Search Results - "Hollander, M Christine"

PTEN loss in the continuum of common cancers, rare syndromes and mouse models by Dennis, Phillip A, Hollander, M. Christine, Blumenthal, Gideon M

“…Key Points PTEN hamartoma tumour syndrome (PHTS) is a group of syndromes characterized by benign growths and a high risk for cancers of the breast, endometrium…”
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Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells by Bodogai, Monica, Moritoh, Kanako, Lee-Chang, Catalina, Hollander, Christine M, Sherman-Baust, Cheryl A, Wersto, Robert P, Araki, Yoshihiko, Miyoshi, Ichiro, Yang, Li, Trinchieri, Giorgio, Biragyn, Arya

“…Myeloid-derived suppressive cells (MDSC) have been reported to promote metastasis, but the loss of cancer-induced B cells/B regulatory cells (tBreg) can block…”
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miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity by Ishii, Hiroki, Vodnala, Suman K., Achyut, Bhagelu R., So, Jae Young, Hollander, M. Christine, Greten, Tim F., Lal, Ashish, Yang, Li

“…Tumor-derived soluble factors promote the production of Gr-1 + CD11b + immature myeloid cells, and TGFβ signaling is critical in their immune suppressive…”
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CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity by Zhu, Guiquan, Yan, H Hannah, Pang, Yanli, Jian, Jiang, Achyut, Bhagelu R, Liang, Xinhua, Weiss, Jonathan M, Wiltrout, Robert H, Hollander, M Christine, Yang, Li

“…Chemokines and chemokine receptors have critical roles in cancer metastasis and have emerged as one of the targeting options in cancer therapy. However, the…”
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Attenuation of Myeloid-Specific TGFβ Signaling Induces Inflammatory Cerebrovascular Disease and Stroke by Hollander, M. Christine, Latour, Lawrence L., Yang, Dan, Ishii, Hiroki, Xiao, Zhiguang, Min, Yongfen, Ray-Choudhury, Abhik, Munasinghe, Jeeva, Merchant, Anand S., Lin, P. Charles, Hallenbeck, John, Boehm, Manfred, Yang, Li

“…Cryptogenic strokes, those of unknown cause, have been estimated as high as 30% to 40% of strokes. Inflammation has been suggested as a critical etiologic…”
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Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo by GILLS, Joell J, LOPICCOLO, Jaclyn, HOLLANDER, M. Christine, KAWABATA, Shigeru, TSOKOS, Maria, FIGG, William D, STEEG, Patricia S, DENNIS, Phillip A, TSURUTANI, Junji, SHOEMAKER, Robert H, BEST, Carolyn J. M, ABU-ASAB, Mones S, BOROJERDI, Jennifer, WARFEL, Noel A, GARDNER, Erin R, DANISH, Matthew

“…Purpose: The development of new cancer drugs is slow and costly. HIV protease inhibitors are Food and Drug Administration approved for HIV patients. Because…”
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Platelet factor 4 is produced by subsets of myeloid cells in premetastatic lung and inhibits tumor metastasis by Jian, Jiang, Pang, Yanli, Yan, H Hannah, Min, Yongfen, Achyut, Bhagelu R, Hollander, M Christine, Lin, P Charles, Liang, Xinhua, Yang, Li

“…Bone marrow-derived myeloid cells can form a premetastatic niche and provide a tumor-promoting microenvironment. However, subsets of myeloid cells have also…”
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Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance by Zhang, Chunyu, Elkahloun, Abdel G, Robertson, Matthew, Gills, Joell J, Tsurutani, Junji, Shih, Joanna H, Fukuoka, Junya, Hollander, M Christine, Harris, Curtis C, Travis, William D, Jen, Jin, Dennis, Phillip A

“…The dismal lethality of lung cancer is due to late stage at diagnosis and inherent therapeutic resistance. The incorporation of targeted therapies has modestly…”
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Rapamycin Prevents the Development and Progression of Mutant Epidermal Growth Factor Receptor Lung Tumors with the Acquired Resistance Mutation T790M by Kawabata, Shigeru, Mercado-Matos, José R., Hollander, M. Christine, Donahue, Danielle, Wilson, Willie, Regales, Lucia, Butaney, Mohit, Pao, William, Wong, Kwok-Kin, Jänne, Pasi A., Dennis, Phillip A.

