Search Results - "Holland, Negin"

Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales by Williams, Rebecca S., Adams, Natalie E., Hughes, Laura E., Rouse, Matthew A., Murley, Alexander G., Naessens, Michelle, Street, Duncan, Holland, Negin, Rowe, James B.

“…Self-report scales are widely used in cognitive neuroscience and psychology. However, they rest on the central assumption that respondents engage meaningfully…”
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Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration by Whiteside, David J., Holland, Negin, Tsvetanov, Kamen A., Mak, Elijah, Malpetti, Maura, Savulich, George, Jones, P. Simon, Naessens, Michelle, Rouse, Matthew A., Fryer, Tim D., Hong, Young T., Aigbirhio, Franklin I., Mulroy, Eoin, Bhatia, Kailash P., Rittman, Timothy, O’Brien, John T., Rowe, James B.

“…There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the…”
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Synaptic density in carriers of C9orf72 mutations: a [11C]UCB‐J PET study by Malpetti, Maura, Holland, Negin, Jones, P. Simon, Ye, Rong, Cope, Thomas E., Fryer, Tim D., Hong, Young T., Savulich, George, Rittman, Timothy, Passamonti, Luca, Mak, Elijah, Aigbirhio, Franklin I., O’Brien, John T., Rowe, James B.

“…Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia…”
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Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features by Low, Audrey, Mak, Elijah, Malpetti, Maura, Chouliaras, Leonidas, Nicastro, Nicolas, Su, Li, Holland, Negin, Rittman, Timothy, Rodríguez, Patricia Vázquez, Passamonti, Luca, Bevan-Jones, W Richard, Jones, PP Simon, Rowe, James B., O'Brien, John T.

“…Although widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD…”
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11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies by Nicastro, Nicolas, Holland, Negin, Savulich, George, Carter, Stephen F., Mak, Elijah, Hong, Young T., Milicevic Sephton, Selena, Fryer, Tim D., Aigbirhio, Franklin I., Rowe, James B., O’Brien, John T.

“…Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is associated…”
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The role of noradrenaline in cognition and cognitive disorders by Holland, Negin, Robbins, Trevor W, Rowe, James B

“…Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha…”
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A synergistic core for human brain evolution and cognition by Luppi, Andrea I., Mediano, Pedro A. M., Rosas, Fernando E., Holland, Negin, Fryer, Tim D., O’Brien, John T., Rowe, James B., Menon, David K., Bor, Daniel, Stamatakis, Emmanuel A.

“…How does the organization of neural information processing enable humans’ sophisticated cognition? Here we decompose functional interactions between brain…”
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Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease by O'Callaghan, Claire, Hezemans, Frank H, Ye, Rong, Rua, Catarina, Jones, P Simon, Murley, Alexander G, Holland, Negin, Regenthal, Ralf, Tsvetanov, Kamen A, Wolpe, Noham, Barker, Roger A, Williams-Gray, Caroline H, Robbins, Trevor W, Passamonti, Luca, Rowe, James B

“…Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore,…”
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Synaptic Loss in Primary Tauopathies Revealed by [11C]UCB‐J Positron Emission Tomography by Holland, Negin, Jones, P. Simon, Savulich, George, Wiggins, Julie K., Hong, Young T., Fryer, Tim D., Manavaki, Roido, Sephton, Selena Milicevic, Boros, Istvan, Malpetti, Maura, Hezemans, Frank H., Aigbirhio, Franklin I., Coles, Jonathan P., O’Brien, John, Rowe, James B.

“…Background Synaptic loss is a prominent and early feature of many neurodegenerative diseases. Objectives We tested the hypothesis that synaptic density is…”
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The impact of misdiagnosing Bell’s palsy as acute stroke by Induruwa, Isuru, Holland, Negin, Gregory, Rosalind, Khadjooi, Kayvan

“…Idiopathic Bell’s palsy can lead to a serious and, sometimes permanently, disfiguring and emotionally challenging facial palsy. Early diagnosis and treatment…”
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Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders by Ye, Rong, O'Callaghan, Claire, Rua, Catarina, Hezemans, Frank H., Holland, Negin, Malpetti, Maura, Jones, P. Simon, Barker, Roger A., Williams‐Gray, Caroline H., Robbins, Trevor W., Passamonti, Luca, Rowe, James

