Search Results - "Hollingsworth, Michael"

Inflammatory and immune effects on tumor progression by Mehla, Kamiya, Hollingsworth, Michael A.

“…Tumor progression is known occur in a complex microenvironment that leads to genetic, cellular, and metabolic adaptations. Two articles from Martin et al. and…”
Get full text

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver by Costa-Silva, Bruno, Aiello, Nicole M., Ocean, Allyson J., Singh, Swarnima, Zhang, Haiying, Thakur, Basant Kumar, Becker, Annette, Hoshino, Ayuko, Mark, Milica Tešić, Molina, Henrik, Xiang, Jenny, Zhang, Tuo, Theilen, Till-Martin, García-Santos, Guillermo, Williams, Caitlin, Ararso, Yonathan, Huang, Yujie, Rodrigues, Gonçalo, Shen, Tang-Long, Labori, Knut Jørgen, Lothe, Inger Marie Bowitz, Kure, Elin H., Hernandez, Jonathan, Doussot, Alexandre, Ebbesen, Saya H., Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Schwartz, Robert E., Matei, Irina, Peinado, Héctor, Stanger, Ben Z., Bromberg, Jacqueline, Lyden, David

“…Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular…”
Get full text

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy by Sleightholm, Richard L, Neilsen, Beth K, Li, Jing, Steele, Maria M, Singh, Rakesh K, Hollingsworth, Michael A, Oupicky, David

“…Chemokine networks regulate a variety of cellular, physiological, and immune processes. These normal functions can become appropriated by cancer cells to…”
Get full text

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis by Roe, Jae-Seok, Hwang, Chang-Il, Somerville, Tim D.D., Milazzo, Joseph P., Lee, Eun Jung, Da Silva, Brandon, Maiorino, Laura, Tiriac, Hervé, Young, C. Megan, Miyabayashi, Koji, Filippini, Dea, Creighton, Brianna, Burkhart, Richard A., Buscaglia, Jonathan M., Kim, Edward J., Grem, Jean L., Lazenby, Audrey J., Grunkemeyer, James A., Hollingsworth, Michael A., Grandgenett, Paul M., Egeblad, Mikala, Park, Youngkyu, Tuveson, David A., Vakoc, Christopher R.

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid…”
Get full text

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma by Moffitt, Richard A, Marayati, Raoud, Flate, Elizabeth L, Volmar, Keith E, Loeza, S Gabriela Herrera, Hoadley, Katherine A, Rashid, Naim U, Williams, Lindsay A, Eaton, Samuel C, Chung, Alexander H, Smyla, Jadwiga K, Anderson, Judy M, Kim, Hong Jin, Bentrem, David J, Talamonti, Mark S, Iacobuzio-Donahue, Christine A, Hollingsworth, Michael A, Yeh, Jen Jen

“…Jen Jen Yeh and colleagues apply statistical methods to separate tumor, stroma and normal tissue gene expression signatures from pancreatic ductal…”
Get full text

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle by Wang, Gang, Biswas, Anup K., Ma, Wanchao, Kandpal, Manoj, Coker, Courtney, Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Rinku, Tanji, Kurenai, Lόpez-Pintado, Sara, Borczuk, Alain, Hebert, Doreen, Jenkitkasemwong, Supak, Hojyo, Shintaro, Davuluri, Ramana V., Knutson, Mitchell D., Fukada, Toshiyuki, Acharyya, Swarnali

“…Patients with metastatic cancer experience a severe loss of skeletal muscle mass and function known as cachexia. Cachexia is associated with poor prognosis and…”
Get full text

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling) by Hanson, Ryan L, Hollingsworth, Michael A

“…Glycosylation is one of the most abundant post-translational modifications that occur within the cell. Under normal physiological conditions, O-linked…”
Get full text

Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning by Yokoyama, Seiya, Hamada, Taiji, Higashi, Michiyo, Matsuo, Kei, Maemura, Kosei, Kurahara, Hiroshi, Horinouchi, Michiko, Hiraki, Tsubasa, Sugimoto, Tomoyuki, Akahane, Toshiaki, Yonezawa, Suguru, Kornmann, Marko, Batra, Surinder K, Hollingsworth, Michael A, Tanimoto, Akihide

“…Pancreatic cancer remains a disease of high mortality despite advanced diagnostic techniques. Mucins (MUC) play crucial roles in carcinogenesis and tumor…”
Get full text

Cell surface-associated mucins in signal transduction by Singh, Pankaj K., Hollingsworth, Michael A.

