Search Results - "Holman, M C"

Hydrolysis of a Broad Spectrum of Extracellular Matrix Proteins by Human Macrophage Elastase by Gronski, Jr, T J, Martin, R L, Kobayashi, D K, Walsh, B C, Holman, M C, Huber, M, Van Wart, H E, Shapiro, S D

“…Macrophage elastase (ME) was originally named when metal-dependent elastolytic activity was detected in conditioned media of murine macrophages. Subsequent…”
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Distortion-Product and Click-Evoked Otoacoustic Emissions of Preterm and Full-Term Infants by Smurzynski, Jacek, Jung, Marjorie D, Lafreniere, Denis, Kim, D O, Kamath, M Vasudeva, Rowe, Jonelle C, Holman, Marlene C, Leonard, Gerald

“…ABSTRACTFull-term and preterm infants were evaluated with click-evoked and distortion product otoacoustic emissions [CEOEs and DPOEs]. The CEOEs and DWEs…”
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Potentially preventable hospitalizations for acute and chronic conditions in Alaska, 2010–2012 by Gounder, Prabhu P., MD, MPH, Seeman, Sara M., MSPH, Holman, Robert C., MS, Rarig, Alice, PhD, MA, MPH, McEwen, Mary K., MPH, Steiner, Claudia A., MD, MPH, Bartholomew, Michael L., MD, Hennessy, Thomas W., MD, MPH

“…Abstract Objective The U.S. Agency for Healthcare Research and Quality's Prevention Quality Indicators comprise acute and chronic conditions for which…”
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Role of His-224 in the Anomalous pH Dependence of Human Stromelysin-1 by Holman, Christopher M, Kan, Chen-Chen, Gehring, Michael R, Van Wart, Harold E

“…A plot of the pH dependence of k cat/K M for human stromelysin-1 (HS) exhibits a narrow range of maximal activity extending from pH 5.75 to 6.25 and a broad…”
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Purification of human matrilysin produced in Escherichia coli and characterization using a new optimized fluorogenic peptide substrate by Welch, A R, Holman, C M, Browner, M F, Gehring, M R, Kan, C C, Van Wart, H E

“…Human promatrilysin (matrix metalloproteinase-7) has been produced in Escherichia coli as an N-terminal fusion protein with ubiquitin. The insoluble product…”
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Patent border wars: defining the boundary between scientific discoveries and patentable inventions by Holman, Christopher M

“…Drawing an appropriate boundary between unpatentable natural phenomena and patentable inventions is crucial in preventing the patent laws from unduly…”
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Pedicle graft repair of an endodontic defect: report of case by Holman, C M, Marshall, F J

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Hospitalizations with Lower Respiratory Tract Infections among American Indian and Alaska Native Children Under Age 5 Years: The Use of Non-Federal Hospital Discharge Data to Analyze Rates by Singleton, Rosalyn, MD, MPH, Holman, Robert C., MS

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Respiratory Exacerbations in Indigenous Children From Two Countries With Non-Cystic Fibrosis Chronic Suppurative Lung Disease/Bronchiectasis by Redding, Gregory J., MD, FCCP, Singleton, Rosalyn J., MD, MPH, Valery, Patricia C., MD, PhD, MPH, Williams, Hayley, BSoc Sci, PGDipPsych, Grimwood, Keith, MB, ChB, MD, Morris, Peter S., MBBS, PhD, Torzillo, Paul J., MBBS, McCallum, Gabrielle B., MPH, RN, Chikoyak, Lori, RN, Holman, Robert C., MS, Chang, Anne B., MBBS, MPHTM, PhD

“…BACKGROUND Acute respiratory exacerbations (AREs) cause morbidity and lung function decline in children with chronic suppurative lung disease (CSLD) and…”
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Trends in Lower Respiratory Tract Infection Hospitalizations among American Indian/Alaska Native Children and the General US Child Population by Singleton, Rosalyn J., MD, Holman, Robert C., MS, Folkema, Arianne M., MPH, Wenger, Jay D., MD, Steiner, Claudia A., MD, Redd, John T., MD

