Search Results - "Holmes, Emiko J."

Primary Neurosurgery for Pediatric Low-Grade Gliomas: A Prospective Multi-Institutional Study From the Children's Oncology Group by Wisoff, Jeffrey H., Sanford, Robert A., Heier, Linda A., Sposto, Richard, Burger, Peter C., Yates, Allan J., Holmes, Emiko J., Kun, Larry E.

“…Abstract BACKGROUND: Central nervous system neoplasms are the most common solid tumors in children, and more than 40% are low-grade gliomas. Variable…”
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Outcome of Children With Metastatic Medulloblastoma Treated With Carboplatin During Craniospinal Radiotherapy: A Children's Oncology Group Phase I/II Study by JAKACKI, Regina I, BURGER, Peter C, FITZ, Charles, VEZINA, Gilbert, HILDEN, Joanne, POLLACK, Ian F, TIANNI ZHOU, HOLMES, Emiko J, KOCAK, Mehmet, ONAR, Arzu, GOLDWEIN, Joel, MEHTA, Minesh, PACKER, Roger J, TARBELL, Nancy

“…We evaluated the feasibility of administering carboplatin as a radiosensitizer during craniospinal radiation therapy (CSRT) to patients with high-risk…”
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IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group by Pollack, Ian F, Hamilton, Ronald L, Sobol, Robert W, Nikiforova, Marina N, Lyons-Weiler, Maureen A, LaFramboise, William A, Burger, Peter C, Brat, Daniel J, Rosenblum, Marc K, Holmes, Emiko J, Zhou, Tianni, Jakacki, Regina I

“…Purpose Recent studies have demonstrated a high frequency of IDH mutations in adult “secondary” malignant gliomas arising from preexisting lower grade lesions,…”
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Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children’s Oncology Group by Pollack, Ian F., Hamilton, Ronald L., Burger, Peter C., Brat, Daniel J., Rosenblum, Marc K., Murdoch, Geoffrey H., Nikiforova, Marina N., Holmes, Emiko J., Zhou, Tianni, Cohen, Kenneth J., Jakacki, Regina I.

“…Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN , which allows…”
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Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group by Cohen, Kenneth J., Heideman, Richard L., Zhou, Tianni, Holmes, Emiko J., Lavey, Robert S., Bouffet, Eric, Pollack, Ian F.

“…An open-label phase II study (ACNS0126) testing the efficacy of chemoradiotherapy with temozolomide (TMZ) followed by adjuvant TMZ was conducted by the…”
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Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group by Cohen, Kenneth J., Pollack, Ian F., Zhou, Tianni, Buxton, Allen, Holmes, Emiko J., Burger, Peter C., Brat, Daniel J., Rosenblum, Marc K., Hamilton, Ronald L., Lavey, Robert S., Heideman, Richard L.

“…To determine whether temozolomide is an active agent in the treatment of children with high-grade astrocytomas and whether survival is influenced by the…”
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Association between chromosome 1p and 19q loss and outcome in pediatric malignant gliomas: results from the CCG-945 cohort by Pollack, Ian F, Finkelstein, Sydney D, Burnham, Judith, Hamilton, Ronald L, Yates, Allan J, Holmes, Emiko J, Boyett, James M, Finlay, Jonathan L

“…Results of recent molecular studies on malignant gliomas in adults showed that deletions within the short arm of chromosome 1 and/or the long arm of chromosome…”
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Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma : a prospective study by the Children's oncology group by ROBERTSON, Patricia L, MURASZKO, Karin M, HOLMES, Emko J, SPOSTO, Richard, PACKER, Roger J, GAJJAR, Amar, DIAS, Mark S, ALLEN, Jeffrey C

“…Cerebellar mutism syndrome (CMS) is a unique postoperative syndrome typically arising 1 to 2 days after resection of a midline posterior fossa tumor; it…”
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Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood : results from the Children's Cancer Group 945 cohort by POLLACK, Ian F, HAMILTON, Ronald L, JAMES, C. David, FINKELSTEIN, Sydney D, BURNHAM, Judith, YATES, Allan J, HOLMES, Emiko J, TIANNI ZHOU, FINLAY, Jonathan L

