Control of low-dose heparin therapy using photometry to detect biologically active heparin

The low-dose heparin prophylaxis depends upon a low-level activation of antithrombin III to prevent thrombin generation. For the routine regiment, the application of 5000 units twice daily seems sufficient to reduce fatal lung embolism. By comparing three commercially available heparins (Thrombophob...

Full description

Saved in:

Bibliographic Details
Published in:	Chirurg Vol. 52; no. 5; p. 316
Main Authors:	Zimmermann, R E, Schwering, H, Wittrin, G, Hollenders, T
Format:	Journal Article
Language:	German
Published:	Germany 01-05-1981
Subjects:	Adult Aged Dose-Response Relationship, Drug Female Heparin - blood Heparin - therapeutic use Humans Male Middle Aged Photometry - methods Postoperative Complications - prevention & control Pulmonary Embolism - prevention & control
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The low-dose heparin prophylaxis depends upon a low-level activation of antithrombin III to prevent thrombin generation. For the routine regiment, the application of 5000 units twice daily seems sufficient to reduce fatal lung embolism. By comparing three commercially available heparins (Thrombophob, Thrombo-Vetren, Heparin-Dihydergot) the effectiveness of the so-called low-dose heparin application was controlled with a chromogenic substrate assay (Coatest, Kabivitrum). Only twice-daily Heparin-Dihydergot resulted in an average heparin level of 0.12 +/- 0.78 m/ml plasma, which was sufficient to provide an effective thrombosis prophylaxis.
ISSN:	0009-4722