Search Results - "Holmberg, I"

Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis by Arpalahti, Leena, Laitinen, Alli, Hagström, Jaana, Mustonen, Harri, Kokkola, Arto, Böckelman, Camilla, Haglund, Caj, Holmberg, Carina I

“…Gastric cancer is the second most common cause of cancer-related mortality worldwide. Accurate prediction of disease progression is difficult, and new…”
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Insulin/IGF-1 Signaling Regulates Proteasome Activity through the Deubiquitinating Enzyme UBH-4 by Matilainen, Olli, Arpalahti, Leena, Rantanen, Ville, Hautaniemi, Sampsa, Holmberg, Carina I.

“…The proteasome plays an important role in proteostasis by carrying out controlled protein degradation in the cell. Impairments in proteasome function are…”
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Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans by Mikkonen, Elisa, Haglund, Caj, Holmberg, Carina I

“…The ubiquitin-proteasome system (UPS) plays a crucial part in normal cell function by mediating intracellular protein clearance. We have previously shown that…”
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Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity by Li, Xuan, Matilainen, Olli, Jin, Congyu, Glover-Cutter, Kira M, Holmberg, Carina I, Blackwell, T Keith

“…SKN-1, the Caenorhabditis elegans Nrf1/2/3 ortholog, promotes both oxidative stress resistance and longevity. SKN-1 responds to oxidative stress by…”
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Ultrahigh resolution topographic mapping of Mars with MRO HiRISE stereo images: Meter-scale slopes of candidate Phoenix landing sites by Kirk, R. L., Howington-Kraus, E., Rosiek, M. R., Anderson, J. A., Archinal, B. A., Becker, K. J., Cook, D. A., Galuszka, D. M., Geissler, P. E., Hare, T. M., Holmberg, I. M., Keszthelyi, L. P., Redding, B. L., Delamere, W. A., Gallagher, D., Chapel, J. D., Eliason, E. M., King, R., McEwen, A. S.

“…The objectives of this paper are twofold: first, to report our estimates of the meter‐to‐decameter‐scale topography and slopes of candidate landing sites for…”
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Tissue-Specific Impact of Autophagy Genes on the Ubiquitin-Proteasome System in C. elegans by Jha, Sweta, Holmberg, Carina I

“…The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two main eukaryotic intracellular proteolytic systems involved in…”
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Multisite phosphorylation provides sophisticated regulation of transcription factors by Holmberg, Carina I, Tran, Stefanie E.F, Eriksson, John E, Sistonen, Lea

“…Reversible phosphorylation is a prevalent mechanism by which the activity of eukaryotic transcription factors is regulated rapidly in response to changes in…”
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Phosphorylation of Serine 303 Is a Prerequisite for the Stress-Inducible SUMO Modification of Heat Shock Factor 1 by Hietakangas, Ville, Ahlskog, Johanna K., Jakobsson, Annika M., Hellesuo, Maria, Sahlberg, Niko M., Holmberg, Carina I., Mikhailov, Andrey, Palvimo, Jorma J., Pirkkala, Lila, Sistonen, Lea

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1 by Holmberg, Carina I., Hietakangas, Ville, Mikhailov, Andrey, Rantanen, Jouni O., Kallio, Marko, Meinander, Annika, Hellman, Jukka, Morrice, Nick, MacKintosh, Carol, Morimoto, Richard I., Eriksson, John E., Sistonen, Lea

“…Heat shock factor 1 (HSF1) is a serine‐rich constitutively phosphorylated mediator of the stress response. Upon stress, HSF1 forms DNA‐binding trimers,…”
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AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans by Pispa, Johanna, Mikkonen, Elisa, Arpalahti, Leena, Jin, Congyu, Martínez-Fernández, Carmen, Cerón, Julián, Holmberg, Carina I.

