Search Results - "Holladay, S."

Lead alters intracellular protein signaling and suppresses pro-inflammatory activation in TLR4 and IFNR-stimulated murine RAW 264.7 cells, in vitro by Williams, R.J., Karpuzoglu, E., Connell, H., Hurley, D.J., Holladay, S.D, Gogal, R.M.

“…Lead (Pb) is a persistent environmental pollutant that has a structure and charge similar to many ions, such as calcium, that are essential for normal cellular…”
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A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice by Mustafa, A, Holladay, S.D, Witonsky, S, Sponenberg, D.P, Karpuzoglu, E, Gogal, R.M

“…Highlights ► Prenatal TCDD altered the postnatal immune system, and differently so based on sex. ► Immune dysregulation affected both T and B cells,…”
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Effects of activating NK cell receptor expression and NK cell reconstitution on the outcomes of unrelated donor hematopoietic cell transplantation for hematologic malignancies by Triplett, B M, Horwitz, E M, Iyengar, R, Turner, V, Holladay, M S, Gan, K, Behm, F G, Leung, W

“…Inhibitory NK cell receptors are recognized as important determinants of NK cell activity in hematopoietic cell transplantation (HCT). The role of activating…”
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Placental Oxidative Stress Alters Expression of Murine Osteogenic Genes and Impairs Fetal Skeletal Formation by Prater, M.R, Laudermilch, C.L, Liang, C, Holladay, S.D

“…Abstract Fetal and placental developments rely on an intricate balance of nutrients, growth factors, and signaling pathways at precise times in gestation…”
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Observations of sea ice thickness, surface roughness and ice motion in Amundsen Gulf by Peterson, I. K., Prinsenberg, S. J., Holladay, J. S.

“…Ice thickness and surface roughness measurements of first‐year (FY) sea ice were collected with a fix‐mounted helicopter‐borne electromagnetic (HEM) ‐laser…”
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Inhibitory KIR-HLA receptor-ligand mismatch in autologous haematopoietic stem cell transplantation for solid tumour and lymphoma by LEUNG, W, HANDGRETINGER, R, LYENGAR, R, TURNER, V, HOLLADAY, M. S, HALE, G. A

“…Genes that encode killer Ig-like receptors (KIRs) and their HLA class I ligands segregate independently; thus, some individuals may express an inhibitory KIR…”
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An enhanced postnatal autoimmune profile in 24 week-old C57BL/6 mice developmentally exposed to TCDD by Mustafa, A., Holladay, S.D., Goff, M., Witonsky, S.G., Kerr, R., Reilly, C.M., Sponenberg, D.P., Gogal, R.M.

“…Developmental exposure of mice to the environmental contaminant and AhR agonist, 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), causes persistent postnatal…”
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Exposure of juvenile Leghorn chickens to lead acetate enhances antibiotic resistance in enteric bacterial flora by Nisanian, M, Holladay, S D, Karpuzoglu, E, Kerr, R P, Williams, S M, Stabler, L, McArthur, J Vaun, Tuckfield, R Cary, Gogal, Jr, R M

“…Heavy metals have been implicated for their ability to increase antibiotic resistance in bacteria collected from polluted waters, independent of antibiotic…”
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Persistent Increase of Blood Lead Level and Suppression of δ-ALAD Activity in Northern Bobwhite Quail Orally Dosed With Even a Single 2-mm Spent Lead Shot by Holladay, S. D., Kerr, R., Holladay, J. P., Meldrum, B., Williams, S. M., Gogal, R. M.