“…In reporting on molecular studies involving malignant gliomas in adults, authors have noted that deletions of PTEN and amplification of EGFR are common and may…”
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Expression of p53 and Prognosis in Children with Malignant Gliomas by Pollack, Ian F, Finkelstein, Sydney D, Woods, Jeffrey, Burnham, Judith, Holmes, Emiko J, Hamilton, Ronald L, Yates, Allan J, Boyett, James M, Finlay, Jonathan L, Sposto, Richard

“…The clinical and histologic features of high-grade gliomas in children are not always useful prognostic indicators. This study investigated the prognostic…”
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Age and TP53 mutation frequency in childhood malignant gliomas: Results in a multi-institutional cohort by POLLACK, Ian F, FINKELSTEIN, Sydney D, BURNHAM, Judith, HOLMES, Emiko J, HAMILTON, Ronald L, YATES, Allan J, FINLAY, Jonathan L, SPOSTO, Richard

“…Malignant astrocytoma is one of the most deadly primary central nervous system tumors. Although significant progress has been made in understanding the…”
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Treatment Outcome and Prognostic Factors for Infants With Acute Lymphoblastic Leukemia Treated on Two Consecutive Trials of the Children's Cancer Group by REAMAN, G. H, SPOSTO, R, JOHNSTONE, H. S, O'BRIEN, R. T, STEINHERZ, P. G, ZELTZER, P. M, GAYNON, P. S, TRIGG, M. E, UCKUN, F. M, SENSEL, M. G, LANGE, B. J, FEUSNER, J. H, HEEREMA, N. A, LEONARD, M, HOLMES, E. J, SATHER, H. N, PENDERGRASS, T. W

“…Infants represent a very poor risk group for acute lymphoblastic leukemia (ALL). We report treatment outcome for such patients treated with intensive therapy…”
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Impact of proliferation index on outcome in childhood malignant gliomas: results in a multi-institutional cohort by Pollack, Ian F, Hamilton, Ronald L, Burnham, Judith, Holmes, Emiko J, Finkelstein, Sydney D, Sposto, Richard, Yates, Allan J, Boyett, James M, Finlay, Jonathan L

“…Prognoses of pediatric high-grade gliomas are unpredictable, even when clinical and histological factors are taken into account. In preliminary studies with an…”
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O6-Methylguanine-DNA Methyltransferase Expression Strongly Correlates With Outcome in Childhood Malignant Gliomas: Results From the CCG-945 Cohort by POLLACK, Ian F, HAMILTON, Ronald L, SOBOL, Robert W, BURNHAM, Judith, YATES, Allan J, HOLMES, Emiko J, TIANNI ZHOU, FINLAY, Jonathan L

“…O6-methylguanine-DNA methyltransferase (MGMT) functions to counteract the cytotoxic effects of alkylating agents, such as nitrosoureas, which play a central…”
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O 6 -Methylguanine-DNA Methyltransferase Expression Strongly Correlates With Outcome in Childhood Malignant Gliomas: Results From the CCG-945 Cohort by Pollack, Ian F., Hamilton, Ronald L., Sobol, Robert W., Burnham, Judith, Yates, Allan J., Holmes, Emiko J., Zhou, Tianni, Finlay, Jonathan L.

“…Purpose O 6 -Methylguanine-DNA methyltransferase (MGMT) functions to counteract the cytotoxic effects of alkylating agents, such as nitrosoureas, which play a…”
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Impact of Proliferation Index on Outcome in Childhood Malignant Gliomas: Results in a Multi-institutional Cohort by Pollack, Ian F., Hamilton, Ronald L., Burnham, Judith, Holmes, Emiko J., Finkelstein, Sydney D., Sposto, Richard, Yates, Allan J., Boyett, James M., Finlay, Jonathan L.

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Impact of proliferation index on outcome in childhood malignant gliomas: Results in a multi-institutional cohort. Commentary by POLLACK, Ian F, HAMILTON, Ronald L, BERGER, Mitchel S, MAPSTONE, Timothy B, RUTKA, James T, GILLES, Floyd, BURNHAM, Judith, HOLMES, Emiko J, FINKELSTEIN, Sydney D, SPOSTO, Richard, YATES, Allan J, BOYETT, James M, FINLAY, Jonathan L, SUTTON, Leslie N

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