“…Polyubiquitinated proteins are primarily degraded by the ubiquitin-proteasome system (UPS). Proteasomes are present both in the cytoplasm and nucleus. Here, we…”
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BAP1 Malignant Pleural Mesothelioma Mutations in Caenorhabditis elegans Reveal Synthetic Lethality between ubh-4 / BAP1 and the Proteasome Subunit rpn-9 / PSMD13 by Martínez-Fernández, Carmen, Jha, Sweta, Aliagas, Elisabet, Holmberg, Carina I, Nadal, Ernest, Cerón, Julián

“…The deubiquitinase BAP1 (BRCA1-associated protein 1) is associated with tumor predisposition syndrome (TPDS). is a tumor suppressor gene whose alterations in…”
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Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates by Matsumoto, Gen, Stojanovic, Aleksandar, Holmberg, Carina I, Kim, Soojin, Morimoto, Richard I

“…The appearance of protein aggregates is a characteristic of protein misfolding disorders including familial amyotrophic lateral sclerosis, a neurodegenerative…”
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Nicotinamide riboside first alleviates symptoms but later downregulates dopamine metabolism in proteasome inhibition mouse model of Parkinson's disease by Turconi, Giorgio, Alam, Farhan, SenGupta, Tanima, Pirnes-Karhu, Sini, Olfat, Soophie, Schmidt, Mark S., Mätlik, Kärt, Montaño-Rodriguez, Ana, Heiskanen, Vladimir, Garton, Daniel, Piepponen, Petteri T., Brenner, Charles, Holmberg, Carina I., Nilsen, Hilde, Pirinen, Eija, Andressoo, Jaan-Olle

“…Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial…”
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Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma by Arpalahti, Leena, Saukkonen, Kapo, Hagström, Jaana, Mustonen, Harri, Seppänen, Hanna, Haglund, Caj, Holmberg, Carina I

“…Pancreatic ductal adenocarcinoma is a lethal disease with an overall 5-year survival of less than 5%. Prognosis among surgically treated patients is difficult…”
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UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer by Arpalahti, Leena, Hagström, Jaana, Mustonen, Harri, Lundin, Mikael, Haglund, Caj, Holmberg, Carina I

“…Colorectal cancer is among the three most common cancer types for both genders, with a rising global incidence. To date, prognostic evaluation is difficult and…”
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Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy‐mediated proteolysis in human retinal pigment epithelial cells by Ryhänen, Tuomas, Hyttinen, Juha M. T., Kopitz, Jürgen, Rilla, Kirsi, Kuusisto, Erkki, Mannermaa, Eliisa, Viiri, Johanna, Holmberg, Carina I., Immonen, Ilkka, Meri, Seppo, Parkkinen, Jussi, Eskelinen, Eeva‐Liisa, Uusitalo, Hannu, Salminen, Antero, Kaarniranta, Kai

“…The pathogenesis of age‐related macular degeneration involves chronic oxidative stress, impaired degradation of membranous discs shed from photoreceptor outer…”
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Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease by Feleciano, Diogo R, Juenemann, Katrin, Iburg, Manuel, Brás, Inês C, Holmberg, Carina I, Kirstein, Janine

“…A functional protein quality control machinery is crucial to maintain cellular and organismal physiology. Perturbation in the protein homeostasis network can…”
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Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants by Weinheimer, Isabel, Jiu, Yaming, Rajamäki, Minna-Liisa, Matilainen, Olli, Kallijärvi, Jukka, Cuellar, Wilmer J, Lu, Rui, Saarma, Mart, Holmberg, Carina I, Jäntti, Jussi, Valkonen, Jari P T

“…Certain RNA and DNA viruses that infect plants, insects, fish or poikilothermic animals encode Class 1 RNaseIII endoribonuclease-like proteins. dsRNA-specific…”
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Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans by Jiu, Yaming, Jin, Congyu, Liu, Yanbo, Holmberg, Carina I, Jäntti, Jussi

“…The exocyst complex is required for cell polarity regulation and the targeting and tethering of transport vesicles to the plasma membrane. The complex is…”
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Inefficient degradation of truncated polyglutamine proteins by the proteasome by Holmberg, Carina I, Staniszewski, Kristine E, Mensah, Kwame N, Matouschek, Andreas, Morimoto, Richard I

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