Search Results - "Hollenbach, S. J."

Preclinical safety and efficacy of andexanet alfa in animal models by Lu, G., Hollenbach, S. J., Baker, D. C., Tan, S., Hutchaleelaha, A., Curnutte, J. T., Conley, P. B.

“…Essentials There is currently no approved reversal agent for factor Xa (FXa) inhibitors Andexanet alfa has been developed to reverse the anticoagulant effects…”
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Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors by LOKKER, Nathalie A, SULLIVAN, Carol M, HOLLENBACH, Stanley J, ISRAEL, Mark A, GIESE, Neill A

“…Glioblastoma multiforme, the most common form of malignant brain tumor,is resistant to all forms of therapy and causes death within 9-12 months of diagnosis…”
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Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis by Sinha, Uma, Ku, Paul, Malinowski, John, Zhu, Bing Yan, Scarborough, Robert M, Marlowe, Charles K, Wong, Paul W, Lin, Pei Hua, Hollenbach, Stanley J

“…Thrombin plays a central role in venous and arterial thrombosis. We utilized two different rabbit models of in vivo thrombosis to investigate the effect of…”
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Relative efficacy of active site-blocked factors IXa, Xa in models of rabbit venous and arterio-venous thrombosis by Wong, A G, Gunn, A C, Ku, P, Hollenbach, S J, Sinha, U

“…In order to investigate the respective roles of prothrombinase and intrinsic tenase (IXa/VIIIa) in venous thrombosis, we compared the anti-thrombotic efficacy…”
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The Challenges of Jesuit Global Education: Responses to Poverty and Displacement by Hollenbach, David

“…Jesuit higher education takes place today in an increasingly globalised world. These reflections will focus on the implications of the commitment to justice…”
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Inhibition of Purified Factor Xa Amidolytic Activity May Not Be Predictive of Inhibition of In Vivo Thrombosis: Implications for Identification of Therapeutically Active Inhibitors by Sinha, Uma, Lin, Pei Hua, Edwards, Susan T, Wong, Paul W, Zhu, Bingyan, Scarborough, Robert M, Su, Ting, Jia, Zhaozhong J, Song, Yonghong, Zhang, Penglie, Clizbe, Lane, Park, Gary, Reed, Andrea, Hollenbach, Stanley J, Malinowski, John, Arfsten, Ann E

“…OBJECTIVE—In this study we test the hypothesis that blood/plasma-based prothrombinase assays, rather than inhibition of purified factor Xa (fXa), are…”
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Regional blood flow during hypothermic arrest by Maningas, P A, DeGuzman, L R, Hollenbach, S J, Volk, K A, Bellamy, R F

“…Little is known about the efficacy of CPR in the setting of hypothermia-induced cardiac arrest. We measured organ blood flow produced by conventional…”
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Hypertonic sodium chloride solutions: effect on hemodynamics and survival after hemorrhage in swine by Traverso, L W, Bellamy, R F, Hollenbach, S J, Witcher, L D

“…We evaluated the hemodynamic response of 12% shed blood replacement with 7.5% sodium chloride after a nonlethal hemorrhage in chronically instrumented swine…”
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Early administration of methylprednisolone promotes survival in rats with intra-abdominal sepsis by Hollenbach, S J, DeGuzman, L R, Bellamy, R F

“…We determined how the following drugs affected survival of 350-gm Sprague-Dawley rats subjected to intra-abdominal sepsis according to the method of Wichterman…”
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Book Discussion Section: COMPARATIVE ETHICS, ISLAM, AND HUMAN RIGHTS: Internal Pluralism and the Possible Development of Tradition by Hollenbach, David

“…ABSTRACT Dialogue with three major Muslim authors shows that Islam can take a positive stance toward human rights while also presenting differing…”
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Naloxone does not prevent death after rapid hemorrhage in swine by Traverso, L W, Bellamy, R F, Hollenbach, S J, O'Benar, J D

