Search Results - "Hollmann, Claudia"
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Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction
Published in PloS one (16-04-2020)“…Both conventional and regulatory CD4+ T-cells rely on costimulatory signals mediated by cell surface receptors including CD28 for full activation. We showed…”
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Correction: Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction
Published in PloS one (06-07-2020)“…[This corrects the article DOI: 10.1371/journal.pone.0227734.]…”
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3
Acid ceramidase expression reduces IFNγ secretion by mouse CD4 + T cells and is crucial for maintaining B-cell numbers in mice
Published in Frontiers in immunology (2024)“…Acid ceramidase (Ac) is a lysosomal enzyme catalyzing the generation of sphingosine from ceramide, and Ac inhibitors are currently being investigated as…”
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Translational Approaches Targeting Ceramide Generation From Sphingomyelin in T Cells to Modulate Immunity in Humans
Published in Frontiers in immunology (11-10-2019)“…In T cells, as in all other cells of the body, sphingolipids form important structural components of membranes. Due to metabolic modifications, sphingolipids…”
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Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations
Published in Journal of functional biomaterials (02-08-2022)“…A fine balance of regulatory (Treg) and conventional CD4+ T cells (Tconv) is required to prevent harmful immune responses, while at the same time ensuring the…”
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CSF-1-activated macrophages are target-directed and essential mediators of schwann cell dedifferentiation and dysfunction in Cx32-deficient mice
Published in Glia (01-06-2015)“…We investigated connexin 32 (Cx32)‐deficient mice, a model for the X‐linked form of Charcot‐Marie‐Tooth neuropathy (CMT1X), regarding the impact of low‐grade…”
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Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells
Published in The Journal of immunology (1950) (15-10-2016)“…CD4 Foxp3 regulatory T cells (Tregs) depend on CD28 signaling for their survival and function, a receptor that has been previously shown to activate the acid…”
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Role of CD4+ T-cells for regulating splenic myelopoiesis and monocyte differentiation after experimental myocardial infarction
Published in Basic research in cardiology (01-04-2024)“…Myocardial infarction (MI) induces the generation of proinflammatory Ly6C high monocytes in the spleen and the recruitment of these cells to the myocardium…”
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CSF ‐1‐activated macrophages are target‐directed and essential mediators of schwann cell dedifferentiation and dysfunction in C x32‐deficient mice
Published in Glia (01-06-2015)“…We investigated connexin 32 (Cx32)‐deficient mice, a model for the X‐linked form of Charcot‐Marie‐Tooth neuropathy (CMT1X), regarding the impact of low‐grade…”
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Journal Article -
10
Inhibition of acid sphingomyelinase increases regulatory T cells in humans
Published in Brain communications (01-01-2021)“…Abstract Genetic deficiency for acid sphingomyelinase or its pharmacological inhibition has been shown to increase Foxp3+ regulatory T-cell frequencies among…”
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11
A cognitive human behaviour model for pedestrian behaviour simulation
Published 01-01-2015“…Pedestrian behaviour simulation models are being developed with the intention to simulate human behaviour in various environments in both non-emergency and…”
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Dissertation