Search Results - "Hollas, Michael A. R."

Automated imaging and identification of proteoforms directly from ovarian cancer tissue by McGee, John P., Su, Pei, Durbin, Kenneth R., Hollas, Michael A. R., Bateman, Nicholas W., Maxwell, G. Larry, Conrads, Thomas P., Fellers, Ryan T., Melani, Rafael D., Camarillo, Jeannie M., Kafader, Jared O., Kelleher, Neil L.

“…The molecular identification of tissue proteoforms by top-down mass spectrometry (TDMS) is significantly limited by throughput and dynamic range. We introduce…”
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Author Correction: Automated imaging and identification of proteoforms directly from ovarian cancer tissue by McGee, John P., Su, Pei, Durbin, Kenneth R., Hollas, Michael A. R., Bateman, Nicholas W., Maxwell, G. Larry, Conrads, Thomas P., Fellers, Ryan T., Melani, Rafael D., Camarillo, Jeannie M., Kafader, Jared O., Kelleher, Neil L.

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The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms by Hollas, Michael A R, Robey, Matthew T, Fellers, Ryan T, LeDuc, Richard D, Thomas, Paul M, Kelleher, Neil L

“…Abstract The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org…”
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Automated Immunoprecipitation, Sample Preparation, and Individual Ion Mass Spectrometry Platform for Proteoforms by Des Soye, Benjamin J, McGee, John P, Hollas, Michael A R, Forte, Eleonora, Fellers, Ryan T, Melani, Rafael D, Wilkins, John T, Compton, Philip D, Kafader, Jared O, Kelleher, Neil L

“…Charge detection mass spectrometry (CDMS) is a well-established technique that provides direct mass spectral outputs regardless of analyte heterogeneity or…”
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Single Cell Analysis of Proteoforms by Su, Pei, Hollas, Michael A. R., Butun, Fatma Ayaloglu, Kanchustambham, Vijaya Lakshmi, Rubakhin, Stanislav, Ramani, Namrata, Greer, Joseph B., Early, Bryan P., Fellers, Ryan T., Caldwell, Michael A., Sweedler, Jonathan V., Kafader, Jared O., Kelleher, Neil L.

“…We introduce single cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes the benefit of direct solvent extraction and MS detection of intact…”
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Precise Readout of MEK1 Proteoforms upon MAPK Pathway Modulation by Individual Ion Mass Spectrometry by Drown, Bryon S., Gupta, Raveena, McGee, John P., Hollas, Michael A. R., Hergenrother, Paul J., Kafader, Jared O., Kelleher, Neil L.

“…The functions of proteins bearing multiple post-translational modifications (PTMs) are modulated by their modification patterns, yet precise characterization…”
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Characterization of the Antibody Response to SARS-CoV‑2 Infection in COVID-19 Transplant versus Nontransplant Recipients by Ig-MS by Des Soye, Benjamin J., Melani, Rafael D., Hollas, Michael A. R., Duan, Jiana, Patrie, Steven M., Fisher, Troy D., Mattamana, Basil Baby, Daud, Amna, Pinelli, David F., Ladner, Daniela P., Kelleher, Neil L., Forte, Eleonora

“…Solid organ transplant recipients with immunosuppressant regimens to prevent rejection are less able to mount effective immune responses to pathogenic…”
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Divergent Antibody Repertoires Found for Omicron versus Wuhan SARS-CoV‑2 Strains Using Ig-MS by Forte, Eleonora, Des Soye, Benjamin J., Melani, Rafael D., Hollas, Michael A. R., Kafader, Jared O., Sha, Beverly E., Schneider, Jeffrey R., Kelleher, Neil L.

“…SARS-CoV-2 Omicron (B.1.1.529) and its subvariants are currently the most common variants of concern worldwide, featuring numerous mutations in the spike…”
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Identification of Splice Variants and Isoforms in Transcriptomics and Proteomics by Su, Taojunfeng, Hollas, Michael A.R, Fellers, Ryan T, Kelleher, Neil L

“…Alternative splicing is pivotal to the regulation of gene expression and protein diversity in eukaryotic cells. The detection of alternative splicing events…”
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Highly multiplexed, label-free proteoform imaging of tissues by individual ion mass spectrometry by Su, Pei, McGee, John P, Durbin, Kenneth R, Hollas, Michael A R, Yang, Manxi, Neumann, Elizabeth K, Allen, Jamie L, Drown, Bryon S, Butun, Fatma Ayaloglu, Greer, Joseph B, Early, Bryan P, Fellers, Ryan T, Spraggins, Jeffrey M, Laskin, Julia, Camarillo, Jeannie M, Kafader, Jared O, Kelleher, Neil L

“…Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass…”
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Top-Down Proteomics Identifies Plasma Proteoform Signatures of Liver Cirrhosis Progression by Forte, Eleonora, Sanders, Jes M., Pla, Indira, Kanchustambham, Vijaya Lakshmi, Hollas, Michael A.R., Huang, Che-Fan, Sanchez, Aniel, Peterson, Katrina N., Melani, Rafael D., Huang, Alexander, Polineni, Praneet, Doll, Julianna M., Dietch, Zachary, Kelleher, Neil L., Ladner, Daniela P.

“…Cirrhosis, advanced liver disease, affects 2 to 5 million Americans. While most patients have compensated cirrhosis and may be fairly asymptomatic, many…”
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