Search Results - "Hollywood, M. A."

Specialised pacemaking cells in the rabbit urethra by Sergeant, G. P., Hollywood, M. A., McCloskey, K. D., Thornbury, K. D., McHale, N. G.

“…Collagenase dispersal of strips of rabbit urethra yielded, in addition to normal spindle-shaped smooth muscle cells, a small proportion of branched cells which…”
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Calcium oscillations in interstitial cells of the rabbit urethra by Johnston, L., Sergeant, G. P., Hollywood, M. A., Thornbury, K. D., McHale, N. G.

“…Measurements were made (using fast confocal microscopy) of intracellular Ca 2 + levels in fluo-4 loaded interstitial cells isolated from the rabbit urethra…”
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Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra by Kyle, B, Bradley, E, Ohya, S, Sergeant, G P, McHale, N G, Thornbury, K D, Hollywood, M A

“…We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and…”
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Organization and function of ICC in the urinary tract by McHale, N. G., Hollywood, M. A., Sergeant, G. P., Shafei, M., Thornbury, K. T., Ward, S. M.

“…ICC are found in both the upper and lower urinary tract. They are not found in the ureter itself but are confined to the lamina propria of the renal pelvis and…”
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The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells by Bradley, E, Webb, T I, Hollywood, M A, Sergeant, G P, McHale, N G, Thornbury, K D

“…A collagenase-proteinase mixture was used to isolate airway smooth muscle cells (ASMC) from rabbit bronchi, and membrane currents were recorded using the whole…”
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Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves by Sergeant, G. P., Johnston, Louise, McHale, N. G., Thornbury, K. D., Hollywood, M. A.

“…In the present study we used a combination of patch clamping and fast confocal Ca 2+ imaging to examine the effects of activators of the nitric oxide (NO)/cGMP…”
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Ca2+ signalling in urethral interstitial cells of Cajal by Sergeant, Gerard P., Hollywood, M. A., McHale, N. G., Thornbury, K. D.

“…Interstitial cells of Cajal (ICC) in the urethra have been proposed as specialized pacemakers that are involved in the generation of urethral tone and…”
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Ionic currents in intimal cultured synoviocytes from the rabbit by Large, R J, Hollywood, M A, Sergeant, G P, Thornbury, K D, Bourke, S, Levick, J R, McHale, N G

“…Hyaluronan, a joint lubricant and regulator of synovial fluid content, is secreted by fibroblast-like synoviocytes lining the joint cavity, and secretion is…”
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The PI‐PLC inhibitor U‐73122 is a potent inhibitor of the SERCA pump in smooth muscle by Hollywood, MA, Sergeant, GP, Thornbury, KD, McHale, NG

“…In this issue MacMillan and McCarron in 2010 demonstrated that the phospholipase C (PLC) inhibitor U‐73122 can potently inhibit Ca2+ release from isolated…”
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Contribution of reverse Na+–Ca2+ exchange to spontaneous activity in interstitial cells of Cajal in the rabbit urethra by Bradley, E., Hollywood, M. A., Johnston, L., Large, R. J., Matsuda, T., Baba, A., McHale, N. G., Thornbury, K. D., Sergeant, Gerard P.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit regular Ca 2+ oscillations that are associated with spontaneous transient inward…”
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Cajal beyond the gut: interstitial cells in the urinary system--towards general regulatory mechanisms of smooth muscle contractility? by Thornbury, K D, Hollywood, M A, McHale, N G, Sergeant, G P

“…Interstitial cells of Cajal (ICC), similar to GI pacemakers have been identified throughout the urinary system. Although each part of the system serves a…”
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Modulation of spontaneous Ca2+‐activated Cl− currents in the rabbit corpus cavernosum by the nitric oxide–cGMP pathway by Craven, M., Sergeant, G. P., Hollywood, M. A., McHale, N. G., Thornbury, K. D.

“…The whole‐cell perforated patch clamp technique was used to study membrane currents in isolated rabbit corpus cavernosum smooth muscle cells. Depolarization…”
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Characterization of norepinephrine-evoked inward currents in interstitial cells isolated from the rabbit urethra by Sergeant, G P, Thornbury, K D, McHale, N G, Hollywood, M A

“…Freshly dispersed interstitial cells from the rabbit urethra were studied by using the perforated-patch technique. When cells were voltage clamped at -60 mV…”
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Excitatory cholinergic responses in mouse primary bronchial smooth muscle require both Ca2+ entry via l-type Ca2+ channels and store operated Ca2+ entry via Orai channels by Dwivedi, R., Drumm, B.T., Griffin, C. S., Dudem, S., Bradley, E., Alkawadri, T., Martin, S.L., Sergeant, G.P., Hollywood, M.A., Thornbury, K.D.

“…•Ca2+ stores are essential for cholinergic responses in airways smooth muscle.•Ca2+ influx via Store operated Ca2+ Entry (SOCE) mediates cholinergic…”
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Characterization of T-type calcium current and its contribution to electrical activity in rabbit urethra by Bradley, J E, Anderson, U A, Woolsey, S M, Thornbury, K D, McHale, N G, Hollywood, M A

“…Rabbit urethral smooth muscle cells were studied at 37 degrees C by using the amphotericin B perforated-patch configuration of the patch-clamp technique, using…”
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T- and L-type Ca2+ Currents in Freshly Dispersed Smooth Muscle Cells from the Human Proximal Urethra by Hollywood, M. A., Woolsey, Siobhan, Walsh, I. K., Keane, P. F., McHale, N. G., Thornbury, K. D.

“…The purpose of the present study was to characterise Ca 2+ currents in smooth muscle cells isolated from biopsy samples taken from the proximal urethra of…”
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A seminal study on the mechanisms underlying spontaneous activity of the seminal vesicles? by Hollywood, M. A., Thornbury, K. D., Sergeant, G. P.

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Interstitial cells of Cajal in the urethra by Sergeant, G. P., Thornbury, K. D., McHale, N. G., Hollywood, M. A.

“…The smooth muscle layer of the urethra generates spontaneous mayogenic tone that is thougth to make a major contibution to urinary continence. The mechanisms…”
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Investigation of L-type Ca2+ current in the aganglionic bowel segment in Hirschsprung's disease by Large, R. J., Bradley, E., Webb, T., O'Donnell, A. M., Puri, P., Hollywood, M. A., Thornbury, K. D., McHale, N. G., Sergeant, G. P.

“…Background  Studies on animal models of Hirschsprung’s disease (HD) suggest that L‐type Ca2+ channels are down‐regulated in the aganglionic bowel segment,…”
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Hyperpolarisation-activated inward current in isolated sheep mesenteric lymphatic smooth muscle by McCloskey, K. D., Toland, H. M., Hollywood, M. A., Thornbury, K. D., McHale, N. G.

“…Freshly isolated sheep lymphatic smooth muscle cells were studied using the perforated patch-clamp technique. Hyperpolarisation with constant-current pulses…”
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