“…Birds that display grit ingestion behavior are potentially at risk of lead (Pb) poisoning from mistaken ingestion of spent Pb shot pellets. The majority of…”
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Comparison of Killer Ig-Like Receptor Genotyping and Phenotyping for Selection of Allogeneic Blood Stem Cell Donors by Leung, Wing, Iyengar, Rekha, Triplett, Brandon, Turner, Victoria, Behm, Frederick G, Holladay, Marti S, Houston, James, Handgretinger, Rupert

“…The repertoire of killer Ig-like receptors (KIRs) can be determined at the level of DNA, RNA, or surface protein expression for selection of blood stem cell…”
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Excretion of three heavy metals in the shed skin of exposed corn snakes ( Elaphe guttata) by Jones, D.E., Holladay, S.D.

“…Three heavy metals of regional environmental concern—lead, cadmium, and mercury—are frequently evaluated as part of wildlife bioaccumulation and health…”
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Lead at 2.5 and 5.0μM induced aberrant MH-II surface expression through increased MII exocytosis and increased autophagosome formation in Raw 267.4 cells by Kerr, R.P., Krunkosky, T.M., Hurley, D.J., Cummings, B.S., Holladay, S.D., Gogal, R.M.

“…► Lead (Pb), at >25μM, increases MHC-II surface expression resulting in immune dysregulation. ► Data on exposure to environmentally relevant Pb levels in…”
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Development of the Murine and Human Immune System: Differential Effects of Immunotoxicants Depend on Time of Exposure by Holladay, Steven D., Smialowicz, Ralph J.

“…Fetal and early postnatal life represent critical periods in vertebrate immune system development. Disruption of such development by perinatal immunotoxic…”
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Perinatal TCDD exposure and the adult onset of autoimmune disease by Gogal, Jr, R M, Holladay, S D

“…Modulation of the developing immune system can occur following perinatal exposure to a number of immunotoxic compounds, including polyhalogenated hydrocarbons…”
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Role of Proinflammatory Cytokines in Acetaminophen Hepatotoxicity by Blazka, M.E., Wilmer, J.L., Holladay, S.D., Wilson, R.E., Luster, M.I.

“…Acetaminophen (APAP) intoxication has been shown to activate Kupffer cells. Kupffer cell activation is also associated with the release of proinflammatory…”
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Detection of polycyclic aromatic hydrocarbons in the shed skins of corn snakes ( Elaphe guttata) by Jones, D.E., Magnin-Bissel, G., Holladay, S.D.

“…Previous work has shown that organochlorine compounds, including chlordane, lindane and polychlorinated biphenyls, and heavy metals, including lead, mercury…”
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Early identification of Epstein-Barr virus-associated post-transplantation lymphoproliferative disease by Rooney, C M, Loftin, S K, Holladay, M S, Brenner, M K, Krance, R A, Heslop, H E

“…Epstein-Barr virus-associated lymphoproliferative disease (EBV-LPD) is a common, usually fatal, complication developing after transplantation of bone marrow…”
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Phenotype and function of human natural killer cells purified by using a clinical-scale immunomagnetic method by WING LEUNG, IYENGAR, Rekha, LEIMIG, Thasia, HOLLADAY, Marti S, HOUSTON, James, HANDGRETINGER, Rupert

“…Infection, disease relapse, graft failure, and graft-versus-host disease (GVHD) are significant adverse events associated with allogeneic bone marrow…”
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Single-dose topical exposure to the pyrethroid insecticide, permethrin in C57BL/6N mice: effects on thymus and spleen by Prater, M.R., Gogal Jr, R.M., Blaylock, B.L., Longstreth, J., Holladay, S.D.

“…Immunomodulatory effects of single topical exposure to permethrin were evaluated in 5-week-old female C57BL/6N mice. Mice exposed to 5–25 μl permethrin…”
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Role of Maternal Dietary Antioxidant Supplementation in Murine Placental and Fetal Limb Development by Prater, M.R., Zimmerman, K.L., Pinn, L.C., Keay, J.M., Laudermilch, C.L., Holladay, S.D.

“…Methylnitrosourea (MNU) is a multisystem teratogen that damages proliferating cells through macromolecule alkylation and generation of reactive oxygen species…”
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