Search Results - "Holmes, Geoffrey R."

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism by Robertson, Anne L, Holmes, Geoffrey R, Bojarczuk, Aleksandra N, Burgon, Joseph, Loynes, Catherine A, Chimen, Myriam, Sawtell, Amy K, Hamza, Bashar, Willson, Joseph, Walmsley, Sarah R, Anderson, Sean R, Coles, Mark C, Farrow, Stuart N, Solari, Roberto, Jones, Simon, Prince, Lynne R, Irimia, Daniel, Rainger, G Ed, Kadirkamanathan, Visakan, Whyte, Moira K B, Renshaw, Stephen A

“…Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to…”
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Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial by Burton, Maria, Lifford, Kate J, Wyld, Lynda, Armitage, Fiona, Ring, Alistair, Nettleship, Anthony, Collins, Karen, Morgan, Jenna, Reed, Malcolm W R, Holmes, Geoffrey R, Bradburn, Mike, Gath, Jacqui, Green, Tracy, Revell, Deirdre, Brain, Kate, Edwards, Adrian

“…The Bridging the Age Gap in Breast Cancer research programme sought to improve treatment decision-making for older women with breast cancer by developing and…”
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The neutrophil's eye-view: inference and visualisation of the chemoattractant field driving cell chemotaxis in vivo by Kadirkamanathan, Visakan, Anderson, Sean R, Billings, Stephen A, Zhang, Xiliang, Holmes, Geoffrey R, Reyes-Aldasoro, Constantino C, Elks, Philip M, Renshaw, Stephen A

“…As we begin to understand the signals that drive chemotaxis in vivo, it is becoming clear that there is a complex interplay of chemotactic factors, which…”
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Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model by Holmes, Geoffrey R., Dixon, Giles, Anderson, Sean R., Reyes-Aldasoro, Constantino Carlos, Elks, Philip M., Billings, Stephen A., Whyte, Moira K. B., Kadirkamanathan, Visakan, Renshaw, Stephen A.

“…Neutrophils must be removed from inflammatory sites for inflammation to resolve. Recent work in zebrafish has shown neutrophils can migrate away from…”
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Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer by Battisti, Nicolò Matteo Luca, Reed, Malcolm W.R., Herbert, Esther, Morgan, Jenna L., Collins, Karen A., Ward, Sue E., Holmes, Geoffrey R., Bradburn, Michael, Walters, Stephen J., Burton, Maria, Lifford, Kate, Edwards, Adrian, Robinson, Thompson G., Martin, Charlene, Chater, Tim, Pemberton, Kirsty J., Shrestha, Anne, Brennan, Alan, Cheung, Kwok L., Todd, Annaliza, Audisio, Riccardo A., Wright, Juliet, Simcock, Richard, Green, Tracey, Revell, Deirdre, Gath, Jacqui, Horgan, Kieran, Holcombe, Chris, Winter, Matthew C., Naik, Jay, Parmeshwar, Rishi, Gosney, Margot A., Hatton, Matthew Q., Thompson, Alastair M., Wyld, Lynda, Ring, Alistair

“…Older patients with early breast cancer (EBC) derive modest survival benefit from chemotherapy but have increased toxicity risk. Data on the impact of…”
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Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer by Ring, Alistair, Battisti, Nicolò Matteo Luca, Reed, Malcolm W. R., Herbert, Esther, Morgan, Jenna L., Bradburn, Michael, Walters, Stephen J., Collins, Karen A., Ward, Sue E., Holmes, Geoffrey R., Burton, Maria, Lifford, Kate, Edwards, Adrian, Robinson, Thompson G., Martin, Charlene, Chater, Tim, Pemberton, Kirsty J., Brennan, Alan, Cheung, Kwok Leung, Todd, Annaliza, Audisio, Riccardo A., Wright, Juliet, Simcock, Richard, Green, Tracey, Revell, Deirdre, Gath, Jacqui, Horgan, Kieran, Holcombe, Chris, Winter, Matthew C., Naik, Jay, Parmeshwar, Rishi, Gosney, Margot A., Hatton, Matthew Q., Thompson, Alastair M., Wyld, Lynda

“…Background Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients but is infrequently offered to older individuals. This study…”
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Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life by Wyld, Lynda, Reed, Malcolm W.R., Morgan, Jenna, Collins, Karen, Ward, Sue, Holmes, Geoffrey R., Bradburn, Mike, Walters, Stephen, Burton, Maria, Herbert, Esther, Lifford, Kate, Edwards, Adrian, Ring, Alistair, Robinson, Thompson, Martin, Charlene, Chater, Tim, Pemberton, Kirsty, Shrestha, Anne, Brennan, Alan, Cheung, Kwok L., Todd, Annaliza, Audisio, Riccardo, Wright, Juliet, Simcock, Richard, Green, Tracy, Revell, Deirdre, Gath, Jacqui, Horgan, Kieran, Holcombe, Chris, Winter, Matt, Naik, Jay, Parmeshwar, Rishi, Patnick, Julietta, Gosney, Margot, Hatton, Matthew, Thomson, Alastair M.

