Effect of inulin-type fructans on appetite in patients with type 2 diabetes: a randomised controlled crossover trial

The aim of the study was to investigate the effect of prebiotic fibres on appetite-regulating hormones, subjective feeling of appetite and energy intake in subjects with type 2 diabetes. Data presented are secondary outcomes of a study investigating the effect of prebiotics on glucagon-like peptide-...

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Published in:	Journal of nutritional science (Cambridge) Vol. 10; p. e72
Main Authors:	Birkeland, Eline, Gharagozlian, Sedegheh, Birkeland, Kåre I., Holm, Oda K. S., Thorsby, Per M., Aas, Anne-Marie
Format:	Journal Article
Language:	English
Published:	Cambridge, UK Cambridge University Press 2021
Subjects:	Appetite Bacteria Behaviour, Appetite and Obesity Cross-Over Studies Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes type 2 Diet Exercise Fatty acids Female Food Ghrelin Ghrelin - blood Hormones Hospitals Humans Insulin Intervention Inulin - administration & dosage Laboratories Male Metabolism Overweight Peptide YY - blood Peptides Physical fitness Prebiotics Prospective Studies PYY Satiation Standardised mixed meal Germany PYY Standardised mixed meal Ghrelin Diabetes type 2 Prebiotics VAS, visual analogue scale GLP-1, glucagon-like peptide-1 ITF, inulin-type fructans PYY, peptide YY
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Summary:	The aim of the study was to investigate the effect of prebiotic fibres on appetite-regulating hormones, subjective feeling of appetite and energy intake in subjects with type 2 diabetes. Data presented are secondary outcomes of a study investigating the effect of prebiotics on glucagon-like peptide-1 and glycaemic regulation. We conducted a randomised and placebo-controlled crossover trial to evaluate the effects of 16 g/d of inulin-type fructans or a control supplement (maltodextrin) for 6 weeks in randomised order, with a 4-week washout period in-between, on appetite in thirty-five men and women with type 2 diabetes. Data were collected at visits before and after each treatment: plasma concentration of the satiety-related peptides ghrelin and peptide YY (PYY) were assessed during a standardised mixed meal. The subjective sensation of appetite was evaluated in response to an ad libitum lunch by rating the visual analogue scale. Twenty-nine individuals (twelve women) were included in the analyses. Compared to control treatment, the prebiotics did not affect ghrelin (P =0⋅71) or the ratings of hunger (P = 0⋅62), satiety (P = 0⋅56), fullness (P = 0⋅73) or prospective food consumption (P = 0⋅98). Energy intake also did not differ between the treatments. However, the response of PYY increased significantly after the control treatment with mean (sem) 11⋅1 (4⋅3) pg/ml when compared to the prebiotics −0⋅3 (4⋅3) pg/ml (P = 0⋅013). We observed no effect of inulin-type fructans on appetite hormones, subjective feeling of appetite or energy intake in patients with type 2 diabetes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	2048-6790 2048-6790
DOI:	10.1017/jns.2021.70