Search Results - "Holloway, Alison"
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Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production
Published in Canadian journal of physiology and pharmacology (01-09-2021)“…Fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor antidepressant, has been shown to increase hepatic lipid accumulation, a key factor in…”
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2
Fluoxetine‐induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15‐deoxy‐Δ12,14PGJ2
Published in Journal of applied toxicology (01-06-2022)“…Major depressive disorder and other neuropsychiatric disorders are often managed with long‐term use of antidepressant medication. Fluoxetine, an SSRI…”
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3
A risk of bias instrument for non-randomized studies of exposures: A users' guide to its application in the context of GRADE
Published in Environment international (01-01-2019)“…The objective of this paper is to explain how to apply, interpret, and present the results of a new instrument to assess the risk of bias (RoB) in…”
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Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta
Published in Scientific reports (17-01-2020)“…1 in 5 women report cannabis use during pregnancy, with nausea cited as their primary motivation. Studies show that (-)-△9–tetrahydrocannabinol (Δ9-THC ), the…”
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Early Life Exposure to Nicotine: Postnatal Metabolic, Neurobehavioral and Respiratory Outcomes and the Development of Childhood Cancers
Published in Toxicological sciences (01-11-2020)“…Abstract Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal, and developmental complications, as well as an increased risk of…”
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Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review
Published in Toxicological sciences (01-08-2010)“…Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal, and developmental complications, as well as an increased risk of adverse…”
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7
Fluoxetine-induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15-deoxy-Δ 12,14 PGJ 2
Published in Journal of applied toxicology (01-06-2022)“…Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI…”
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8
GRADE: Assessing the quality of evidence in environmental and occupational health
Published in Environment international (01-07-2016)“…There is high demand in environmental health for adoption of a structured process that evaluates and integrates evidence while making decisions and…”
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Δ9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts
Published in Reproductive toxicology (Elmsford, N.Y.) (01-08-2019)“…•Δ9-tetrahydrocannabinol directly induces endoplasmic stress in placental BeWo cells.•This helps elucidate why Δ9-tetrahydrocannabinol in vivo leads to…”
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10
Impact of pesticide exposure on adipose tissue development and function
Published in Biochemical journal (31-07-2020)“…Obesity is a leading cause of morbidity, mortality and health care expenditure whose incidence is rapidly rising across the globe. Although the cause of the…”
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Excess feeding increases adipogenesis but lowers leptin transcript abundance in zebrafish larvae
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-02-2024)“…Although fish exposed to municipal wastewater effluents (MWWE) show higher lipid accumulation, whether this is due to adipogenesis is unclear. The objective…”
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Maternal exposure to Δ9-tetrahydrocannabinol impairs female offspring glucose homeostasis and endocrine pancreatic development in the rat
Published in Reproductive toxicology (Elmsford, N.Y.) (01-06-2020)“…•Fetal exposure to Δ9-THC causes female-specific glucose intolerance in adulthood.•This glucose intolerance is associated with impaired insulin sensitivity in…”
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Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
Published in BioMed research international (01-01-2015)“…Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy…”
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The effects of electronic cigarette vapor on placental trophoblast cell function
Published in Reproductive toxicology (Elmsford, N.Y.) (01-10-2018)“…•E-cigarette use is increasing rapidly yet there is limited data available regarding its effects during pregnancy.•E-cigarette conditioned-media impaired…”
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Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice
Published in Nature communications (20-12-2022)“…Chemicals in food are widely used leading to significant human exposure. Allura Red AC (AR) is a highly common synthetic colorant; however, little is known…”
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An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway
Published in International journal of molecular sciences (04-06-2022)“…Tryptophan (TRP) is an essential dietary amino acid that, unless otherwise committed to protein synthesis, undergoes metabolism via the Tryptophan-Kynurenine…”
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Adverse fetal and neonatal outcomes associated with a life-long high fat diet: role of altered development of the placental vasculature
Published in PloS one (19-03-2012)“…Maternal obesity results in a number of obstetrical and fetal complications with both immediate and long-term consequences. The increased prevalence of obesity…”
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The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue
Published in Nature communications (27-08-2021)“…Obesity results from a caloric imbalance between energy intake, absorption and expenditure. In both rodents and humans, diet-induced thermogenesis contributes…”
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The role of the endocannabinoid system in female reproductive tissues
Published in Journal of ovarian research (15-01-2019)“…There has been increasing interest in the role of endocannabinoids as critical modulators of the female reproductive processes. Endocannabinoids are natural…”
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Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants
Published in Scientific reports (28-11-2017)“…Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout…”
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