Search Results - "Holland, David O"

Characterization and clustering of kinase isoform expression in metastatic melanoma by Holland, David O, Gotea, Valer, Fedkenheuer, Kevin, Jaiswal, Sushil K, Baugher, Catherine, Tan, Hua, Fedkenheuer, Michael, Elnitski, Laura

“…Mutations to the human kinome are known to play causal roles in cancer. The kinome regulates numerous cell processes including growth, proliferation,…”
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Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis by Duan, Daisy, Hanson, Meretta, Holland, David O., Johnson, Margaret E.

“…Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at copy numbers within a cell and across cell types varying from hundreds…”
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Stoichiometric balance of protein copy numbers is measurable and functionally significant in a protein-protein interaction network for yeast endocytosis by Holland, David O, Johnson, Margaret E

“…Stoichiometric balance, or dosage balance, implies that proteins that are subunits of obligate complexes (e.g. the ribosome) should have copy numbers expressed…”
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Protein-protein binding selectivity and network topology constrain global and local properties of interface binding networks by Holland, David O., Shapiro, Benjamin H., Xue, Pei, Johnson, Margaret E.

“…Protein-protein interactions networks (PPINs) are known to share a highly conserved structure across all organisms. What is poorly understood, however, is the…”
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Graphical approach to model reduction for nonlinear biochemical networks by Holland, David O, Krainak, Nicholas C, Saucerman, Jeffrey J

“…Model reduction is a central challenge to the development and analysis of multiscale physiology models. Advances in model reduction are needed not only for…”
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Methotrexate-based PROTACs as DHFR-specific chemical probes by Rana, Sandeep, Dranchak, Patricia, Dahlin, Jayme L, Lamy, Laurence, Li, Wenqing, Oliphant, Erin, Shrimp, Jonathan H, Rajacharya, Girish H, Tharakan, Ravi, Holland, David O, Whitten, Apryl S, Wilson, Kelli M, Singh, Pankaj K, Durum, Scott K, Tao, Dingyin, Rai, Ganesha, Inglese, James

“…Methotrexate (MTX) is a tight-binding dihydrofolate reductase (DHFR) inhibitor, used as both an antineoplastic and immunosuppressant therapeutic. MTX, like…”
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Network Reconstruction and Systems Analysis of Cardiac Myocyte Hypertrophy Signaling by Ryall, Karen A., Holland, David O., Delaney, Kyle A., Kraeutler, Matthew J., Parker, Audrey J., Saucerman, Jeffrey J.

“…Cardiac hypertrophy is managed by a dense web of signaling pathways with many pathways influencing myocyte growth. A quantitative understanding of the…”
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Evaluating Stacked Methylation Markers for Blood-Based Multicancer Detection by Funderburk, Karen, Bang-Christensen, Sara R, Miller, Brendan F, Tan, Hua, Margolin, Gennady, Petrykowska, Hanna M, Baugher, Catherine, Farney, S Katie, Grimm, Sara A, Jameel, Nader, Holland, David O, Altman, Naomi S, Elnitski, Laura

“…The ability to detect several types of cancer using a non-invasive, blood-based test holds the potential to revolutionize oncology screening. We mined tumor…”
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Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts by Arakawa, Yasuhiro, Jo, Ukhyun, Kumar, Suresh, Sun, Nai-Yun, Elloumi, Fathi, Thomas, Anish, Roper, Nitin, Varghese, Diana Grace, Takebe, Naoko, Zhang, Xiaohu, Ceribelli, Michele, Holland, David O, Beck, Erin, Itkin, Zina, McKnight, Crystal, Wilson, Kelli M, Travers, Jameson, Klumpp-Thomas, Carleen, Thomas, Craig J, Hoang, Chuong D, Hernandez, Jonathan M, Del Rivero, Jaydira, Pommier, Yves

“…Current treatment options for metastatic adrenocortical carcinoma (ACC) have limited efficacy, despite the common use of mitotane and cytotoxic agents. This…”
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Optimizing Protein Specificity in the Crowded Cell through Concentration Balance and Network motif Selection by Holland, David O., Johnson, Margaret E.

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Optimizing Protein Expression Levels as a Function of Network Topology Minimizes Nonfunctional Complex Formation by Holland, David O., Johnson, Margaret E.

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