“…Despite the array of hemorrhage models, animal species and experimental designs, it seems clear that naloxone with or without volume replacement has no place…”
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Religious Nationalism, a Global Ethic, and the Culture of Encounter by Hollenbach, David

“…This article sketches the global ethic proposed by Hans Küng and how Pope Francis’s writings on a culture of encounter help advance it. Religious nationalism…”
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Challenges to Religious Freedom in the USA: Some Lessons from Global Crises by Hollenbach, David

“…Religious freedom is a focus of controversy in the United States today. The leaders of some religious communities, particularly Evangelicals and Roman…”
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Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family by Pandey, Anjali, Volkots, Deborah L, Seroogy, Joseph M, Rose, Jack W, Yu, Jin-Chen, Lambing, Joseph L, Hutchaleelaha, Athiwat, Hollenbach, Stanley J, Abe, Keith, Giese, Neill A, Scarborough, Robert M

“…We have previously found that the 4-[4-(N-substituted carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazolines can function as potent and selective inhibitors of…”
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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs by PENGLIE ZHANG, LIANG BAO, LAMBING, Joseph L, HOLLENBACH, Stanley J, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, GOLDMAN, Erick A, JIA, Zhaozhong J, ARFSTEN, Ann, EDWARDS, Susan, SINHA, Uma, HUTCHALEELAHA, Athiwat, PARK, Gary

“…Anthranilamides 4 and 5 were designed and synthesized as selective and orally bioavailable factor Xa inhibitors. Structural modifications aimed at lowering…”
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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity by PENGLIE ZHANG, LIANG BAO, HOLLENBACH, Stanley J, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, JIA, Zhaozhong J, WOOLFREY, John, ARFSTEN, Ann, EDWARDS, Susan, SINHA, Uma, HUTCHALEELAHA, Athiwat, LAMBING, Joseph L

“…Compound 2 containing an aminomethylbenzoyl moiety as the S4 binding motif was synthesized in order to modulate hydrophlicity of anthranilamide-based factor Xa…”
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Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists by Mehrotra, Mukund M., Heath, Julie A., Smyth, Mark S., Pandey, Anjali, Rose, Jack W., Seroogy, Joseph M., Volkots, Deborah L., Nannizzi-Alaimo, Lisa, Park, Gary L., Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M.

“…In our efforts to develop orally active GPIIb-IIIa antagonists with improved pharmaceutical properties, we have utilized a novel 2,8-diazaspiro[4.5]decane…”
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Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor by Heath, Julie A., Mehrotra, Mukund M., Chi, Shannon, Yu, Jin-Chen, Hutchaleelaha, Athiwat, Hollenbach, Stanley J., Giese, Neill A., Scarborough, Robert M., Pandey, Anjali

“…IC 50 (βPDGFR) = 61 nM; kinase specificity: βPDGFR/Flt-3 > 100; (dog) F% = 38.8; T 1/2 = 10.8 h. 4-[4-(…”
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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors by JIA, Zhaozhong J, TING SU, WENRONG HUANG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, HUTCHALEELAHA, Athiwat, HOLLENBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, YANHONG WU, GOLDMAN, Erick A, WENHAO LI, PENGLIE ZHANG, CLIZBE, Lane A, YONGHONG SONG, BAUER, Shawn M

“…A class of N,N-dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines has been…”
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Design, synthesis and structure–Activity relationships of benzoxazinone-Based factor Xa inhibitors by Huang, Wenrong, Zhang, Penglie, Zuckett, Jingmei F, Wang, Lingyan, Woolfrey, John, Song, Yonghong, Jia, Zhaozhong J, Clizbe, Lane A, Su, Ting, Tran, Katherine, Huang, Brian, Wong, Paul, Sinha, Uma, Park, Gary, Reed, Andrea, Malinowski, John, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan

“…A series of benzoxazinone derivatives was designed and synthesized as factor Xa inhibitors. We demonstrated that the naphthyl moiety in the aniline-based…”
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