“…Background Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric symptoms in both Parkinson's disease (PD) and progressive supranuclear…”
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GABAergic cortical network physiology in frontotemporal lobar degeneration by Adams, Natalie E, Hughes, Laura E, Rouse, Matthew A, Phillips, Holly N, Shaw, Alexander D, Murley, Alexander G, Cope, Thomas E, Bevan-Jones, W Richard, Passamonti, Luca, Street, Duncan, Holland, Negin, Nesbitt, David, Friston, Karl, Rowe, James B

“…The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous, including the behavioural variant frontotemporal dementia (bvFTD) and…”
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Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome by Jabbari, Edwin, Holland, Negin, Chelban, Viorica, Jones, P Simon, Lamb, Ruth, Rawlinson, Charlotte, Guo, Tong, Costantini, Alyssa A, Tan, Manuela M X, Heslegrave, Amanda J, Roncaroli, Federico, Klein, Johannes C, Ansorge, Olaf, Allinson, Kieren S J, Jaunmuktane, Zane, Holton, Janice L, Revesz, Tamas, Warner, Thomas T, Lees, Andrew J, Zetterberg, Henrik, Russell, Lucy L, Bocchetta, Martina, Rohrer, Jonathan D, Williams, Nigel M, Grosset, Donald G, Burn, David J, Pavese, Nicola, Gerhard, Alexander, Kobylecki, Christopher, Leigh, P Nigel, Church, Alistair, Hu, Michele T M, Woodside, John, Houlden, Henry, Rowe, James B, Morris, Huw R

“…Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be…”
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Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study by Holland, Negin, Malpetti, Maura, Rittman, Timothy, Mak, Elijah E, Passamonti, Luca, Kaalund, Sanne S, Hezemans, Frank H, Jones, P Simon, Savulich, George, Hong, Young T, Fryer, Tim D, Aigbirhio, Franklin I, O'Brien, John T, Rowe, James B

“…The relationship between in vivo synaptic density and molecular pathology in primary tauopathies is key to understanding the impact of tauopathy on functional…”
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Multi‐modal MR and synaptic PET changes in dementia with Lewy bodies by Mak, Elijah, Carter, Stephen F, Savulich, George, Holland, Negin, Swann, Peter, McKiernan, Elizabeth, Chouliaras, Leonidas, Malpetti, Maura, Su, Li, Jones, P Simon, Rowe, James B., O'Brien, John T

“…Background Novel, validated imaging biomarkers for assessing disease severity and progression in dementia with Lewy Bodies (DLB) are needed as standard…”
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Misdiagnosing Bell's palsy as acute stroke/Response by Elkeles, Robert, Induruwa, Isuru, Holland, Negin, Gregory, Rosalind, Khadjooi, Kayvan

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Response by Induruwa, Isuru, Holland, Negin, Gregory, Rosalind, Khadjooi, Kayvan

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Response by Induruwa, Isuru, Holland, Negin, Gregory, Rosalind, Khadjooi, Kayvan

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Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy by Ye, Rong, Hezemans, Frank H, O'Callaghan, Claire, Tsvetanov, Kamen A, Rua, Catarina, Jones, P Simon, Holland, Negin, Malpetti, Maura, Murley, Alexander G, Barker, Roger A, Williams-Gray, Caroline H, Robbins, Trevor W, Passamonti, Luca, Rowe, James B

“…Parkinson's disease (PD) and progressive supranuclear palsy (PSP) both impair response inhibition, exacerbating impulsivity. Inhibitory control deficits vary…”
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Differential Synaptic Loss in β‐Amyloid Positive Versus β‐Amyloid Negative Corticobasal Syndrome by Holland, Negin, Savulich, George, Jones, P. Simon, Whiteside, David J., Street, Duncan, Swann, Peter, Naessens, Michelle, Malpetti, Maura, Hong, Young T., Fryer, Tim D., Rittman, Timothy, Mulroy, Eoin, Aigbirhio, Franklin I., Bhatia, Kailash P., O'Brien, John T., Rowe, James B.

“…Background/Objective The corticobasal syndrome (CBS) is a complex asymmetric movement disorder, with cognitive impairment. Although commonly associated with…”
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