Search Results - "Holland, Trevin"
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Targeted Access to the Genomes of Low-Abundance Organisms in Complex Microbial Communities
Published in Applied and Environmental Microbiology (01-05-2007)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies
Published in Proceedings of the National Academy of Sciences - PNAS (20-12-2011)“…A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling…”
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A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities
Published in Acta neuropathologica communications (31-05-2018)“…Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B…”
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Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology
Published in Acta neuropathologica (01-05-2019)“…Deposition of α-synuclein into Lewy bodies and Lewy neurites is the hallmark of Parkinson’s disease (PD). It is hypothesized that α-synuclein pathology spreads…”
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Immunological memory to hyperphosphorylated tau in asymptomatic individuals
Published in Acta neuropathologica (01-05-2017)“…Several reports have described the presence of antibodies against Alzheimer’s disease-associated hyperphosphorylated forms of tau in serum of healthy…”
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A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities
Published in Acta neuropathologica communications (31-05-2018)“…Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG memory B…”
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High-throughput cultivation of microorganisms using microcapsules
Published in Methods in enzymology (2005)“…This chapter describes a universal and novel method that provides access to the immense reservoir of untapped microbial diversity by cultivation. This…”
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Targeted Access to the Genomes of Low Abundance Organisms in Complex Microbial Communities
Published in Applied and environmental microbiology (01-01-2007)“…Current metagenomic approaches to the study of complex microbial consortia provide a glimpse into the community metabolism, and occasionally allow genomic…”
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Structural characterization of the cell wall binding domains of Clostridium difficile toxins A and B; evidence that Ca2+ plays a role in toxin A cell surface association
Published in Journal of molecular biology (11-03-2005)“…Clostridium difficile (C.difficile) is a nosocomially acquired intestinal bacillus which can cause chronic diarrhea and life-threatening colitis. The…”
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10
Structural Characterization of the Cell Wall Binding Domains of Clostridium difficile Toxins A and B; Evidence that Ca 2+ Plays a Role in Toxin A Cell Surface Association
Published in Journal of molecular biology (2005)“…Clostridium difficile ( C. difficile ) is a nosocomially acquired intestinal bacillus which can cause chronic diarrhea and life-threatening colitis. The…”
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