Search Results - "Holley, Scott A"

Integration of cell–cell and cell–ECM adhesion in vertebrate morphogenesis by McMillen, Patrick, Holley, Scott A

“…In this review, we highlight recent re-evaluations of the classical cell sorting models and their application to understanding embryonic morphogenesis. Modern…”
Get full text

Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics by Dray, Nicolas, Lawton, Andrew, Nandi, Amitabha, Jülich, Dörthe, Emonet, Thierry, Holley, Scott A.

“…During embryonic development and tissue homeostasis, cells produce and remodel the extracellular matrix (ECM). The ECM maintains tissue integrity and can serve…”
Get full text

Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins by Neklesa, Taavi K, Tae, Hyun Seop, Schneekloth, Ashley R, Stulberg, Michael J, Corson, Timothy W, Sundberg, Thomas B, Raina, Kanak, Holley, Scott A, Crews, Craig M

“…A search through hydrophobic chemical space identifies an adamantane tag that targets dehalogenase fusion proteins for degradation, as demonstrated for both…”
Get full text

The genetics and embryology of zebrafish metamerism by Holley, Scott A.

“…Somites are the most obvious metameric structures in the vertebrate embryo. They are mesodermal segments that form in bilateral pairs flanking the notochord…”
Get full text

Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology by Jülich, Dörthe, Cobb, Garrett, Melo, Ana M., McMillen, Patrick, Lawton, Andrew K., Mochrie, Simon G.J., Rhoades, Elizabeth, Holley, Scott A.

“…The diverse morphologies of animal tissues are underlain by different configurations of adherent cells and extracellular matrix (ECM). Here, we elucidate…”
Get full text

Organization of Embryonic Morphogenesis via Mechanical Information by Das, Dipjyoti, Jülich, Dörthe, Schwendinger-Schreck, Jamie, Guillon, Emilie, Lawton, Andrew K., Dray, Nicolas, Emonet, Thierry, O’Hern, Corey S., Shattuck, Mark D., Holley, Scott A.

“…Embryonic organizers establish gradients of diffusible signaling molecules to pattern the surrounding cells. Here, we elucidate an additional mechanism of…”
Get full text

Regulated tissue fluidity steers zebrafish body elongation by Lawton, Andrew K, Nandi, Amitabha, Stulberg, Michael J, Dray, Nicolas, Sneddon, Michael W, Pontius, William, Emonet, Thierry, Holley, Scott A

“…The tailbud is the posterior leading edge of the growing vertebrate embryo and consists of motile progenitors of the axial skeleton, musculature and spinal…”
Get full text

Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi by Yaganoglu, Sine, Kalyviotis, Konstantinos, Vagena-Pantoula, Christina, Jülich, Dörthe, Gaub, Benjamin M., Welling, Maaike, Lopes, Tatiana, Lachowski, Dariusz, Tang, See Swee, Del Rio Hernandez, Armando, Salem, Victoria, Müller, Daniel J., Holley, Scott A., Vermot, Julien, Shi, Jian, Helassa, Nordine, Török, Katalin, Pantazis, Periklis

“…Mechanosensing is a ubiquitous process to translate external mechanical stimuli into biological responses. Piezo1 ion channels are directly gated by mechanical…”
Get full text

Author Correction: Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi by Yaganoglu, Sine, Kalyviotis, Konstantinos, Vagena-Pantoula, Christina, Jülich, Dörthe, Gaub, Benjamin M., Welling, Maaike, Lopes, Tatiana, Lachowski, Dariusz, Tang, See Swee, Del Rio Hernandez, Armando, Salem, Victoria, Müller, Daniel J., Holley, Scott A., Vermot, Julien, Shi, Jian, Helassa, Nordine, Török, Katalin, Pantazis, Periklis

Get full text

Zebrafish whole mount high-resolution double fluorescent in situ hybridization by Brend, Tim, Holley, Scott A

“…Whole mount in situ hybridization is one of the most widely used techniques in developmental biology. Here, we present a high-resolution double fluorescent in…”
Get full text

Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling by Jülich, Dörthe, Mould, A Paul, Koper, Ewa, Holley, Scott A

“…Extracellular matrixes (ECMs) coat and subdivide animal tissues, but it is unclear how ECM formation is restricted to tissue surfaces and specific cell…”
Get full text

OligoTRAFTACs: A generalizable method for transcription factor degradation by Samarasinghe, Kusal T. G, An, Elvira, Genuth, Miriam A, Chu, Ling, Holley, Scott A, Crews, Craig M

“…Dysregulated transcription factors (TFs) that rewire gene expression circuitry are frequently identified as key players in disease. Although several TFs have…”
Get full text

Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC by Holley, Scott A, Mara, Andrew, Schroeder, Joshua, Chalouni, Cécile

“…Zebrafish somitogenesis is governed by a segmentation clock that generates oscillations in expression of several Notch pathway genes, including her1, her7 and…”
Get full text

The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub by Trofka, Anna, Schwendinger-Schreck, Jamie, Brend, Tim, Pontius, William, Emonet, Thierry, Holley, Scott A

“…Using in vitro and in vivo assays, we define a network of Her/Hes dimers underlying transcriptional negative feedback within the zebrafish segmentation clock…”
Get full text

Cell cycle progression is required for zebrafish somite morphogenesis but not segmentation clock function by Zhang, Lixia, Kendrick, Christina, Jülich, Dörthe, Holley, Scott A

“…Cell division, differentiation and morphogenesis are coordinated during embryonic development, and frequently are in disarray in pathologies such as cancer…”
Get full text

Oscillators and the emergence of tissue organization during zebrafish somitogenesis by Mara, Andrew, Holley, Scott A

“…Genetic networks that include positive and negative feedback can exhibit oscillations. These oscillations are a form of emergence, which is when novel patterns…”
Get full text

Anterior-posterior differences in vertebrate segments: specification of trunk and tail somites in the zebrafish blastula by Holley, Scott A

Get full text

Integrin intra-heterodimer affinity inversely correlates with integrin activatability by Sun, Guangyu, Guillon, Emilie, Holley, Scott A.

“…Integrins are heterodimeric cell surface receptors composed of an α and β subunit that mediate cell adhesion to extracellular matrix proteins such as…”
Get full text

her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis by Holley, Scott A, Jülich, Dörthe, Rauch, Gerd-Jörg, Geisler, Robert, Nüsslein-Volhard, Christiane

“…Somite formation is thought to be regulated by an unknown oscillator mechanism that causes the cells of the presomitic mesoderm to activate and then repress…”
Get full text

Integrinα5 and Delta/Notch Signaling Have Complementary Spatiotemporal Requirements during Zebrafish Somitogenesis by Ju¨lich, Dörthe, Geisler, Robert, Holley, Scott A.

“…Somitogenesis is the process by which the segmented precursors of the skeletal muscle and vertebral column are generated during vertebrate embryogenesis. While…”
Get full text