Search Results - "Holley, Andrew J"

A sound-driven cortical phase-locking change in the Fmr1 KO mouse requires Fmr1 deletion in a subpopulation of brainstem neurons by Holley, Andrew J., Shedd, Aleya, Boggs, Anna, Lovelace, Jonathan, Erickson, Craig, Gross, Christina, Jankovic, Miranda, Razak, Khaleel, Huber, Kimberly, Gibson, Jay R.

“…Sensory impairments commonly occur in patients with autism or intellectual disability. Fragile X syndrome (FXS) is one form of intellectual disability that is…”
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Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins by Lugo, Joaquin N, Smith, Gregory D, Arbuckle, Erin P, White, Jessika, Holley, Andrew J, Floruta, Crina M, Ahmed, Nowrin, Gomez, Maribel C, Okonkwo, Obi

“…Many genes have been implicated in the underlying cause of autism but each gene accounts for only a small fraction of those diagnosed with autism. There is…”
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Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model by Dentel, Brianne, Angeles-Perez, Lidiette, Ren, Chongyu, Jakkamsetti, Vikram, Holley, Andrew J., Caballero, Daniel, Oh, Emily, Gibson, Jay, Pascual, Juan M., Huber, Kimberly M., Tu, Benjamin P., Tsai, Peter T.

“…Targeted therapies for epilepsies associated with the mTORC1 signaling negative regulator GATOR1 are lacking. NPRL2 is a subunit of the GATOR1 complex and…”
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Aniracetam does not alter cognitive and affective behavior in adult C57BL/6J mice by Elston, Thomas W, Pandian, Ashvini, Smith, Gregory D, Holley, Andrew J, Gao, Nanjing, Lugo, Joaquin N

“…There is a growing community of individuals who self-administer the nootropic aniracetam for its purported cognitive enhancing effects. Aniracetam is believed…”
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Oral aniracetam treatment in C57BL/6J mice without pre-existing cognitive dysfunction reveals no changes in learning, memory, anxiety or stereotypy [version 3; peer review: 2 approved, 1 approved with reservations] by Reynolds, Conner D, Jefferson, Taylor S, Volquardsen, Meagan, Pandian, Ashvini, Smith, Gregory D, Holley, Andrew J, Lugo, Joaquin N

“…Background: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. …”
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Oral aniracetam treatment in C57BL/6J mice without pre-existing cognitive dysfunction reveals no changes in learning, memory, anxiety or stereotypy [version 2; peer review: 2 approved, 1 approved with reservations] by Reynolds, Conner D, Jefferson, Taylor S, Volquardsen, Meagan, Pandian, Ashvini, Smith, Gregory D, Holley, Andrew J, Lugo, Joaquin N

“…Background: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. …”
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Rapamycin improves social and stereotypic behavior abnormalities induced by pre‐mitotic neuronal subset specific Pten deletion by Narvaiz, David A., Nolan, Suzanne O., Smith, Gregory D., Holley, Andrew J., Reynolds, Conner D., Blandin, Katherine J., Nguyen, Phuoc H., Tran, Doan L. K., Lugo, Joaquin N.

“…The mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to neural growth and migration. In both patients and rodent models, mutations…”
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Effects of an acute seizure on associative learning and memory by Holley, Andrew J, Lugo, Joaquin N

“…Abstract Past studies have demonstrated that inducing several seizures or continuous seizures in neonatal or adult rats results in impairments in learning and…”
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A vitamin D enriched diet attenuates sex-specific behavioral deficits, increases the lifespan, but does not rescue bone abnormalities in a mouse model of cortical dysplasia by Womble, Paige D., Hodges, Samantha L., Nolan, Suzanne O., Binder, Matthew S., Holley, Andrew J., Herrera, Rebecca, Senger, Savannah, Kwok, Eliesse, Narviaz, David A., Faust, Amanda, Hernandez-Zegada, Christian J., Kwon, Ronald Y., Lugo, Joaquin N.

