Search Results - "Holly, J M"

IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells by PERKS, C. M, VEMON, E. G, ROSENDAHL, A. H, TONGE, D, HOLLY, J. M. P

“…The dual-function phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is the second most frequently mutated gene in human cancers. PTEN counteracts…”
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Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2 by Biernacka, K M, Uzoh, C C, Zeng, L, Persad, R A, Bahl, A, Gillatt, D, Perks, C M, Holly, J M P

“…Clinically relevant prostate cancer (PCa) is more frequent in Westernised societies and increasingly men have co-morbidities associated with a Western…”
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The association of childhood height, leg length and other measures of skeletal growth with adult cardiovascular disease: the Boyd–Orr cohort by Whitley, E, Martin, R M, Davey Smith, G, Holly, J M P, Gunnell, D

“…BackgroundTaller adults have a reduced risk of cardiovascular disease, and there is some evidence that pre-adolescent exposures, indexed by leg length,…”
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Hyperglycaemia-induced chemoresistance in breast cancer cells: role of the estrogen receptor by Zeng, L, Zielinska, H A, Arshad, A, Shield, J P, Bahl, A, Holly, J M P, Perks, C M

“…Breast cancer patients with diabetes respond less well to chemotherapy; in keeping with this we determined previously that hyperglycaemia-induced…”
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Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase by Zeng, L, Biernacka, K M, Holly, J M P, Jarrett, C, Morrison, A A, Morgan, A, Winters, Z E, Foulstone, E J, Shield, J P, Perks, C M

“…The prognosis for women with breast cancer is adversely affected by the comorbidities of obesity and diabetes mellitus (DM), which are conditions associated…”
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Childhood dairy and calcium intake and cardiovascular mortality in adulthood: 65-year follow-up of the Boyd Orr cohort by van der Pols, J C, Gunnell, D, Williams, G M, Holly, J M P, Bain, C, Martin, R M

“…Dairy consumption in childhood may have long-term effects on cardiovascular mortality through influencing the development of risk factors or programming…”
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Insulin-like growth factor-binding protein-2 promotes prostate cancer cell growth via IGF-dependent or -independent mechanisms and reduces the efficacy of docetaxel by Uzoh, C C, Holly, J M P, Biernacka, K M, Persad, R A, Bahl, A, Gillatt, D, Perks, C M

“…Background: The development of androgen independence, chemo-, and radioresistance are critical markers of prostate cancer progression and the predominant…”
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Childhood diet and insulin-like growth factors in adulthood: 65-year follow-up of the Boyd Orr Cohort by Martin, R.M, Holly, J.M.P, Middleton, N, Smith, G.D, Gunnell, D

“…Objective: High levels of insulin-like growth factor-I (IGF-I) are associated with an increased cancer risk and reduce risk of diabetes and coronary heart…”
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Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse by Hale, LJ, Welsh, GI, Perks, CM, Hurcombe, JA, Moore, S, Hers, I, Saleem, MA, Mathieson, PW, Murphy, AJ, Jeansson, M, Holly, JM, Hardouin, SN, Coward, RJ

“…Podocytes are crucial for preventing the passage of albumin into the urine and, when lost, are associated with the development of albuminuria, renal failure…”
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Insulin-Like Growth Factor Binding Protein 3 Has Opposing Actions on Malignant and Nonmalignant Breast Epithelial Cells that Are Each Reversible and Dependent upon Cholesterol-Stabilized Integrin Receptor Complexes by Burrows, C, Holly, J. M. P, Laurence, N. J, Vernon, E. G, Carter, J. V, Clark, M. A, McIntosh, J, McCaig, C, Winters, Z. E, Perks, C. M

“…IGF-binding protein (IGFBP)-3 is generally considered to have actions that counterbalance those of IGFs and is therefore being developed as a cancer treatment…”
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Inhibition of FASN and ERα signalling during hyperglycaemia-induced matrix-specific EMT promotes breast cancer cell invasion via a caveolin-1-dependent mechanism by Zielinska, H.A., Holly, J.M.P., Bahl, A., Perks, C.M.

“…Since disturbed metabolic conditions such as obesity and diabetes can be critical determinants of breast cancer progression and therapeutic failure, we aimed…”
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Do Height-Related Variations in Insulin-Like Growth Factors Underlie the Associations of Stature with Adult Chronic Disease? by Gunnell, D., Oliver, S. E., Donovan, J. L., Peters, T. J., Gillatt, D., Persad, R., Hamdy, F. C., Neal, D. E., Holly, J. M. P.

“…Tall people, particularly those with long legs, have an increased risk of developing cancer but a reduced risk of cardiovascular disease and type II diabetes…”
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Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer? by Holly, JM, Gunnell, DJ, Davey Smith, G

“…The GH/IGF-I axis has a clearly established role in somatic growth regulation and there is much evidence suggesting that it can play a contributing role in…”
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Leg length and risk of cancer in the Boyd Orr cohort by Gunnell, D J, Davey Smith, G, Holly, J M P, Frankel, S

“…Analysis showed a significant positive association between childhood leg length and mortality from cancers unrelated to smoking…”
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Hyperglycaemia-induced resistance to Docetaxel is negated by metformin: a role for IGFBP-2 by Biernacka, K M, Persad, R A, Bahl, A, Gillatt, D, Holly, J M P, Perks, C M

“…The incidence of many common cancers varies between different populations and appears to be affected by a Western lifestyle. Highly proliferative malignant…”
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IGF1, growth pathway polymorphisms and schizophrenia: A pooling study by Gunnell, D., Lewis, S., Wilkinson, J., Georgieva, L., Davey, G. Smith, Day, I.N.M., Holly, J.M.P., O'Donovan, M.C., Owen, M.J., Kirov, G., Zammit, S.

“…It has been hypothesized that insulin‐like growth factors (IGFs) and components of the growth‐hormone (GH)‐IGF axis may underlie reported associations of poor…”
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What is the role of the insulin-like growth factor system in the pathophysiology of cancer cachexia, and how is it regulated? by Crown, A. L., Cottle, K., Lightman, S. L., Falk, S., Mohamed-Ali, V., Armstrong, L., Millar, A. B., Holly, J. M. P.

“…Summary objective and background The cancer cachexia syndrome is characterized by anorexia, weight loss with muscle wasting and increased energy expenditure…”
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Insulin-like growth factors, insulin resistance and schizophrenia by Gunnell, D, Holly, J M P

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Insulin‐like Growth Factors (IGF) I and II Utilize Different Calcium Signaling Pathways in a Primary Human Parathyroid Cell Culture Model by Wong, C. K. M., Lai, T., Holly, J. M. P., Wheeler, M. H., Stewart, C. E. H., Farndon, J. R.

“…Background In most cell types, influx of calcium (Ca2+) induces a growth or secretory response. The opposite occurs in parathyroid (PTH), cells where there is…”
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Characterisation of the IGF system in a primary adult human skeletal muscle cell model, and comparison of the effects of insulin and IGF-I on protein metabolism by Crown, AL, He, XL, Holly, JM, Lightman, SL, Stewart, CE

“…In an attempt to address the complex and clinically challenging question of the causes of muscle wasting in patients with cachexia, we have developed a primary…”
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