“…Age-related breast cancer treatment variance is widespread with many older women having primary endocrine therapy (PET), which may contribute to inferior…”
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Differences in treatment and survival of older patients with operable breast cancer between the United Kingdom and the Netherlands – A comparison of two national prospective longitudinal multi-centre cohort studies by van der Plas-Krijgsman, Willeke G., Morgan, Jenna L., de Glas, Nienke A., de Boer, Anna Z., Martin, Charlene L., Holmes, Geoffrey R., Ward, Susan E., Chater, Tim, Reed, Malcolm W., Merkus, Jos W.S., van Dalen, Thijs, Vulink, Annelie J.E., van Gerven, Leander, Guicherit, Onno R., Linthorst-Niers, Eugenie, Lans, Titia E., Bastiaannet, Esther, Portielje, Johanneke E.A., Liefers, Gerrit Jan, Wyld, Lynda

“…Previous studies have shown that survival outcomes for older patients with breast cancer vary substantially across Europe, with worse survival reported in the…”
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Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality by Battisti, Nicolò Matteo Luca, Hatton, Matthew Q., Reed, Malcolm W.R., Herbert, Esther, Morgan, Jenna L., Bradburn, Michael, Simcock, Richard, Walters, Stephen J., Collins, Karen A., Ward, Sue E., Holmes, Geoffrey R., Burton, Maria, Lifford, Kate J., Edwards, Adrian, Robinson, Thompson G., Martin, Charlene, Chater, Tim, Pemberton, Kirsty J., Brennan, Alan, Leung Cheung, Kwok, Todd, Annaliza, Audisio, Riccardo A., Wright, Juliet, Green, Tracy, Revell, Deirdre, Gath, Jacqui, Horgan, Kieran, Holcombe, Chris, Winter, Matthew C., Naik, Jay, Parmeshwar, Rishi, Gosney, Margot A., Thompson, Alastair M., Wyld, Lynda, Ring, Alistair

“…•Radiotherapy use in older early-stage breast cancer patients is affected by age and relapse risk.•Despite geographical variation, geriatric parameters do not…”
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Cost-Effectiveness Modeling of Surgery Plus Adjuvant Endocrine Therapy Versus Primary Endocrine Therapy Alone in UK Women Aged 70 and Over With Early Breast Cancer by Holmes, Geoffrey R., Ward, Sue E., Brennan, Alan, Bradburn, Michael, Morgan, Jenna L., Reed, Malcolm W.R., Richards, Paul, Rafia, Rachid, Wyld, Lynda, Burton, Maria, Lifford, Kate, Edwards, Adrian, Walters, Stephen, Ring, Alistair, Robinson, Thompson, Martin, Charlene, Chater, Tim, Pemberton, Kirsty, Cheung, Kwok Leung, Todd, Annaliza, Brain, Kate, Audisio, Riccardo A., Wright, Juliette, Simcock, Richard, Thomson, Alistair, Gosney, Margot, Hatton, Matthew, Green, Tracy, Revill, Deirdre, Gath, Jacqui

“…Approximately 20% of UK women aged 70+ with early breast cancer receive primary endocrine therapy (PET) instead of surgery. PET reduces surgical morbidity but…”
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Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling by Holmes, Geoffrey R., Anderson, Sean R., Dixon, Giles, Robertson, Anne L., Reyes-Aldasoro, Constantino Carlos, Billings, Stephen A., Renshaw, Stephen A., Kadirkamanathan, Visakan

“…Following neutralization of infectious threats, neutrophils must be removed from inflammatory sites for normal tissue function to be restored. Recently, a new…”
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A Bayesian framework for identifying cell migration dynamics by Holmes, Geoffrey R., Anderson, Sean R., Dixon, Giles, Renshaw, Stephen A., Kadirkamanathan, Visakan

“…Cell migration is a vital process in living organisms. In particular we are interested in the way that white blood cells such as neutrophils migrate during…”
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