“…[Display omitted] •Vitamin D enriched diet attenuated hypoactivity and rearing in the open-field test.•Vitamin D enriched diet increased percent survival in…”
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Neuronal deletion of phosphatase and tensin homolog results in cerebellar motor learning dysfunction and alterations in intracellular signaling by Nolan, Suzanne O, Jefferson, Taylor S, Reynolds, Conner D, Smith, Gregory D, Holley, Andrew J, Hodges, Samantha L, Lugo, Joaquin N

“…The purpose of this investigation was to examine cerebellar levels of several molecular signaling pathways, including PI3K/AKT/mammalian target of rapamycin…”
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Deletion of Fmr1 results in sex‐specific changes in behavior by Nolan, Suzanne O., Reynolds, Conner D., Smith, Gregory D., Holley, Andrew J., Escobar, Brianna, Chandler, Matthew A., Volquardsen, Megan, Jefferson, Taylor, Pandian, Ashvini, Smith, Tileena, Huebschman, Jessica, Lugo, Joaquin N.

“…Objective In this study, we used a systemic Fmr1 knockout in order to investigate both genotype‐ and sex‐specific differences across multiple measures of…”
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Trace fear conditioning in mice by Lugo, Joaquin N, Smith, Gregory D, Holley, Andrew J

“…In this experiment we present a technique to measure learning and memory. In the trace fear conditioning protocol presented here there are five pairings…”
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A single seizure selectively impairs hippocampal-dependent memory and is associated with alterations in PI3K/Akt/mTOR and FMRP signaling by Holley, Andrew J, Hodges, Samantha L, Nolan, Suzanne O, Binder, Matthew, Okoh, James T, Ackerman, Kaylin, Tomac, Lindsey A, Lugo, Joaquin N

“…A single brief seizure before learning leads to spatial and contextual memory impairment in rodents without chronic epilepsy. These results suggest that memory…”
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A single seizure selectively impairs hippocampal‐dependent memory and is associated with alterations in PI 3K/Akt/ mTOR and FMRP signaling by Holley, Andrew J., Hodges, Samantha L., Nolan, Suzanne O., Binder, Matthew, Okoh, James T., Ackerman, Kaylin, Tomac, Lindsey A., Lugo, Joaquin N.

“…ObjectiveA single brief seizure before learning leads to spatial and contextual memory impairment in rodents without chronic epilepsy. These results suggest…”
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Study of oral aniracetam in C57BL/6J mice without pre-existing cognitive impairments by Reynolds, Conner D., Jefferson, Taylor S., Volquardsen, Meagan, Pandian, Ashvini, Smith, Gregory D., Holley, Andrew J., Lugo, Joaquin N.

“…Background: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. …”
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Neuronal deletion of Pten results in cerebellar motor learning dysfunction and alterations in intracellular signaling by Nolan, Suzanne O., Jefferson, Taylor S., Reynolds, Conner D., Smith, Gregory D., Holley, Andrew J., Hodges, Samantha L., Lugo, Joaquin N.

“…The purpose of this investigation was to examine cerebellar levels of several molecular signaling pathways, including PI3K/AKT/mTOR signaling and markers of…”
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A Brief Seizure Prior to Learning Selectively Impairs Hippocampal Learning and Memory and Is Associated with Alterations in PI3K/Akt/mTOR and FMRP Signaling by Holley, Andrew J

“…Studies utilizing rodent models of acute seizures have indicated that a single brief seizure impairs retention of spatial and contextual memory. However, the…”
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Trace Fear Conditioning in Mice by Lugo, Joaquin N., Smith, Gregory D., Holley, Andrew J.

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The Effects of an Acute Flurothyl Seizure on Associative Learning and Memory by Holley, Andrew J

“…Past studies that utilized the flurothyl model of seizure induction have demonstrated impairment of spatial learning and memory in both neonatal and adult…”
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Teacher Training in Safety Education by Holley, J. Andrew

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