Search Results - "Holien, Toril"

Addiction to c-MYC in multiple myeloma by Holien, Toril, Våtsveen, Thea Kristin, Hella, Hanne, Waage, Anders, Sundan, Anders

“…In multiple myeloma, c-MYC is activated and contributes to the malignant phenotype. Targeting MYC by short hairpin RNA induced cell death in myeloma cell…”
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BMPR2 inhibits activin and BMP signaling via wild-type ALK2 by Olsen, Oddrun Elise, Sankar, Meenu, Elsaadi, Samah, Hella, Hanne, Buene, Glenn, Darvekar, Sagar Ramesh, Misund, Kristine, Katagiri, Takenobu, Knaus, Petra, Holien, Toril

“…TGF-β/BMP superfamily ligands require heteromeric complexes of type 1 and 2 receptors for ligand-dependent downstream signaling. Activin A, a TGF-β superfamily…”
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TGF-β contamination of purified recombinant GDF15 by Olsen, Oddrun Elise, Skjærvik, Anette, Størdal, Berit Fladvad, Sundan, Anders, Holien, Toril

“…Purified recombinant proteins for use in biomedical research are invaluable to investigate protein function. However, purity varies in protein batches made in…”
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The role of bone morphogenetic proteins in myeloma cell survival by Holien, Toril, Sundan, Anders

“…Abstract Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied…”
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Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors by Olsen, Oddrun Elise, Hella, Hanne, Elsaadi, Samah, Jacobi, Carsten, Martinez-Hackert, Erik, Holien, Toril

“…Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the…”
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Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B by Olsen, Oddrun Elise, Wader, Karin Fahl, Hella, Hanne, Mylin, Anne Kærsgaard, Turesson, Ingemar, Nesthus, Ingerid, Waage, Anders, Sundan, Anders, Holien, Toril

“…Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum…”
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Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Cutaneous T-Cell Lymphoma: A First-in-Human Phase I/II Study by Christensen, Eidi, Foss, Olav Andreas, Holien, Toril, Juzenas, Petras, Peng, Qian

“…Extracorporeal photopheresis (ECP) is a therapeutic modality used for T-cell-mediated disorders. This approach involves exposing isolated white blood cells to…”
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Monitoring multiple myeloma by quantification of recurrent mutations in serum by Rustad, Even Holth, Coward, Eivind, Skytøen, Emilie R, Misund, Kristine, Holien, Toril, Standal, Therese, Børset, Magne, Beisvag, Vidar, Myklebost, Ola, Meza-Zepeda, Leonardo A, Dai, Hong Yan, Sundan, Anders, Waage, Anders

“…Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple…”
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High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells by Andersson-Rusch, Clara, Liu, Bin, Quist-Løkken, Ingrid, Upton, Paul D., Olsen, Oddrun Elise, Hella, Hanne, Yang, Xudong, Tong, Zhen, Morrell, Nicholas W., Holien, Toril, Li, Wei

“…Endoglin (ENG) is a single-pass transmembrane protein highly expressed on vascular endothelial cells, although low expression levels can be detected in many…”
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GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients by Neckmann, Ulrike, Wolowczyk, Camilla, Hall, Martina, Almaas, Eivind, Ren, Jiang, Zhao, Sen, Johannessen, Bjarne, Skotheim, Rolf I, Bjørkøy, Geir, Ten Dijke, Peter, Holien, Toril

“…In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and…”
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Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells by Müller, Rebekka, Misund, Kristine, Holien, Toril, Bachke, Siri, Gilljam, Karin M, Våtsveen, Thea K, Rø, Torstein B, Bellacchio, Emanuele, Sundan, Anders, Otterlei, Marit

“…Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting…”
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Growth differentiation factor 15 (GDF15) promotes osteoclast differentiation and inhibits osteoblast differentiation and high serum GDF15 levels are associated with multiple myeloma bone disease by Westhrin, Marita, Moen, Siv Helen, Holien, Toril, Mylin, Anne Kærsgaard, Heickendorff, Lene, Olsen, Oddrun Elise, Sundan, Anders, Turesson, Ingemar, Gimsing, Peter, Waage, Anders, Standal, Therese

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Artesunate shows potent anti-tumor activity in B-cell lymphoma by Våtsveen, Thea Kristin, Myhre, Marit Renée, Steen, Chloé Beate, Wälchli, Sébastien, Lingjærde, Ole Christian, Bai, Baoyan, Dillard, Pierre, Theodossiou, Theodossis A, Holien, Toril, Sundan, Anders, Inderberg, Else Marit, Smeland, Erlend B, Myklebust, June Helen, Oksvold, Morten P

“…Although chemo-immunotherapy has led to an improved overall survival for most B-cell lymphoma types, relapsed and refractory disease remains a challenge. The…”
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Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 by Abdollahi, Pegah, Vandsemb, Esten N, Hjort, Magnus A, Misund, Kristine, Holien, Toril, Sponaas, Anne-Marit, Rø, Torstein B, Slørdahl, Tobias S, Børset, Magne

“…Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor…”
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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells by Quist-Løkken, Ingrid, Andersson-Rusch, Clara, Kastnes, Martin Haugrud, Kolos, Jürgen Markus, Jatzlau, Jerome, Hella, Hanne, Olsen, Oddrun Elise, Sundan, Anders, Knaus, Petra, Hausch, Felix, Holien, Toril

“…The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state…”
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Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B‐cell malignancies by Melvold, Katrine, Giliberto, Mariaserena, Karlsen, Linda, Ayuda‐Durán, Pilar, Hanes, Robert, Holien, Toril, Enserink, Jorrit, Brown, Jennifer R., Tjønnfjord, Geir E., Taskén, Kjetil, Skånland, Sigrid S.

“…Most patients with chronic lymphocytic leukemia (CLL) initially respond to targeted therapies, but eventually relapse and develop resistance. Novel treatment…”
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Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study by Christensen, Eidi, Foss, Olav A., Quist-Paulsen, Petter, Staur, Ingrid, Pettersen, Frode, Holien, Toril, Juzenas, Petras, Peng, Qian

“…Extracorporeal photopheresis (ECP), an immunomodulatory therapy for the treatment of chronic graft-versus-host disease (cGvHD), exposes isolated white blood…”
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Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines by Giliberto, Mariaserena, Santana, Leonardo Miranda, Holien, Toril, Misund, Kristine, Nakken, Sigve, Vodak, Daniel, Hovig, Eivind, Meza-Zepeda, Leonardo A, Coward, Eivind, Waage, Anders, Taskén, Kjetil, Skånland, Sigrid S

“…Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug…”
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Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate by Holien, Toril, Olsen, Oddrun E., Misund, Kristine, Hella, Hanne, Waage, Anders, Rø, Torstein B., Sundan, Anders

“…Objectives The use of new drugs has improved the treatment of multiple myeloma and diffuse large B‐cell lymphoma (DLBCL). Nevertheless, over time many patients…”
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Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells by Fagerli, Unn-Merete, Holt, Randi U., Holien, Toril, Vaatsveen, Thea K., Zhan, Fenghuang, Egeberg, Kjartan W., Barlogie, Bart, Waage, Anders, Aarset, Harald, Dai, Hong Yan, Shaughnessy, John D., Sundan, Anders, Børset, Magne

“…Multiple myeloma (MM) is characterized by accumulation and dissemination of malignant plasma cells (PCs) in the bone marrow (BM). Gene expression profiling of…”
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