, Masters, David, Moore, Jane E, Newcombe, Nicholas J, Newton, Claire, Pointon, Helen, Robb, Graeme R, Sheldon, Christopher, Stokes, Stephen, Morgan, David

“…Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer…”
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Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology by Johannes, Jeffrey W, Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A, Dishington, Allan P, Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L, Holmes, Jane L, Howard, Tina, Huang, Jian, Ioannidis, Stephanos, Kazmirski, Steven, Lamb, Michelle L, McGuire, Thomas M, Moore, Jane E, Ogg, Derek, Patel, Anil, Pike, Kurt G, Pontz, Timothy, Robb, Graeme R, Su, Nancy, Wang, Haiyun, Wu, Xiaoyun, Zhang, Hai-Jun, Zhang, Yue, Zheng, Xiaolan, Wang, Tao

“…The canonical Wnt pathway plays an important role in embryonic development, adult tissue homeostasis, and cancer. Germline mutations of several Wnt pathway…”
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Indazole-6-phenyl­cyclopropyl­carboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy by McCoull, William, Bailey, Andrew, Barton, Peter, Birch, Alan M, Brown, Alastair J. H, Butler, Hayley S, Boyd, Scott, Butlin, Roger J, Chappell, Ben, Clarkson, Paul, Collins, Shelley, Davies, Robert M. D, Ertan, Anne, Hammond, Clare D, Holmes, Jane L, Lenaghan, Carol, Midha, Anita, Morentin-Gutierrez, Pablo, Moore, Jane E, Raubo, Piotr, Robb, Graeme

“…GPR120 agonists have therapeutic potential for the treatment of diabetes, but few selective agonists have been reported. We identified an…”
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