“…Mucins are heavily glycosylated high molecular weight glycoproteins, which are involved in the protection and lubrication of luminal epithelial surfaces…”
Get full text

Tumour exosome integrins determine organotropic metastasis by Hoshino, Ayuko, Costa-Silva, Bruno, Shen, Tang-Long, Rodrigues, Goncalo, Hashimoto, Ayako, Tesic Mark, Milica, Molina, Henrik, Kohsaka, Shinji, Di Giannatale, Angela, Ceder, Sophia, Singh, Swarnima, Williams, Caitlin, Soplop, Nadine, Uryu, Kunihiro, Pharmer, Lindsay, King, Tari, Bojmar, Linda, Davies, Alexander E., Ararso, Yonathan, Zhang, Tuo, Zhang, Haiying, Hernandez, Jonathan, Weiss, Joshua M., Dumont-Cole, Vanessa D., Kramer, Kimberly, Wexler, Leonard H., Narendran, Aru, Schwartz, Gary K., Healey, John H., Sandstrom, Per, Jørgen Labori, Knut, Kure, Elin H., Grandgenett, Paul M., Hollingsworth, Michael A., de Sousa, Maria, Kaur, Sukhwinder, Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Brady, Mary S., Fodstad, Oystein, Muller, Volkmar, Pantel, Klaus, Minn, Andy J., Bissell, Mina J., Garcia, Benjamin A., Kang, Yibin, Rajasekhar, Vinagolu K., Ghajar, Cyrus M., Matei, Irina, Peinado, Hector, Bromberg, Jacqueline, Lyden, David

“…Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from…”
Get full text

An intravenous pancreatic cancer therapeutic: Characterization of CRISPR/Cas9n-modified Clostridium novyi-Non Toxic by Dailey, Kaitlin M, Small, James M, Pullan, Jessica E, Winfree, Seth, Vance, Krysten E, Orr, Megan, Mallik, Sanku, Bayles, Kenneth W, Hollingsworth, Michael A, Brooks, Amanda E

“…Clostridium novyi has demonstrated selective efficacy against solid tumors largely due to the microenvironment contained within dense tumor cores. The core of…”
Get full text

Invasive phenotype induced by low extracellular pH requires mitochondria dependent metabolic flexibility by Shin, Simon C., Thomas, Divya, Radhakrishnan, Prakash, Hollingsworth, Michael A.

“…Metabolic reprogramming is required for tumors to meet the bioenergetic and biosynthetic demands of malignant progression. Numerous studies have established a…”
Get full text

Immature truncated O-glycophenotype of cancer directly induces oncogenic features by Radhakrishnan, Prakash, Dabelsteen, Sally, Madsen, Frey Brus, Francavilla, Chiara, Kopp, Katharina L, Steentoft, Catharina, Vakhrushev, Sergey Y, Olsen, Jesper V, Hansen, Lars, Bennett, Eric P, Woetmann, Anders, Yin, Guangliang, Chen, Longyun, Song, Haiyan, Bak, Mads, Hlady, Ryan A, Peters, Staci L, Opavsky, Rene, Thode, Christenze, Qvortrup, Klaus, Schjoldager, Katrine T-B G, Clausen, Henrik, Hollingsworth, Michael A, Wandall, Hans H

“…Aberrant expression of immature truncated O-glycans is a characteristic feature observed on virtually all epithelial cancer cells, and a very high frequency is…”
Get full text

