Search Results - "Holla, Ø. L."

Characterization of novel mutations in the catalytic domain of the PCSK9 gene by Cameron, J., Holla, Ø. L., Laerdahl, J. K., Kulseth, M. A., Ranheim, T., Rognes, T., Berge, K. E., Leren, T. P.

“… Objectives.  To expand our understanding of the structure and function of proprotein convertase subtilisin/kexin type 9 (PCSK9) by studying how naturally…”
Get full text

Low-density lipoprotein receptor activity in Epstein-Barr virus-transformed lymphocytes from heterozygotes for the D374Y mutation in the PCSK9 gene by Holla, Ø. L., Cameron, J., Berge, K. E., Kulseth, M. A., Ranheim, T., Leren, T. P.

“…Objective. Missense mutations in the proprotein convertase subtilisin kexin type 9 (PCSK9) gene have been found to cause autosomal dominant…”
Get full text

Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification by TVETEN, Kristian, HOLLA, Øystein L, CAMERON, Jamie, BISMO STRØM, Thea, ERIK BERGE, Knut, LAERDAHL, Jon K, LEREN, Trond P

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the epidermal growth factor homology domain repeat A of the low-density lipoprotein receptor…”
Get full text

Effect of mutations in the PCSK9 gene on the cell surface LDL receptors by Cameron, Jamie, Holla, Øystein L., Ranheim, Trine, Kulseth, Mari Ann, Berge, Knut Erik, Leren, Trond P.

“…The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is involved in the post-transcriptional regulation of the low-density lipoprotein (LDL)…”
Get full text

Identification of deletions and duplications in the low density lipoprotein receptor gene by MLPA by Holla, Øystein L., Teie, Christél, Berge, Knut Erik, Leren, Trond P.

“…Familial hypercholesterolemia (FH) is caused by mutations in the low density lipoprotein (LDL) receptor gene. In this study we have compared multiplex…”
Get full text