Search Results - "Hollmann, Claudia"

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    Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction by Gladow, Nadine, Hollmann, Claudia, Ramos, Gustavo, Frantz, Stefan, Kerkau, Thomas, Beyersdorf, Niklas, Hofmann, Ulrich

    Published in PloS one (16-04-2020)
    “…Both conventional and regulatory CD4+ T-cells rely on costimulatory signals mediated by cell surface receptors including CD28 for full activation. We showed…”
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    Journal Article
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    Acid ceramidase expression reduces IFNγ secretion by mouse CD4 + T cells and is crucial for maintaining B-cell numbers in mice by Mandasari, Putri, Hollmann, Claudia, Zaidi, Rehan-Haider, Löw, Samira, Schrama, Jann, Wigger, Dominik, Schumacher, Fabian, Kleuser, Burkhard, Beyersdorf, Niklas

    Published in Frontiers in immunology (2024)
    “…Acid ceramidase (Ac) is a lysosomal enzyme catalyzing the generation of sphingosine from ceramide, and Ac inhibitors are currently being investigated as…”
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    Journal Article
  4. 4

    Translational Approaches Targeting Ceramide Generation From Sphingomyelin in T Cells to Modulate Immunity in Humans by Hollmann, Claudia, Wiese, Teresa, Dennstädt, Fabio, Fink, Julian, Schneider-Schaulies, Jürgen, Beyersdorf, Niklas

    Published in Frontiers in immunology (11-10-2019)
    “…In T cells, as in all other cells of the body, sphingolipids form important structural components of membranes. Due to metabolic modifications, sphingolipids…”
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    Journal Article
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    CSF-1-activated macrophages are target-directed and essential mediators of schwann cell dedifferentiation and dysfunction in Cx32-deficient mice by Groh, Janos, Klein, Ines, Hollmann, Claudia, Wettmarshausen, Jennifer, Klein, Dennis, Martini, Rudolf

    Published in Glia (01-06-2015)
    “…We investigated connexin 32 (Cx32)‐deficient mice, a model for the X‐linked form of Charcot‐Marie‐Tooth neuropathy (CMT1X), regarding the impact of low‐grade…”
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    Journal Article
  7. 7

    Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells by Hollmann, Claudia, Werner, Sandra, Avota, Elita, Reuter, Dajana, Japtok, Lukasz, Kleuser, Burkhard, Gulbins, Erich, Becker, Katrin Anne, Schneider-Schaulies, Jürgen, Beyersdorf, Niklas

    Published in The Journal of immunology (1950) (15-10-2016)
    “…CD4 Foxp3 regulatory T cells (Tregs) depend on CD28 signaling for their survival and function, a receptor that has been previously shown to activate the acid…”
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    Journal Article
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    CSF ‐1‐activated macrophages are target‐directed and essential mediators of schwann cell dedifferentiation and dysfunction in C x32‐deficient mice by Groh, Janos, Klein, Ines, Hollmann, Claudia, Wettmarshausen, Jennifer, Klein, Dennis, Martini, Rudolf

    Published in Glia (01-06-2015)
    “…We investigated connexin 32 (Cx32)‐deficient mice, a model for the X‐linked form of Charcot‐Marie‐Tooth neuropathy (CMT1X), regarding the impact of low‐grade…”
    Get full text
    Journal Article
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    A cognitive human behaviour model for pedestrian behaviour simulation by Hollmann, Claudia

    Published 01-01-2015
    “…Pedestrian behaviour simulation models are being developed with the intention to simulate human behaviour in various environments in both non-emergency and…”
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    Dissertation