Search Results - "Holland, S J"

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands by Holland, Sacha J, Gale, Nicholas W, Mbamalu, Geraldine, Yancopoulos, George D, Henkemeyer, Mark, Pawson, Tony

“…Receptor tyrosine kinases of the EPH class have been implicated in the control of axon guidance and fasciculation, in regulating cell migration, and in…”
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Downregulation of the Ras–Mitogen-Activated Protein Kinase Pathway by the EphB2 Receptor Tyrosine Kinase Is Required for Ephrin-Induced Neurite Retraction by Elowe, Sabine, Holland, Sacha J., Kulkarni, Sarang, Pawson, Tony

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mutant U5A cells are complemented by an interferon‐alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster by Lutfalla, G., Holland, S. J., Cinato, E., Monneron, D., Reboul, J., Rogers, N. C., Smith, J. M., Stark, G. R., Gardiner, K., Mogensen, K. E.

“…The cellular receptor for the alpha/beta interferons contains at least two components that interact with interferon. The ifnar1 component is well characterized…”
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Factors affecting gestation length in the Thoroughbred mare by Davies Morel, M.C.G, Newcombe, J.R, Holland, S.J

“…In order to assist in the accurate prediction of the timing of parturition in the mare true gestation length, along with the potential effect of a number of…”
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Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator by Lain, Sonia, Hollick, Jonathan J., Campbell, Johanna, Staples, Oliver D., Higgins, Maureen, Aoubala, Mustapha, McCarthy, Anna, Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Mathers, Joanne, Holland, Stephen J., Stark, Michael J.R., Pass, Georgia, Woods, Julie, Lane, David P., Westwood, Nicholas J.

“…We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we…”
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Ultrasonic degradation for molecular weight reduction of pharmaceutical cellulose ethers by Goodwin, D.J., Picout, D.R., Ross-Murphy, S.B., Holland, S.J., Martini, L.G., Lawrence, M.J.

“…Several pharmaceutical grade cellulose ethers, hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC) and…”
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Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors by Binns, Kathleen L., Taylor, Paul P., Sicheri, Frank, Pawson, Tony, Holland, Sacha J.

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Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis by Gale, Nicholas W, Holland, Sacha J, Valenzuela, David M, Flenniken, Ann, Pan, Li, Ryan, Terrence E, Henkemeyer, Mark, Strebhardt, Klaus, Hirai, Hisamaru, Wilkinson, David G, Pawson, Tony, Davis, Samuel, Yancopoulos, George D

“…We report that the many Eph-related receptor tyrosine kinases, and their numerous membrane-bound ligands, can each be grouped into only two major specificity…”
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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells by Holland, Sacha J., Gale, Nicholas W., Gish, Gerald D., Roth, Richard A., Songyang, Zhou, Cantley, Lewis C., Henkemeyer, Mark, Yancopoulos, George D., Pawson, Tony

“…Eph‐related receptor tyrosine kinases have been implicated in the control of axonal navigation and fasciculation. To investigate the biochemical mechanisms…”
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Identification and specificity of pilus adsorption proteins of filamentous bacteriophages infecting Pseudomonas aeruginosa by Holland, Samantha J., Sanz, Carolina, Perham, Richard N.

“…Filamentous bacteriophages Pf1 and Pf3 infect Pseudomonas aeruginosa strains K and O, respectively. We show here that the capsids of these bacteriophages each…”
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Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β by Holland, Sacha J, Peles, Elior, Pawson, Tony, Schlessinger, Joseph

“…The growth and guidance of axons involves the recognition of complex environmental cues by receptor proteins on the surface of the growth cone and their…”
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Multiple Ephrins Control Cell Organization in C. elegans Using Kinase-Dependent and -Independent Functions of the VAB-1 Eph Receptor by Wang, Xiangmin, Roy, Peter J., Holland, Sacha J., Zhang, Lijia W., Culotti, Joseph G., Pawson, Tony

“…Eph receptor (EphR) tyrosine kinases and their ephrin ligands mediate direct cell-to-cell signaling. The C. elegans genome encodes four potential GPI-modified…”
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Soluble CD46 (membrane cofactor protein, MCP) in human reproductive tract fluids by McLaughlin, P.J., Holland, S.J., Taylor, C.T., Olah, K.S., Lewis-Jones, D.I., Hara, T., Seya, T., Johnson, P.M.

“…CD46 (membrane cofactor protein, MCP) is a cell surface complement regulatory protein which may have an additional role in human sperm-egg interaction. A…”
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Polymers for biodegradable medical devices. II. Hydroxybutyrate-hydroxyvalerate copolymers: hydrolytic degradation studies by Holland, S J, Jolly, A M, Yasin, M, Tighe, B J

“…The hydrolytic degradation of poly(hydroxybutyrate) together with a series of hydroxybutyrate-hydroxyvalerate copolymers has been studied. The effects of…”
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Stability of dexamethasone sodium phosphate, diphenhydramine hydrochloride, lorazepam, and metoclopramide hydrochloride in portable infusion-pump reservoirs by Stiles, M L, Allen, Jr, L V, Prince, S J, Holland, J S

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Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling by Holland, S J, Liao, X C, Mendenhall, M K, Zhou, X, Pardo, J, Chu, P, Spencer, C, Fu, A, Sheng, N, Yu, P, Pali, E, Nagin, A, Shen, M, Yu, S, Chan, E, Wu, X, Li, C, Woisetschlager, M, Aversa, G, Kolbinger, F, Bennett, M K, Molineaux, S, Luo, Y, Payan, D G, Mancebo, H S, Wu, J

“…In an effort to identify novel therapeutic targets for autoimmunity and transplant rejection, we developed and performed a large-scale retroviral-based…”
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Fine Specificity of the Myelin-Reactive T Cell Repertoire: Implications for TCR Antagonism in Autoimmunity by Anderton, Stephen M, Manickasingham, Shivanthi P, Burkhart, Christoph, Luckcuck, Tracy A, Holland, Sam J, Lamont, Alan G, Wraith, David C

“…The use of altered peptide ligands (APL) to modulate T cell responses has been suggested as a means of treating T cell-mediated autoimmune disorders. We have…”
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Polymers for biodegradable medical devices. VII. Hydroxybutyrate-hydroxyvalerate copolymers: degradation of copolymers and their blends with polysaccharides under in vitro physiological conditions by Holland, S J, Yasin, M, Tighe, B J

“…The hydrolytic degradation of hydroxybutyrate-hydroxyvalerate copolymers was monitored in vitro at 37 degrees C and pH 7.4. Direct use of bulk properties such…”
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Polymers for biodegradable medical devices. V. Hydroxybutyrate-hydroxyvalerate copolymers: effects of polymer processing on hydrolytic degradation by Yasin, M, Holland, S J, Tighe, B J

“…The effects of melt processing on those properties of polyhydroxybutyrate-hydroxyvalerate copolymers that control hydrolytic stability were studied. Initial…”
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Polymers for biodegradable medical devices. VI. Hydroxybutyrate-hydroxyvalerate copolymers: accelerated degradation of blends with polysaccharides by Yasin, M, Holland, S J, Jolly, A M, Tighe, B J

“…The hydrolytic degradation of poly(hydroxybutyrate)-poly(hydroxyvalerate) (PHB-PHV) copolymers in the form of blends with the polysaccharides amylose, dextran,…”
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