Search Results - "Holme, Kevin R."

Heparin in inflammation: potential therapeutic applications beyond anticoagulation by Tyrrell, D J, Horne, A P, Holme, K R, Preuss, J M, Page, C P

“…In this chapter we have described anti-inflammatory functions of heparin distinct from its traditional anticoagulant activity. We have presented in vivo data…”
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Chitosan derivatives bearing C10-alkyl glycoside branches: a temperature-induced gelling polysaccharide by Holme, Kevin R, Hall, L. D

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Heparinase enhances collateral vessel development in the ischemic limb by Pu, Lee L Q, Holme, Kevin R, Symes, James F

“…Several angiogenic factors are bound to heparin and stored in the extracellular matrix of diverse tissues; thus, the controlled release of these factors can…”
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Cholesteric properties of cellulose acetate and triacetate in trifluoroacetic acid by Ritcey, Anna M, Holme, Kevin R, Gray, Derek G

“…The optical properties of cellulose acetate and cellulose triacetate cholesteric liquid crystals in trifluoroacetic acid are investigated by circular…”
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Use of a Precise Intratracheal Delivery System to Compare the Acute Tolerance of Heparin and the Heparinoid GM2000 in Rabbits by D. Williams, David J. Tyrrell, Neal E. Storm, and Kevin R. Holme Roula Salame and Christopher Banks, Patricia

“…The pharmacological activity of heparin as a anti-inflammatory agent, has led to its proposed use in the treatment of asthma. However, the anticoagulant…”
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Chitosan N-sulfate. A water-soluble polyelectrolyte by Holme, Kevin R., Perlin, Arthur S.

“…Chitosans having degrees of acetylation (da) of 0.04, 0.10, and 0.22, respectively, were N-sulfated under a variety of reaction conditions. The derivatives…”
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Monitoring the purity of pharmaceutical heparin preparations by high-field 1H-nuclear magnetic resonance spectroscopy by Neville, G A, Mori, F, Holme, K R, Perlin, A S

“…High-field (300 MHz) 1H NMR spectral analyses are reported for various sodium or calcium heparin products available on the Canadian market. Dermatan sulfate…”
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Heparin in molluscs: chemical, enzymatic degradation and 13C and 1H n.m.r. spectroscopical evidence for the maintenance of the structure through evolution by Dietrich, C P, Nader, H B, de Paiva, J F, Santos, E A, Holme, K R, Perlin, A S

“…The structural features and anticoagulant activity of heparins isolated from three species of molluscs (Anomalocardia brasiliana, Donnax striatus and Tivela…”
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An Enzyme-Linked Immunosorbent Assay Using Biotinylated Heparan Sulfate to Evaluate the Interactions of Heparin-like Molecules and Basic Fibroblast Growth Factor by Foxall, Carrol, Holme, Kevin R., Liang, Weisheng, Wei, Zheng

“…Basic fibroblast growth factor (bFGF) is a member of the heparin-binding growth factor family that interacts with cell surface heparan sulfate (HS)…”
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Effects of nonanticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shock by Wang, P, Ba, Z F, Reich, S S, Zhou, M, Holme, K R, Chaudry, I H

“…Although heparinization of animals before hemorrhage improves cell and organ function, the potent anticoagulant activity of conventional heparin sodium…”
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Nuclear magnetic resonance spectra of heparin in admixture with dermatan sulfate and other glycosaminoglycans. 2-D spectra of the chondroitin sulfates by Holme, K R, Perlin, A S

“…Characteristics of the 1H-n.m.r. spectra of heparin admixed with other glycosaminoglycans are described with respect to the identification of the latter as…”
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Marked stereoselectivity in the binding of copper ions by heparin. Contrasts with the binding of gadolinium and calcium ions by Rej, R N, Holme, K R, Perlin, A S

“…Heparin forms a complex with cupric ion (Cu2+) at a level of less than or equal to 10(-3) mol of the metal ion per dimeric unit of the polymer, as evidenced by…”
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A Novel Nonanticoagulant Heparin Improves Splenocyte and Peritoneal Macrophage Immune Function after Trauma-Hemorrhage and Resuscitation by Zellweger, René, Ayala, Alfred, Zhu, Xiao-Lan, Holme, Kevin R., DeMaso, Catherine M., Chaudry, Irshad H.

“…Recent studies have shown that heparinization of animals prior to or even after hemorrhagic shock improves tissue perfusion and organ function. However, the…”
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Chemical composition, particle size range, and biological activity of some low molecular weight heparin derivatives by Neville, G A, Mori, F, Racey, T J, Rochon, P, Holme, K R, Perlin, A S

“…Several low molecular weight (LMW) heparin sodium derivatives from different sources, as well as some related regular heparin sodium preparations, were…”
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3-Azi-1-methoxybutyl beta-D-galactopyranoside, a photoaffinity label for monoclonal antigalactan antibodies of the VH GAL 39.1/55.1 gene-family by Jung, G L, Holme, K R, Glaudemans, C P, Lehmann, J, Lay, H

“…3-Azi-1-methoxybutyl beta-D-galactopyranoside, prepared from 2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl bromide in four steps, had an affinity constant…”
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Synthesis and evaluation of chitosan-based, affinity-chromatography materials by Holme, K R, Hall, L D, Armstrong, C R, Withers, S G

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