Search Results - "Hollywood, Mark A"

Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor by Fong, Zhihui, Lall, Anshika, Mullins, Nicolas D., Santana, L. Fernando, Hollywood, Mark A., Thornbury, Keith D., Sergeant, Gerard P.

“…Purinergic contractions of the detrusor are reduced by cAMP, but the underlying mechanisms are unclear. We examined the effects of BK and Kv7 channel…”
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Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases by Carroll, Emma L, Bailo, Mariarca, Reihill, James A, Crilly, Anne, Lockhart, John C, Litherland, Gary J, Lundy, Fionnuala T, McGarvey, Lorcan P, Hollywood, Mark A, Martin, S Lorraine

“…Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1…”
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Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal by Fedigan, Stephen, Bradley, Eamonn, Webb, Timothy, Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., McHale, Noel G., Sergeant, Gerard P.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca 2+ -activated Cl − currents ( I ClCa ) that are important for the development of…”
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Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice by Griffin, Caoimhin S., Thornbury, Keith D., Hollywood, Mark A., Sergeant, Gerard P.

“…Acetylcholine contracts the bladder by binding to muscarinic M3 receptors on the detrusor, leading to Ca 2+ influx via voltage-gated Ca 2+ channels. The…”
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Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels by Griffin, Caoimhin S, Bradley, Eamonn, Dudem, Srikanth, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D, Sergeant, Gerard P

“…Purpose Muscarinic receptor mediated contractions of the detrusor rely on Ca2+ influx through voltage-gated Ca2+ channels but to our knowledge the mechanism…”
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The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T., Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., Baker, Salah A., Harvey, Brian J., McHale, Noel G., Sergeant, Gerard P.

“…Key points Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed…”
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Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells by Lim, Xin Rui, Drumm, Bernard T., Sergeant, Gerard P., Hollywood, Mark A., Thornbury, Keith D.

“…Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully…”
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Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment by Webb, Timothy I., Kshatri, Aravind Singh, Large, Roddy J., Akande, Adebola Morayo, Roy, Subhrangsu, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Significance Large-conductance Ca ²⁺-activated K ⁺ (BK) calcium-activated potassium channels alter the excitability of a wide variety of cells including nerves…”
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Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum by Pratt, Christopher P, Kuljis, Dika A, Homanics, Gregg E, He, Jianjun, Kolodieznyi, Dmytro, Dudem, Srikanth, Hollywood, Mark A, Barth, Alison L, Bruchez, Marcel P

“…BK channels are critical regulators of neuronal activity, controlling firing, neurotransmitter release, cerebellar function, and BK channel mutations have been…”
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ATP Evokes Inward Currents in Corpus Cavernosum Myocytes by Doyle, Claire, Sergeant, Gerard P., Hollywood, Mark A., McHale, Noel G., Thornbury, Keith D.

“…Although adenosine triphosphate (ATP) has often been reported to relax the corpus cavernosum, this may be mediated by indirect effects, such as release of…”
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Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra by Sergeant, Gerard P., Bradley, Eamonn, Thornbury, Keith D., McHale, Noel G., Hollywood, Mark A.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit pacemaker activity that results from spontaneous Ca 2+ waves. The purpose of this…”
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BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site by Chen, Guanxing, Li, Qin, Webb, Timothy I, Hollywood, Mark A, Yan, Jiusheng

“…The large-conductance, Ca2+-, and voltage-activated K+ (BK) channel consists of the pore-forming α (BKα) subunit and regulatory β and γ subunits. The γ1-3…”
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Igniting Ca2+ sparks with TRPML1 by Sergeant, Gerard P., Hollywood, Mark A., Thornbury, Keith D.

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Igniting Ca 2+ sparks with TRPML1 by Sergeant, Gerard P, Hollywood, Mark A, Thornbury, Keith D

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The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells by Dwivedi, Ritu, Drumm, Bernard T., Alkawadri, Tuleen, Martin, S. Lorraine, Sergeant, Gerard P., Hollywood, Mark A., Thornbury, Keith D.

“…We investigated effects of TMEM16A blockers benzbromarone, MONNA, CaCCinhA01 and Ani9 on isometric contractions in mouse bronchial rings and on intracellular…”
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Modulation of fast sodium current in airway smooth muscle cells by exchange protein directly activated by cAMP by Matthews, Ruth M, Bradley, Eamonn, Hollywood, Mark A, Lundy, Fionnuala T, McGarvey, Lorcan P, Sergeant, Gerard P, Thornbury, Keith D

“…Airway smooth muscle (ASM) cells from mouse bronchus express a fast sodium current mediated by Na 1.7. We present evidence that this current is regulated by…”
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Evidence of an excitatory purinergic innervation in mouse corpus cavernosum smooth muscle by Lim, Xin Rui, Mercer, Mitchell, Harraz, Osama F, Hollywood, Mark A, Sergeant, Gerard P, Thornbury, Keith D

“…Evidence suggests that the corpus cavernosum smooth muscle (CCSM) cells of several species, including humans, express purinergic P2X receptors, but it is not…”
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LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels by Dudem, Srikanth, Large, Roddy J., Kulkarni, Shruti, McClafferty, Heather, Tikhonova, Irina G., Sergeant, Gerard P., Thornbury, Keith D., Shipston, Michael J., Perrino, Brian A., Hollywood, Mark A.

“…LINGO1 is a transmembrane protein that is up-regulated in the cerebellum of patients with Parkinson’s disease (PD) and Essential Tremor (ET). Patients with…”
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Regulation of nerve-evoked contractions of the murine vas deferens by Wong, Pei Yee, Fong, Zhihui, Hollywood, Mark A., Thornbury, Keith D., Sergeant, Gerard P.

“…Stimulation of sympathetic nerves in the vas deferens yields biphasic contractions consisting of a rapid transient component resulting from activation of P2X1…”
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Spontaneous Ca2+ Waves in Rabbit Corpus Cavernosum: Modulation by Nitric Oxide and cGMP by Sergeant, Gerard P., Craven, Michael, Hollywood, Mark A., McHale, Noel G., Thornbury, Keith D.

“…Detumescent tone and subsequent relaxation by nitric oxide (NO) are essential processes that determine the erectile state of the penis. Despite this, the…”
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