Search Results - "Holloway, Harold W."

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism by Li, Yazhou, Perry, TracyAnn, Kindy, Mark S, Harvey, Brandon K, Tweedie, David, Holloway, Harold W, Powers, Kathleen, Shen, Hui, Egan, Josephine M, Sambamurti, Kumar, Brossi, Arnold, Lahiri, Debomoy K, Mattson, Mark P, Hoffer, Barry J, Wang, Yun, Greig, Nigel H

“…Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the gastrointestinal tract in response to food intake. It enhances…”
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Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells by Li, Yazhou, Tweedie, David, Mattson, Mark P, Holloway, Harold W, Greig, Nigel H

“…J. Neurochem. (2010) 113, 1621-1631. Increasing evidence suggests that glucagon-like peptide-1 (GLP-1), an incretin hormone of current interest in type 2…”
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Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease by Tweedie, David, Ferguson, Ryan A, Fishman, Kelly, Frankola, Kathryn A, Van Praag, Henriette, Holloway, Harold W, Luo, Weiming, Li, Yazhou, Caracciolo, Luca, Russo, Isabella, Barlati, Sergio, Ray, Balmiki, Lahiri, Debomoy K, Bosetti, Francesca, Greig, Nigel H, Rosi, Susanna

“…Neuroinflammation is associated with virtually all major neurodegenerative disorders, including Alzheimer's disease (AD). Although it remains unclear whether…”
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Selective Butyrylcholinesterase Inhibition Elevates Brain Acetylcholine, Augments Learning and Lowers Alzheimer β-Amyloid Peptide in Rodent by Greig, Nigel H., Utsuki, Tadanobu, Ingram, Donald K., Wang, Yue, Pepeu, Giancarlo, Carla Scali, Yu, Qian-Sheng, Jacek Mamczarz, Harold W. Holloway, Tony Giordano, De Mao Chen, Furukawa, Katsutoshi, Sambamurti, Kumar, Brossi, Arnold, Lahiri, Debomoy K.

“…Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter acetylcholine (ACh) and is hence a viable therapeutic target in…”
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Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis by Li, Yazhou, Chigurupati, Srinivasulu, Holloway, Harold W, Mughal, Mohamed, Tweedie, David, Bruestle, Daniel A, Mattson, Mark P, Wang, Yun, Harvey, Brandon K, Ray, Balmiki, Lahiri, Debomoy K, Greig, Nigel H

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by a progressive loss of lower motor neurons in the spinal cord…”
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Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration by Rachmany, Lital, Tweedie, David, Rubovitch, Vardit, Li, Yazhou, Holloway, Harold W., Kim, Dong Seok, Ratliff, Whitney A., Saykally, Jessica N., Citron, Bruce A., Hoffer, Barry J., Greig, Nigel H., Pick, Chaim G.

“…Mild blast traumatic brain injury (B-TBI) induced lasting cognitive impairments in novel object recognition and less severe deficits in Y-maze behaviors. B-TBI…”
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Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy by Perry, TracyAnn, Holloway, Harold W., Weerasuriya, Ananda, Mouton, Peter R., Duffy, Kara, Mattison, Julie A., Greig, Nigel H.

“…Pyridoxine (vitamin B6) intoxicated rodents develop a peripheral neuropathy characterized by sensory nerve conduction deficits associated with disturbances of…”
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Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms by Tweedie, David, Fukui, Koji, Li, Yazhou, Yu, Qian-Sheng, Barak, Shani, Tamargo, Ian A, Rubovitch, Vardit, Holloway, Harold W, Lehrmann, Elin, Wood, 3rd, William H, Zhang, Yongqing, Becker, Kevin G, Perez, Evelyn, Van Praag, Henriette, Luo, Yu, Hoffer, Barry J, Becker, Robert E, Pick, Chaim G, Greig, Nigel H

“…Traumatic brain injury (TBI), often caused by a concussive impact to the head, affects an estimated 1.7 million Americans annually. With no approved drugs, its…”
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Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats by Szayna, Margarzata, Doyle, Máire E, Betkey, Jennifer A, Holloway, Harold W, Spencer, Richard G. S, Greig, Nigel H, Egan, Josephine M

“…Exendin-4 is a 39 amino acid peptide produced in the salivary gland of the Gila monster lizard. It has a 53% amino acid homology to the incretin hormone…”
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A new therapeutic target in Alzheimer's disease treatment: Attention to butyrylcholinesterase by GREIG, Nigel H, UTSUKI, Tada, YU, Qian-Sheng, XIAOXIANG ZHU, HOLLOWAY, Harold W, PERRY, Tracyann, BONG LEE, INGRAM, Donald K, LAHIRI, Debomoy K

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly, characterised by widespread loss of central cholinergic function. The only…”
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Kinetics of Human Serum Butyrylcholinesterase Inhibition by a Novel Experimental Alzheimer Therapeutic, Dihydrobenzodioxepine Cymserine by Kamal, Mohammad A., Klein, Peter, Luo, Weiming, Li, Yazhou, Holloway, Harold W., Tweedie, David, Greig, Nigel H.

