Search Results - "Holmes, Daniel"
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Heritable Remodeling of Yeast Multicellularity by an Environmentally Responsive Prion
Published in Cell (28-03-2013)“…Prion proteins undergo self-sustaining conformational conversions that heritably alter their activities. Many of these proteins operate at pivotal positions in…”
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Your results may vary: the imprecision of medical measurements
Published in BMJ (Online) (20-02-2020)“…[...]most importantly, there is biological variation. Biological variation comes about through the convergence of the innumerable perturbations of our…”
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Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis
Published in PLoS pathogens (01-05-2023)“…Kaposi's Sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's Sarcoma (KS), a highly vascularized tumor common in AIDS patients and many countries in…”
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Correct implementation of the Hoffmann method
Published in Clinical biochemistry (01-08-2019)Get full text
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Widespread Incorrect Implementation of the Hoffmann Method, the Correct Approach, and Modern Alternatives
Published in American journal of clinical pathology (04-02-2019)“…Abstract Objectives The Hoffmann method is a procedure for reference interval estimation using routine clinical results. Many authors incorrectly prepare…”
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A CRISPR-Cas9 screen identifies mitochondrial translation as an essential process in latent KSHV infection of human endothelial cells
Published in Proceedings of the National Academy of Sciences - PNAS (10-11-2020)“…Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL). The main proliferating…”
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Adrenal venous sampling for primary aldosteronism: laboratory medicine best practice
Published in Journal of clinical pathology (01-11-2017)“…Primary aldosteronism (PA) is the most common form of secondary hypertension and is critical to identify because when caused by an aldosterone-producing…”
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cp-R, an interface the R programming language for clinical laboratory method comparisons
Published in Clinical biochemistry (01-02-2015)“…Clinical scientists frequently need to compare two different bioanalytical methods as part of assay validation/monitoring. As a matter necessity, regression…”
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Self-Ordering Laboratory Testing: Limitations When a Physician Is not Part of the Model
Published in Clinics in laboratory medicine (01-03-2020)“…This review discusses considerations related to laboratory diagnostic testing purchased directly by consumers without the care and oversight of a medical…”
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Lithium related thyroid and parathyroid disease: Updated clinical practice guidelines are needed
Published in Journal of affective disorders (15-10-2023)“…This study aims to estimate the prevalence of and determine physician approaches to the screening and management of lithium-associated thyroid and parathyroid…”
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Bone turnover markers for assessment of anti-resorptive effect in clinical practice: A good idea meets the problem of measurement uncertainty
Published in Clinical biochemistry (01-06-2023)“…•A ß-CTX decline of 40% is suggested for osteoporosis therapy success in populations.•We modelled ß-CTX decreases incorporating measurement…”
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Concurrent solvent induced crystallization and hydrolytic degradation of PLA by water-ethanol solutions
Published in Polymer (Guilford) (02-09-2016)“…Poly(lactic acid) (PLA) films were immersed in pure water, 50% and 95% ethanol solutions for up to 180 days. The change in molecular weight, sorption of water,…”
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Quantitation of Aldosterone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Published in Methods in molecular biology (Clifton, N.J.) (2022)“…Accurate determination of serum and plasma aldosterone is essential for screening, diagnosis, and subtype classification of primary aldosteronism (PA). Its…”
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Age specific reference intervals for plasma biomarkers of neurodegeneration and neurotrauma in a Canadian population
Published in Clinical biochemistry (01-11-2023)“…INTRODUCTIONIn this study, we aimed to create reference intervals (RI) using a large Canadian population-based cohort, for plasma protein biomarkers with…”
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Laboratory challenges in primary aldosteronism screening and diagnosis
Published in Clinical biochemistry (01-04-2015)“…The laboratory has a critical role to play in the screening and diagnosis of primary aldosteronism. This review highlights some of the important analytical…”
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Recurrent Hypoglycemia from Insulin Autoimmune Syndrome
Published in Journal of general internal medicine : JGIM (01-01-2014)“…Insulin autoimmune syndrome (IAS) is an uncommon cause of hyperinsulinemic hypoglycemia characterized by autoantibodies to endogenous insulin in individuals…”
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Subcutaneous transplantation of human thyroid tissue into a pre-vascularized Cell Pouch™ device in a Mus musculus model: Evidence of viability and function for thyroid transplantation
Published in PloS one (20-01-2022)“…This study aimed to investigate the survival and efficacy indicators of human thyroid tissue transplantation into a retrievable, prevascularized implanted…”
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MPI collective communication through a single set of interfaces: A case for orthogonality
Published in Parallel computing (01-10-2021)“…We present and discuss a unified view of and interface for collective communication in the MPI (Message-Passing Interface) standard that in a natural way…”
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Older Adults Mount Less Durable Humoral Responses to Two Doses of COVID-19 mRNA Vaccine but Strong Initial Responses to a Third Dose
Published in The Journal of infectious diseases (21-09-2022)“…Abstract Background Third coronavirus disease 2019 (COVID-19) vaccine doses are broadly recommended, but immunogenicity data remain limited, particularly in…”
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