“…Lung cancer in never-smokers is an important disease often characterized by mutations in epidermal growth factor receptor (EGFR), yet risk reduction measures…”
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Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas by Wang, Yun, DiGiovanna, John J, Stern, Jere B, Hornyak, Thomas J, Raffeld, Mark, Khan, Sikandar G, Oh, Kyu-Seon, Hollander, M. Christine, Dennis, Philip A, Kraemer, Kenneth H

“…To look for a direct role of ultraviolet radiation (UV) exposure in cutaneous melanoma induction, we studied xeroderma pigmentosum (XP) patients who have…”
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Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone by Kawabata, Shigeru, Hollander, M Christine, Munasinghe, Jeeva P, Brinster, Lauren R, Mercado-Matos, José R, Li, Jie, Regales, Lucia, Pao, William, Jänne, Pasi A, Wong, Kwok-Kin, Butman, John A, Lonser, Russell R, Hansen, Marlan R, Gurgel, Richard K, Vortmeyer, Alexander O, Dennis, Phillip A

“…Adenomatous tumors in the middle ear and temporal bone are rare but highly morbid because they are difficult to detect prior to the development of…”
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A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis by Granville, Courtney A, Memmott, Regan M, Balogh, Andria, Mariotti, Jacopo, Kawabata, Shigeru, Han, Wei, Lopiccolo, Jaclyn, Foley, Jason, Liewehr, David J, Steinberg, Seth M, Fowler, Daniel H, Hollander, M Christine, Dennis, Phillip A

“…K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary…”
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Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen–Induced Murine Lung Tumors by GRANVILLE, Courtney A, WARFEL, Noel, TSURUTANI, Junji, HOLLANDER, M. Christine, ROBERTSON, Matthew, FOX, Stephen D, VEENSTRA, Timothy D, ISSAQ, Haleem J, LINNOILA, R. Llona, DENNIS, Phillip A

“…Purpose: Human and murine preneoplastic lung lesions induced by tobacco exposure are characterized by increased activation of the Akt/mammalian target of…”
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Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a by Hollander, M Christine, Fornace, Jr, Albert J

“…Genomic instability has been a recognized feature of many human tumors for decades. Until recently, however, there was little insight into potential mechanisms…”
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Deletion of XPC Leads to Lung Tumors in Mice and Is Associated with Early Events in Human Lung Carcinogenesis by Hollander, M. Christine, Philburn, Robyn T., Patterson, Andrew D., Velasco-Miguel, Susana, Friedberg, Errol C., Linnoila, R. Ilona, Fornace, Albert J., Setlow, Richard B.

“…Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been…”
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Loss of Oncogenic H-ras-Induced Cell Cycle Arrest and p38 Mitogen-Activated Protein Kinase Activation by Disruption of Gadd45a by Bulavin, Dmitry V., Kovalsky, Oleg, Hollander, M. Christine, Fornace, Albert J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gadd34 functional domains involved in growth suppression and apoptosis by HOLLANDER, M. Christine, POOLA-KELLA, Silpa, FORNACE, Albert J

“…Gadd34 (also known as MyD116) was originally described as a growth arrest and DNA damage-inducible gene. Increased expression of Gadd34 was subsequently found…”
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Gadd34 Requirement for Normal Hemoglobin Synthesis by Patterson, Andrew D., Hollander, M. Christine, Miller, Georgina F., Fornace, Albert J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inhibition of Lung Tumorigenesis by Metformin Is Associated with Decreased Plasma IGF-I and Diminished Receptor Tyrosine Kinase Signaling by QUINN, Brendan J, DALLOS, Matthew, KITAGAWA, Hiroshi, KUNNUMAKKARA, Ajaikumar B, MEMMOTT, Regan M, HOLLANDER, M. Christine, GILLS, Joell J, DENNIS, Phillip A

“…Metformin is the most commonly prescribed drug for type II diabetes and is associated with decreased cancer risk. Previously, we showed that metformin…”
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Loss of myeloid‐specific lamin A/C drives lung metastasis through Gfi‐1 and C/EBPε‐mediated granulocytic differentiation by Ishii, Hiroki, Park, Woo‐Yong, So, Jaeyoung, Kuhn, Skyler, Koparde, Vishal N., Pang, Yanli, Greten, Tim F., Hollander, M. Christine, Yang, Li

“…The immune‐suppressive tumor microenvironment promotes metastatic spread and outgrowth. One of the major contributors is tumor‐associated myeloid cells…”
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