“…Cholinergic loss is the single most replicated neurotransmitter deficiency in Alzheimer’s disease (AD) and has led to the use of acetylcholinesterase…”
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Inhibition of Human Acetyl- and Butyrylcholinesterase by Novel Carbamates of (−)- and (+)-Tetrahydrofurobenzofuran and Methanobenzodioxepine by Luo, Weiming, Yu, Qian-sheng, Kulkarni, Santosh S, Parrish, Damon A, Holloway, Harold W, Tweedie, David, Shafferman, Avigdor, Lahiri, Debomoy K, Brossi, Arnold, Greig, Nigel H

“…A new enantiomeric synthesis utilizing classical resolution provided two novel series of optically active inhibitors of cholinesterase:  (−)- and…”
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Synthesis of Novel Phenserine-Based-Selective Inhibitors of Butyrylcholinesterase for Alzheimer's Disease by Yu, Qian-sheng, Holloway, Harold W, Utsuki, Tadanobu, Brossi, Arnold, Greig, Nigel H

“…Four novel analogues (8 − 11) of cymserine (2) were synthesized by methods similar to those recently developed for the total syntheses of N 8-norphenserine…”
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Development of Molecular Probes for the Identification of Extra Interaction Sites in the Mid-Gorge and Peripheral Sites of Butyrylcholinesterase (BuChE). Rational Design of Novel, Selective, and Highly Potent BuChE Inhibitors by Campiani, Giuseppe, Fattorusso, Caterina, Butini, Stefania, Gaeta, Alessandra, Agnusdei, Marianna, Gemma, Sandra, Persico, Marco, Catalanotti, Bruno, Savini, Luisa, Nacci, Vito, Novellino, Ettore, Holloway, Harold W, Greig, Nigel H, Belinskaya, Tatyana, Fedorko, James M, Saxena, Ashima

“…Tacrine heterobivalent ligands were designed as novel and reversible inhibitors of cholinesterases. On the basis of the investigation of the active site gorge…”
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A synthetic uric acid analog accelerates cutaneous wound healing in mice by Chigurupati, Srinivasulu, Mughal, Mohamed R, Chan, Sic L, Arumugam, Thiruma V, Baharani, Akanksha, Tang, Sung-Chun, Yu, Qian-Sheng, Holloway, Harold W, Wheeler, Ross, Poosala, Suresh, Greig, Nigel H, Mattson, Mark P

“…Wound healing is a complex process involving intrinsic dermal and epidermal cells, and infiltrating macrophages and leukocytes. Excessive oxidative stress and…”
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Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy by Perry, Tracy Ann, Weerasuriya, Ananda, Mouton, Peter R., Holloway, Harold W., Greig, Nigel H.

“…Excess ingestion of pyridoxine (vitamin B6) causes a severe sensory neuropathy in humans. The mechanism of action has not been fully elucidated, and studies of…”
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GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease by Li, Yazhou, Duffy, Kara B, Ottinger, Mary Ann, Ray, Balmiki, Bailey, Jason A, Holloway, Harold W, Tweedie, David, Perry, Tracyann, Mattson, Mark P, Kapogiannis, Dimitrios, Sambamurti, Kumar, Lahiri, Debomoy K, Greig, Nigel H

“…Type 2 (T2) diabetes mellitus (DM) has been associated with an increased incidence of neurodegenerative disorders, including Alzheimer's disease (AD). Several…”
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Anticholinesterase Activity of Compounds Related to Geneserine Tautomers. N-Oxides and 1,2-Oxazines by Yu, Qian-sheng, Zhu, Xiaoxiang, Holloway, Harold W, Whittaker, Noel F, Brossi, Arnold, Greig, Nigel H

“…A series of phenylcarbamate analogues of geneserine (8, 10, 12, 14) were synthesized from their counterparts, the phenylcarbamate analogues of physostigmine…”
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Blast traumatic brain injury–induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4 by Tweedie, David, Rachmany, Lital, Rubovitch, Vardit, Li, Yazhou, Holloway, Harold W, Lehrmann, Elin, Zhang, Yongqing, Becker, Kevin G, Perez, Evelyn, Hoffer, Barry J, Pick, Chaim G, Greig, Nigel H

“…Abstract Introduction Blast traumatic brain injury (B-TBI) affects military and civilian personnel. Presently, there are no approved drugs for blast brain…”
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Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy by Utsuki, Tadanobu, Uchimura, Nao, Irikura, Mitsuru, Moriuchi, Hiroshi, Holloway, Harold W, Yu, Qian-Sheng, Spangler, Edward L, Mamczarz, Jacek, Ingram, Donald K, Irie, Tetsumi, Greig, Nigel H

“…Phenserine (PS) was designed as a selective acetylcholinesterase (AChE) inhibitor, with a tartrate form (PST) for oral administration in mild to moderate…”
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