Pathobiological implications of MUC16 expression in pancreatic cancer by Haridas, Dhanya, Chakraborty, Subhankar, Ponnusamy, Moorthy P, Lakshmanan, Imayavaramban, Rachagani, Satyanarayana, Cruz, Eric, Kumar, Sushil, Das, Srustidhar, Lele, Subodh M, Anderson, Judy M, Wittel, Uwe A, Hollingsworth, Michael A, Batra, Surinder K

“…MUC16 (CA125) belongs to a family of high-molecular weight O-glycosylated proteins known as mucins. While MUC16 is well known as a biomarker in ovarian cancer,…”
Get full text

A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study by Kaur, Sukhwinder, Smith, Lynette M, Patel, Asish, Menning, Melanie, Watley, Duncan C, Malik, Saad S, Krishn, Shiv Ram, Mallya, Kavita, Aithal, Abhijit, Sasson, Aaron R, Johansson, Sonny L, Jain, Maneesh, Singh, Shailender, Guha, Sushovan, Are, Chandrakanth, Raimondo, Massimo, Hollingsworth, Michael A, Brand, Randall E, Batra, Surinder K

“…Pancreatic cancer (PC) is a lethal malignancy that lacks specific diagnostic markers. The present study explores the diagnostic potential of the most…”
Get full text

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer by BAILEY, Jennifer M, SWANSON, Benjamin J, HAMADA, Tomofumi, EGGERS, John P, SINGH, Pankaj K, CAFFERY, Thomas, OUELLETTE, Michel M, HOLLINGSWORTH, Michael A

“…Purpose: We investigated the contribution of Sonic hedgehog (SHH) to pancreatic cancer progression. Experimental Design: We expressed SHH in a transformed…”
Get full text

Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma by Chaika, Nina V, Yu, Fang, Purohit, Vinee, Mehla, Kamiya, Lazenby, Audrey J, DiMaio, Dominick, Anderson, Judy M, Yeh, Jen Jen, Johnson, Keith R, Hollingsworth, Michael A, Singh, Pankaj K

“…Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a five-year survival rate of 6%. It is characterized by…”
Get full text

Tumour extracellular vesicles and particles induce liver metabolic dysfunction by Wang, Gang, Li, Jianlong, Bojmar, Linda, Chen, Haiyan, Li, Zhong, Tobias, Gabriel C., Hu, Mengying, Homan, Edwin A., Lucotti, Serena, Zhao, Fengbo, Posada, Valentina, Oxley, Peter R., Cioffi, Michele, Kim, Han Sang, Wang, Huajuan, Lauritzen, Pernille, Boudreau, Nancy, Shi, Zhanjun, Burd, Christin E., Zippin, Jonathan H., Lo, James C., Pitt, Geoffrey S., Hernandez, Jonathan, Zambirinis, Constantinos P., Hollingsworth, Michael A., Grandgenett, Paul M., Jain, Maneesh, Batra, Surinder K., DiMaio, Dominick J., Grem, Jean L., Klute, Kelsey A., Trippett, Tanya M., Egeblad, Mikala, Paul, Doru, Bromberg, Jacqueline, Kelsen, David, Rajasekhar, Vinagolu K., Healey, John H., Matei, Irina R., Jarnagin, William R., Schwartz, Robert E., Zhang, Haiying, Lyden, David

“…Cancer alters the function of multiple organs beyond those targeted by metastasis 1 , 2 . Here we show that inflammation, fatty liver and dysregulated…”
Get full text

Intracellular CD24 Inhibits Cell Invasion by Posttranscriptional Regulation of BART through Interaction with G3BP by TANIUCHI, Keisuke, NISHIMORI, Isao, HOLLINGSWORTH, Michael A

“…We report a novel function for the CD24 molecule in pancreatic cancer cells. Intracellular CD24 is associated with stress granules that contain specific mRNAs…”
Get full text

Mucins in cancer: protection and control of the cell surface by Hollingsworth, Michael A, Swanson, Benjamin J

“…Mucins -- large extracellular proteins that are heavily glycosylated with complex oligosaccharides -- establish a selective molecular barrier at the epithelial…”
Get full text