Search Results - "Holmes, Edward C"

A Genomic Perspective on the Origin and Emergence of SARS-CoV-2 by Zhang, Yong-Zhen, Holmes, Edward C.

“…The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome…”
Get full text

The Ecology and Evolution of Influenza Viruses by Wille, Michelle, Holmes, Edward C

“…The patterns and processes of influenza virus evolution are of fundamental importance, underpinning such traits as the propensity to emerge in new host species…”
Get full text

The Evolution of Endogenous Viral Elements by Holmes, Edward C.

“…Endogenous retroviruses are a common component of the eukaryotic genome, and their evolution and potential function have attracted considerable interest. More…”
Get full text

Using Metagenomics to Characterize an Expanding Virosphere by Zhang, Yong-Zhen, Shi, Mang, Holmes, Edward C.

“…We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we…”
Get full text

The evolution of Ebola virus: Insights from the 2013–2016 epidemic by Holmes, Edward C., Dudas, Gytis, Rambaut, Andrew, Andersen, Kristian G.

“…The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically…”
Get full text

A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein by Zhou, Hong, Chen, Xing, Hu, Tao, Li, Juan, Song, Hao, Liu, Yanran, Wang, Peihan, Liu, Di, Yang, Jing, Holmes, Edward C., Hughes, Alice C., Bi, Yuhai, Shi, Weifeng

“…The unprecedented pandemic of pneumonia caused by a novel coronavirus, SARS-CoV-2, in China and beyond has had major public health impacts on a global scale…”
Get full text

Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families by Geoghegan, Jemma L, Duchêne, Sebastián, Holmes, Edward C

“…The cross-species transmission of viruses from one host species to another is responsible for the majority of emerging infections. However, it is unclear…”
Get full text

After the pandemic: perspectives on the future trajectory of COVID-19 by Telenti, Amalio, Arvin, Ann, Corey, Lawrence, Corti, Davide, Diamond, Michael S., García-Sastre, Adolfo, Garry, Robert F., Holmes, Edward C., Pang, Phillip S., Virgin, Herbert W.

“…There is a realistic expectation that the global effort in vaccination will bring the pandemic caused by severe acute respiratory syndrome coronavirus 2…”
Get full text

Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses by Zhou, Hong, Ji, Jingkai, Chen, Xing, Bi, Yuhai, Li, Juan, Wang, Qihui, Hu, Tao, Song, Hao, Zhao, Runchu, Chen, Yanhua, Cui, Mingxue, Zhang, Yanyan, Hughes, Alice C., Holmes, Edward C., Shi, Weifeng

“…Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic…”
Get full text

How accurately can we assess zoonotic risk? by Wille, Michelle, Geoghegan, Jemma L, Holmes, Edward C

“…Identifying the animal reservoirs from which zoonotic viruses will likely emerge is central to understanding the determinants of disease emergence…”
Get full text

A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology by Rambaut, Andrew, Holmes, Edward C., O’Toole, Áine, Hill, Verity, McCrone, John T., Ruis, Christopher, du Plessis, Louis, Pybus, Oliver G.

“…The ongoing pandemic spread of a new human coronavirus, SARS-CoV-2, which is associated with severe pneumonia/disease (COVID-19), has resulted in the…”
Get full text

The evolutionary history of vertebrate RNA viruses by Shi, Mang, Lin, Xian-Dan, Chen, Xiao, Tian, Jun-Hua, Chen, Liang-Jun, Li, Kun, Wang, Wen, Eden, John-Sebastian, Shen, Jin-Jin, Liu, Li, Holmes, Edward C., Zhang, Yong-Zhen

“…Our understanding of the diversity and evolution of vertebrate RNA viruses is largely limited to those found in mammalian and avian hosts and associated with…”
Get full text

What Does Virus Evolution Tell Us about Virus Origins? by HOLMES, Edward C

“…Author's Correction ( vol. 85 , p. 9655 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
Get full text

Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts by Troupin, Cécile, Dacheux, Laurent, Tanguy, Marion, Sabeta, Claude, Blanc, Hervé, Bouchier, Christiane, Vignuzzi, Marco, Duchene, Sebastián, Holmes, Edward C, Bourhy, Hervé

“…The natural evolution of rabies virus (RABV) provides a potent example of multiple host shifts and an important opportunity to determine the mechanisms that…”
Get full text

High-Resolution Metatranscriptomics Reveals the Ecological Dynamics of Mosquito-Associated RNA Viruses in Western Australia by Shi, Mang, Neville, Peter, Nicholson, Jay, Eden, John-Sebastian, Imrie, Allison, Holmes, Edward C

“…Mosquitoes harbor a high diversity of RNA viruses, including many that impact human health. Despite a growing effort to describe the extent and nature of the…”
Get full text

S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification by Valastro, Viviana, Holmes, Edward C., Britton, Paul, Fusaro, Alice, Jackwood, Mark W., Cattoli, Giovanni, Monne, Isabella

“…Infectious bronchitis virus (IBV) is the causative agent of a highly contagious disease that results in severe economic losses to the global poultry industry…”
Get full text

Predicting virus emergence amid evolutionary noise by Geoghegan, Jemma L., Holmes, Edward C.

“…The study of virus disease emergence, whether it can be predicted and how it might be prevented, has become a major research topic in biomedicine. Here we show…”
Get full text

The origins of SARS-CoV-2: A critical review by Holmes, Edward C., Goldstein, Stephen A., Rasmussen, Angela L., Robertson, David L., Crits-Christoph, Alexander, Wertheim, Joel O., Anthony, Simon J., Barclay, Wendy S., Boni, Maciej F., Doherty, Peter C., Farrar, Jeremy, Geoghegan, Jemma L., Jiang, Xiaowei, Leibowitz, Julian L., Neil, Stuart J.D., Skern, Tim, Weiss, Susan R., Worobey, Michael, Andersen, Kristian G., Garry, Robert F., Rambaut, Andrew

“…Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest…”
Get full text

Evolutionary Virology at 40 by Geoghegan, Jemma L, Holmes, Edward C

“…RNA viruses are diverse, abundant, and rapidly evolving. Genetic data have been generated from virus populations since the late 1970s and used to understand…”
Get full text

Rates of evolutionary change in viruses: patterns and determinants by Holmes, Edward C, Duffy, Siobain, Shackelton, Laura A

“…Key Points Viral mutation rates vary over five orders of magnitude, whereas viral substitution rates vary over six orders of magnitude. Instead of simplifying…”
Get full text