“…Objective To describe trends in the rate of hospitalization for lower respiratory tract infection (LRTI) among American Indian/Alaska Native (AI/AN) children…”
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Insights into the catalytic mechanism and active-site environment of Comamonas testosteroni delta 5-3-ketosteroid isomerase as revealed by site-directed mutagenesis of the catalytic base aspartate-38 by Holman, C M, Benisek, W F

“…Delta 5-3-Ketosteroid isomerase (KSI) of Comamonas testosteroni catalyzes the isomerization of a wide variety of delta 5(6) and delta 5(10) steroids through…”
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Reconstruction of male external genitalia with elephantiasis by Holman, Jr, C M, Arnold, P G, Jurkiewicz, M J, Walton, K N

“…The surgical rehabilitation of a patient with severely deformed and functionally disabled genitalia due to long-standing lymphedema and infection is described…”
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Epidemiology of Asthma Hospitalizations Among American Indian and Alaska Native People and the General United States Population by Mehal, Jason M., MPH, Holman, Robert C., MS, Steiner, Claudia A., MD, MPH, Bartholomew, Michael L., MD, Singleton, Rosalyn J., MD

“…BACKGROUND Asthma, a common chronic disease among adults and children in the United States, results in nearly one-half million hospitalizations annually. There…”
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Understanding the P1‘ Specificity of the Matrix Metalloproteinases:  Effect of S1‘ Pocket Mutations in Matrilysin and Stromelysin-1 by Welch, Anthony R, Holman, Christopher M, Huber, Martin, Brenner, Mitchell C, Browner, Michelle F, Van Wart, Harold E

“…Matrilysin (MAT) prefers leucine over residues that have aromatic side chains at the P1‘ position of peptide and protein substrates, while stromelysin (HFS)…”
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Insights into the catalytic mechanism and active-site environment of Comamonas testosteroni Delta super(5)-3-ketosteroid isomerase as revealed by site-directed mutagenesis of the catalytic base aspartate-38 by Holman, C M, Benisek, W F

“…Delta super(5)-3-Ketosteroid isomerase (KSI) of Comamonas testosteroni catalyzes the isomerization of a wide variety of Delta super(5(6)) and Delta…”
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35,000 and a three-month summer break - and MPs have the nerve to demand more by Taunton, MC Holman

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Dog Bite Injuries among American Indian and Alaska Native Children by Bjork, Adam, PhD, Holman, Robert C., MS, Callinan, Laura S., MPH, Hennessy, Thomas W., MD, MPH, Cheek, James E., MD, MPH, McQuiston, Jennifer H., DVM, MS

“…Objective To examine dog bites among American Indian (AI) and Alaska Native (AN) children visiting Indian Health Service and tribal health facilities. Study…”
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Extent of proton transfer in the transition states of the reaction catalyzed by the delta 5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni: site-specific replacement of the active site base, aspartate 38, by the weaker base alanine-3-sulfinate by Holman, C M, Benisek, W F

“…Previous studies of the mechanism of the steroid isomerase of Comamonas (Pseudomonas) testosteroni have identified aspartate 38 as the proton porter which…”
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Extent of proton transfer in the transition states of the reaction catalyzed by the Δ5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni : site-specific replacement of the active site base, aspartate 38, by the weaker base alanine-3-sulfinate by HOLMAN, C. M, BENISEK, W. F

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Unexplained Death due to Possible Infectious Diseases in Infants—United States, 2006 by Taylor, Christopher A., PhD, Holman, Robert C., MS, Callinan, Laura S., MPH, Zaki, Sherif R., MD, PhD, Blau, Dianna M., DVM, PhD

“…Objectives To quantify and examine factors related to unexplained death due to possible infectious causes (UDPIC) in infants and to analyze the associations…”
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