Search Results - "Holly, Alesia"

Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer by Reece, Kelie M, Richardson, Emily D, Cook, Kristina M, Campbell, Tessa J, Pisle, Stephen T, Holly, Alesia J, Venzon, David J, Liewehr, David J, Chau, Cindy H, Price, Douglas K, Figg, William D

“…The downstream targets of hypoxia inducible factor-1 alpha (HIF-1α) play an important role in tumor progression and angiogenesis. Therefore, inhibition of…”
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Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9 by Yu, Bing, Swatkoski, Stephen, Holly, Alesia, Lee, Liam C., Giroux, Valentin, Lee, Chih-Shia, Hsu, Dennis, Jordan, L. Smith, Yuen, Garmen, Yue, Junqiu, Ann, David K., Simpson, R. Mark, Creighton, Chad J., Figg, William D., Gucek, Marjan, Luo, Ji

“…Significance Currently there are no targeted therapies for KRAS mutant cancer. Our study uncovers a critical role of the small ubiquitin-like modifier (SUMO)…”
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Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats by Peer, Cody J, Strope, Jonathan D, Beedie, Shaunna, Ley, Ariel M, Holly, Alesia, Calis, Karim, Farkas, Ronald, Parepally, Jagan, Men, Angela, Fadiran, Emmanuel O, Scott, Pamela, Jenkins, Marjorie, Theodore, William H, Sissung, Tristan M

“…The recommended zolpidem starting dose was lowered in females (5 mg vs. 10 mg) since side effects were more frequent and severe than those of males; the…”
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Polylactide-based paclitaxel-loaded nanoparticles fabricated by dispersion polymerization: characterization, evaluation in cancer cell lines, and preliminary biodistribution studies by Adesina, Simeon K, Holly, Alesia, Kramer-Marek, Gabriela, Capala, Jacek, Akala, Emmanuel O

“…The macromonomer method was used to prepare cross-linked, paclitaxel-loaded polylactide (PLA)-polyethylene glycol (stealth) nanoparticles using free-radical…”
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Abstract B29: A critical role of the SUMO pathway in KRAS-driven oncogenesis by Yu, Bing, Swatkoski, Steve, Holly, Alesia, Lee, Liam Changwoo, Giroux, Valentin, Lee, Chih-Shia, Carver, Joseph, Creighton, Chad, Ann, David K., Figg, William Douglas, Gucek, Marjan, Luo, Ji

“…Abstract The SUMOylation pathway modulates the activity of many cellular proteins and plays an important role in cellular stress protection. We identified the…”
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Disruption of the HIF‐1α/p300 interaction as a means of inhibiting angiogenesis by Reece, Kelie M, Richardson, Emily D, Pisle, Stephen T, Holly, Alesia J, Campbell, Tessa J, Figg, William D

“…Abstract only Solid tumors develop regions of hypoxia because of an imbalance in oxygen supply and consumption. Thus, adaptation of cancer cells to hypoxia is…”
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Epidithiodiketopiperazines exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1[alpha]/p300 complex in a preclinical model of prostate cancer by Reece, Kelie M, Richardson, Emily D, Cook, Kristina M, Campbell, Tessa J, Pisle, Stephen T, Holly, Alesia J, Venzon, David J, Liewehr, David J, Chau, Cindy H, Price, Douglas K, Figg, William D

“…The downstream targets of hypoxia inducible factor-1 alpha (HIF-1[alpha]) play an important role in tumor progression and angiogenesis. Therefore, inhibition…”
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Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N′-nitro-N-nitrosoguanidine and promoted by mezerein by Rehman, Ishtiaq, Lowry, David T., Adams, Cameron, Abdel-Fattah, Rana, Holly, Alesia, Yuspa, Stuart H., Hennings, Henry

“…The skin tumor initiators N‐methy‐N′‐nitro‐N‐nitrosoguanidine (MNNG) and 7,12‐dimethylbenz[a]anthracene (DMBA) differ in effectiveness when tumor formation is…”
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Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated byN-methyl-N?-nitro-N-nitrosoguanidine and promoted by mezerein by Rehman, Ishtiaq, Lowry, David T., Adams, Cameron, Abdel-Fattah, Rana, Holly, Alesia, Yuspa, Stuart H., Hennings, Henry

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